Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity

Salmón-Gómez, L. (Laura)|||/items/d2e59355-8dbe-4471-b3eb-be86678ef96c; Catalán-Goñi, V. (Victoria)|||/items/9a5a055c-323a-4b41-800f-65abf7f22c79; Ramirez-Sola, B. (Beatriz)|||/items/95970833-a061-4e49-b5d8-e6ecc6ec59c4; Aguas-Ayesa, M. (Maite)|||/items/2df52379-7f18-494d-aa9e-2f76f72356b8; Rodriguez, A. (Amaia)|||/items/50976a5f-9842-47f1-8a9c-508e59996427; Becerril-Mañas, S. (Sara)|||/items/5edb25ec-0edd-44eb-8ef1-c81d0ebd7300; Baixauli-Fons, J. (Jorge)|||/items/c863985d-f450-4807-a4fe-56d26f6e8dfa; Gutiérrez-Medina, S. (Sonsoles)|||/items/2cfa931d-4e41-4c98-9856-dc8b08a87419; Mugueta-Uriaque, M.C. (María del Carmen)|||/items/f3632e2b-2630-43b5-ab87-78066aba7b1b; Colina-Lorda, I. (Inmaculada)|||/items/20c3e784-a7bd-4dd8-8a50-6e2af683eb65; Perdomo-Zelaya, C.M. (Carolina María)|||/items/4197cb06-662e-44da-bef0-348099c09dcd; Silva-Frojan, C. (Camilo)|||/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef; Escalada, J. (Javier)|||/items/49a6b2d2-0f66-4005-b584-099f1728e80b; Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b; Gómez-Ambrosi, J. (Javier)|||/items/d287388d-bad7-4bc3-ab0a-b432782f5fbb

Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity

Growth differentiation factor 15 (GDF15) and fibroblast growth factor 21 (FGF21) are stress-induced cytokines increased in age-related and metabolic disorders. The aim of the present study was to analyze the association between circulating concentrations of GDF15 and FGF21 in obesity and type 2 diab...

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Authors:	Salmón-Gómez, L. (Laura)\|\|\|/items/d2e59355-8dbe-4471-b3eb-be86678ef96c, Catalán-Goñi, V. (Victoria)\|\|\|/items/9a5a055c-323a-4b41-800f-65abf7f22c79, Ramirez-Sola, B. (Beatriz)\|\|\|/items/95970833-a061-4e49-b5d8-e6ecc6ec59c4, Aguas-Ayesa, M. (Maite)\|\|\|/items/2df52379-7f18-494d-aa9e-2f76f72356b8, Rodriguez, A. (Amaia)\|\|\|/items/50976a5f-9842-47f1-8a9c-508e59996427, Becerril-Mañas, S. (Sara)\|\|\|/items/5edb25ec-0edd-44eb-8ef1-c81d0ebd7300, Baixauli-Fons, J. (Jorge)\|\|\|/items/c863985d-f450-4807-a4fe-56d26f6e8dfa, Gutiérrez-Medina, S. (Sonsoles)\|\|\|/items/2cfa931d-4e41-4c98-9856-dc8b08a87419, Mugueta-Uriaque, M.C. (María del Carmen)\|\|\|/items/f3632e2b-2630-43b5-ab87-78066aba7b1b, Colina-Lorda, I. (Inmaculada)\|\|\|/items/20c3e784-a7bd-4dd8-8a50-6e2af683eb65, Perdomo-Zelaya, C.M. (Carolina María)\|\|\|/items/4197cb06-662e-44da-bef0-348099c09dcd, Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef, Escalada, J. (Javier)\|\|\|/items/49a6b2d2-0f66-4005-b584-099f1728e80b, Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b, Gómez-Ambrosi, J. (Javier)\|\|\|/items/d287388d-bad7-4bc3-ab0a-b432782f5fbb
Format:	article
Publication Date:	2025
Country:	España
Institution:	Universidad de Navarra
Repository:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:	English
OAI Identifier:	oai:dadun.unav.edu:10171/122105
Online Access:	https://hdl.handle.net/10171/122105
Access Level:	Open access
Keyword:	GDF15 FGF21 Type 2 diabetes Obesity Aging FGF21/adiponectin ratio

