Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresis

Charged cyclodextrin (CD) derivatives were used as chiral selectors in electrokinetic chromatography (EKC) for the chiral separation of highlyhydrophobic neutral racemates such as atropisomeric polychlorinated biphenyls (PCBs). -CD-phosphated, -CD sulfated, succinylated--CD (Succ--CD) and succinylat...

Descripción completa

Detalles Bibliográficos
Autores: García Ruiz, Carmen|||0000-0001-5925-3449, Crego Navazo, Antonio Luis|||0000-0002-4083-5294, Marina Alegre, María Luisa|||0000-0002-5583-1624
Tipo de recurso: artículo
Fecha de publicación:2003
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/1353
Acceso en línea:http://hdl.handle.net/10017/1353
https://dx.doi.org/10.1002/elps.200305465
Access Level:acceso abierto
Palabra clave:Chiral capillary electrophoresis
Cyclodextrin derivatives
Polychlorinated biphenyls
Ciencia
Química analítica e industrial
Science
Chemistry, analytic and technical
id ES_8c9f197df1821b3faec3473caa0e1ddb
oai_identifier_str oai:ebuah.uah.es:10017/1353
network_acronym_str ES
network_name_str España
repository_id_str
spelling Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresisGarcía Ruiz, Carmen|||0000-0001-5925-3449Crego Navazo, Antonio Luis|||0000-0002-4083-5294Marina Alegre, María Luisa|||0000-0002-5583-1624Chiral capillary electrophoresisCyclodextrin derivativesPolychlorinated biphenylsCienciaQuímica analítica e industrialScienceChemistry, analytic and technicalCharged cyclodextrin (CD) derivatives were used as chiral selectors in electrokinetic chromatography (EKC) for the chiral separation of highlyhydrophobic neutral racemates such as atropisomeric polychlorinated biphenyls (PCBs). -CD-phosphated, -CD sulfated, succinylated--CD (Succ--CD) and succinylated- -CD (Succ- -CD) were used as anionic CDs. As cationic CD, 6-monodeoxy-6-monoamino- -CD ( -CD-NH2) was tested for the first time in order to separate PCBs. From the different CD derivatives employed, the best separations were obtained with the cationic CD derivative. Thus, the use of -CD-NH2 in phosphate buffer at pH 2.0 containing urea allowed the chiral recognition of eleven PCBs (45, 84, 88, 91, 95, 131, 136, 144, 149, 176, and 197). In this case, the addition of 2 M urea to the buffer solution was crucial to achieve the chiral separation of PCBs. The addition of acetonitrile to 10 mM phosphate buffer (pH 2.0) with 30 mM -CD-NH2 and 2 M urea improved considerably the chiral resolution obtained for PCBs 91, 95, 136, 144, 149, and 197 although an increase in the analysis time was also observed. All the results obtained were compared with those previously obtained with the dual CD system carboxymethyl--CD/ -CD. KJohn Wiley & Sons20032003-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/1353https://dx.doi.org/10.1002/elps.200305465reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengComunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/13532026-06-18T11:13:07Z
dc.title.none.fl_str_mv Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresis
title Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresis
spellingShingle Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresis
García Ruiz, Carmen|||0000-0001-5925-3449
Chiral capillary electrophoresis
Cyclodextrin derivatives
Polychlorinated biphenyls
Ciencia
Química analítica e industrial
Science
Chemistry, analytic and technical
title_short Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresis
title_full Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresis
title_fullStr Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresis
title_full_unstemmed Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresis
title_sort Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresis
dc.creator.none.fl_str_mv García Ruiz, Carmen|||0000-0001-5925-3449
Crego Navazo, Antonio Luis|||0000-0002-4083-5294
Marina Alegre, María Luisa|||0000-0002-5583-1624
author García Ruiz, Carmen|||0000-0001-5925-3449
author_facet García Ruiz, Carmen|||0000-0001-5925-3449
Crego Navazo, Antonio Luis|||0000-0002-4083-5294
Marina Alegre, María Luisa|||0000-0002-5583-1624
author_role author
author2 Crego Navazo, Antonio Luis|||0000-0002-4083-5294
Marina Alegre, María Luisa|||0000-0002-5583-1624
author2_role author
author
dc.subject.none.fl_str_mv Chiral capillary electrophoresis
Cyclodextrin derivatives
Polychlorinated biphenyls
Ciencia
Química analítica e industrial
Science
Chemistry, analytic and technical
topic Chiral capillary electrophoresis
Cyclodextrin derivatives
Polychlorinated biphenyls
Ciencia
Química analítica e industrial
Science
Chemistry, analytic and technical
description Charged cyclodextrin (CD) derivatives were used as chiral selectors in electrokinetic chromatography (EKC) for the chiral separation of highlyhydrophobic neutral racemates such as atropisomeric polychlorinated biphenyls (PCBs). -CD-phosphated, -CD sulfated, succinylated--CD (Succ--CD) and succinylated- -CD (Succ- -CD) were used as anionic CDs. As cationic CD, 6-monodeoxy-6-monoamino- -CD ( -CD-NH2) was tested for the first time in order to separate PCBs. From the different CD derivatives employed, the best separations were obtained with the cationic CD derivative. Thus, the use of -CD-NH2 in phosphate buffer at pH 2.0 containing urea allowed the chiral recognition of eleven PCBs (45, 84, 88, 91, 95, 131, 136, 144, 149, 176, and 197). In this case, the addition of 2 M urea to the buffer solution was crucial to achieve the chiral separation of PCBs. The addition of acetonitrile to 10 mM phosphate buffer (pH 2.0) with 30 mM -CD-NH2 and 2 M urea improved considerably the chiral resolution obtained for PCBs 91, 95, 136, 144, 149, and 197 although an increase in the analysis time was also observed. All the results obtained were compared with those previously obtained with the dual CD system carboxymethyl--CD/ -CD. K
publishDate 2003
dc.date.none.fl_str_mv 2003
2003-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/1353
https://dx.doi.org/10.1002/elps.200305465
url http://hdl.handle.net/10017/1353
https://dx.doi.org/10.1002/elps.200305465
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Comunidad de Madrid http://dx.doi.org/10.13039/100012818 Not available Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412947825000449
score 15.301629

Similares en LA Referencia