Diversity-oriented synthesis around pyrrole cores .

One of the goals of synthetic Organic Chemistry in recent years is the development of new ways to explore chemical space in order to identify new biologically active entities and use them to uncover new therapeutic targets. The exploration of chemical space requires new synthetic processes, ideally...

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Detalhes bibliográficos
Autor: Leonardi, Marco
Tipo de documento: tese
Data de publicação:2019
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositório:Docta Complutense
Idioma:espanhol
OAI Identifier:oai:docta.ucm.es:20.500.14352/17165
Acesso em linha:https://hdl.handle.net/20.500.14352/17165
Access Level:Acceso aberto
Palavra-chave:615:54(043.2)
Química farmacéutica
Pharmaceutical chemistry
Química farmaceútica
2390 Química Farmacéutica
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spelling Diversity-oriented synthesis around pyrrole cores .Síntesis orientada a la diversidad basada en núcleos de PirrolLeonardi, Marco615:54(043.2)Química farmacéuticaPharmaceutical chemistryQuímica farmaceútica2390 Química FarmacéuticaOne of the goals of synthetic Organic Chemistry in recent years is the development of new ways to explore chemical space in order to identify new biologically active entities and use them to uncover new therapeutic targets. The exploration of chemical space requires new synthetic processes, ideally allowing the construction of several bonds in a single operation. In this connection, the MCR chemical space, defined as the ensemble of all possible molecules that can be obtained by multicomponent synthetic processes, is of particular interest. Diversity-Oriented Synthesis (DOS) is a recent approach to the identification of small bioactive molecules that is is designed to explore broader extensions of chemical space, its emphasis being on the generation of diverse scaffolds with varied molecular shapes. It is not directed at a specific biological target, and DOS libraries are used for the fast high-throughput identification of new ligands for varied targets in an effort to locate hit compounds in medicinal chemistry and chemical biology...Universidad Complutense de MadridVillacampa Sanz, MercedesMenéndez Ramos, José CarlosUniversidad Complutense de Madrid20192019-06-1820192019-06-18doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/17165reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Españolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/171652026-06-02T12:44:21Z
dc.title.none.fl_str_mv Diversity-oriented synthesis around pyrrole cores .
Síntesis orientada a la diversidad basada en núcleos de Pirrol
title Diversity-oriented synthesis around pyrrole cores .
spellingShingle Diversity-oriented synthesis around pyrrole cores .
Leonardi, Marco
615:54(043.2)
Química farmacéutica
Pharmaceutical chemistry
Química farmaceútica
2390 Química Farmacéutica
title_short Diversity-oriented synthesis around pyrrole cores .
title_full Diversity-oriented synthesis around pyrrole cores .
title_fullStr Diversity-oriented synthesis around pyrrole cores .
title_full_unstemmed Diversity-oriented synthesis around pyrrole cores .
title_sort Diversity-oriented synthesis around pyrrole cores .
dc.creator.none.fl_str_mv Leonardi, Marco
author Leonardi, Marco
author_facet Leonardi, Marco
author_role author
dc.contributor.none.fl_str_mv Villacampa Sanz, Mercedes
Menéndez Ramos, José Carlos
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615:54(043.2)
Química farmacéutica
Pharmaceutical chemistry
Química farmaceútica
2390 Química Farmacéutica
topic 615:54(043.2)
Química farmacéutica
Pharmaceutical chemistry
Química farmaceútica
2390 Química Farmacéutica
description One of the goals of synthetic Organic Chemistry in recent years is the development of new ways to explore chemical space in order to identify new biologically active entities and use them to uncover new therapeutic targets. The exploration of chemical space requires new synthetic processes, ideally allowing the construction of several bonds in a single operation. In this connection, the MCR chemical space, defined as the ensemble of all possible molecules that can be obtained by multicomponent synthetic processes, is of particular interest. Diversity-Oriented Synthesis (DOS) is a recent approach to the identification of small bioactive molecules that is is designed to explore broader extensions of chemical space, its emphasis being on the generation of diverse scaffolds with varied molecular shapes. It is not directed at a specific biological target, and DOS libraries are used for the fast high-throughput identification of new ligands for varied targets in an effort to locate hit compounds in medicinal chemistry and chemical biology...
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-06-18
2019
2019-06-18
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/17165
url https://hdl.handle.net/20.500.14352/17165
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301629

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