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spelling	Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesitySalmón-Gómez, L. (Laura)\|\|\|/items/d2e59355-8dbe-4471-b3eb-be86678ef96cCatalán-Goñi, V. (Victoria)\|\|\|/items/9a5a055c-323a-4b41-800f-65abf7f22c79Ramirez-Sola, B. (Beatriz)\|\|\|/items/95970833-a061-4e49-b5d8-e6ecc6ec59c4Aguas-Ayesa, M. (Maite)\|\|\|/items/2df52379-7f18-494d-aa9e-2f76f72356b8Rodriguez, A. (Amaia)\|\|\|/items/50976a5f-9842-47f1-8a9c-508e59996427Becerril-Mañas, S. (Sara)\|\|\|/items/5edb25ec-0edd-44eb-8ef1-c81d0ebd7300Baixauli-Fons, J. (Jorge)\|\|\|/items/c863985d-f450-4807-a4fe-56d26f6e8dfaGutiérrez-Medina, S. (Sonsoles)\|\|\|/items/2cfa931d-4e41-4c98-9856-dc8b08a87419Mugueta-Uriaque, M.C. (María del Carmen)\|\|\|/items/f3632e2b-2630-43b5-ab87-78066aba7b1bColina-Lorda, I. (Inmaculada)\|\|\|/items/20c3e784-a7bd-4dd8-8a50-6e2af683eb65Perdomo-Zelaya, C.M. (Carolina María)\|\|\|/items/4197cb06-662e-44da-bef0-348099c09dcdSilva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465efEscalada, J. (Javier)\|\|\|/items/49a6b2d2-0f66-4005-b584-099f1728e80bFrühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663bGómez-Ambrosi, J. (Javier)\|\|\|/items/d287388d-bad7-4bc3-ab0a-b432782f5fbbGDF15FGF21Type 2 diabetesObesityAgingFGF21/adiponectin ratioGrowth differentiation factor 15 (GDF15) and fibroblast growth factor 21 (FGF21) are stress-induced cytokines increased in age-related and metabolic disorders. The aim of the present study was to analyze the association between circulating concentrations of GDF15 and FGF21 in obesity and type 2 diabetes (T2D) in the context of aging. Serum samples from 405 participants (33 with normal weight and normoglycemia (NG), 156 with obesity and NG, 157 with obesity and impaired glucose tolerance (IGT), and 59 with obesity and T2D) aged 47 ± 13 years, were recruited to study the serum GDF15 and FGF21 concentrations and their relationship with obesity, T2D, and aging. Adipokines (leptin and adiponectin) and other cardiometabolic risk factors were also measured. The circulating concentrations of GDF15 and FGF21 were significantly increased with obesity and further increased with IGT and T2D. Both GDF15 and FGF21 showed positive associations with glucose (r = 0.25, P < 0.001 and r = 0.40, P < 0.001, respectively) and insulin (r = 0.16, P < 0.01 and r = 0.27, P < 0.001, respectively) levels. Similarly, GDF15 and FGF21 were positively correlated with age (r = 0.55, P < 0.001 and r = 0.15, P < 0.01, respectively). Interestingly, the FGF21/adiponectin and GDF15/adiponectin ratios emerged as good biomarkers for the presence of T2D (AUC = 0.807 and 0.779, respectively). Our findings support that obesity, T2D, and aging increase the concentrations of both GDF15 and FGF21. Furthermore, GDF15 concentrations are more associated with aging while FGF21 levels are more related to the metabolic status. Finally, we propose the FGF21/adiponectin ratio as a novel biomarker for the detection of the presence of T2D.Springer NatureDadun. Depósito Académico Digital Universidad de Navarra20252025-01-0120252025-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/122105reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1221052026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity
title	Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity
spellingShingle	Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity Salmón-Gómez, L. (Laura)\|\|\|/items/d2e59355-8dbe-4471-b3eb-be86678ef96c GDF15 FGF21 Type 2 diabetes Obesity Aging FGF21/adiponectin ratio
title_short	Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity
title_full	Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity
title_fullStr	Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity
title_full_unstemmed	Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity
title_sort	Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity
dc.creator.none.fl_str_mv	Salmón-Gómez, L. (Laura)\|\|\|/items/d2e59355-8dbe-4471-b3eb-be86678ef96c Catalán-Goñi, V. (Victoria)\|\|\|/items/9a5a055c-323a-4b41-800f-65abf7f22c79 Ramirez-Sola, B. (Beatriz)\|\|\|/items/95970833-a061-4e49-b5d8-e6ecc6ec59c4 Aguas-Ayesa, M. (Maite)\|\|\|/items/2df52379-7f18-494d-aa9e-2f76f72356b8 Rodriguez, A. (Amaia)\|\|\|/items/50976a5f-9842-47f1-8a9c-508e59996427 Becerril-Mañas, S. (Sara)\|\|\|/items/5edb25ec-0edd-44eb-8ef1-c81d0ebd7300 Baixauli-Fons, J. (Jorge)\|\|\|/items/c863985d-f450-4807-a4fe-56d26f6e8dfa Gutiérrez-Medina, S. (Sonsoles)\|\|\|/items/2cfa931d-4e41-4c98-9856-dc8b08a87419 Mugueta-Uriaque, M.C. (María del Carmen)\|\|\|/items/f3632e2b-2630-43b5-ab87-78066aba7b1b Colina-Lorda, I. (Inmaculada)\|\|\|/items/20c3e784-a7bd-4dd8-8a50-6e2af683eb65 Perdomo-Zelaya, C.M. (Carolina María)\|\|\|/items/4197cb06-662e-44da-bef0-348099c09dcd Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef Escalada, J. (Javier)\|\|\|/items/49a6b2d2-0f66-4005-b584-099f1728e80b Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Gómez-Ambrosi, J. (Javier)\|\|\|/items/d287388d-bad7-4bc3-ab0a-b432782f5fbb
author	Salmón-Gómez, L. (Laura)\|\|\|/items/d2e59355-8dbe-4471-b3eb-be86678ef96c
author_facet	Salmón-Gómez, L. (Laura)\|\|\|/items/d2e59355-8dbe-4471-b3eb-be86678ef96c Catalán-Goñi, V. (Victoria)\|\|\|/items/9a5a055c-323a-4b41-800f-65abf7f22c79 Ramirez-Sola, B. (Beatriz)\|\|\|/items/95970833-a061-4e49-b5d8-e6ecc6ec59c4 Aguas-Ayesa, M. (Maite)\|\|\|/items/2df52379-7f18-494d-aa9e-2f76f72356b8 Rodriguez, A. (Amaia)\|\|\|/items/50976a5f-9842-47f1-8a9c-508e59996427 Becerril-Mañas, S. (Sara)\|\|\|/items/5edb25ec-0edd-44eb-8ef1-c81d0ebd7300 Baixauli-Fons, J. (Jorge)\|\|\|/items/c863985d-f450-4807-a4fe-56d26f6e8dfa Gutiérrez-Medina, S. (Sonsoles)\|\|\|/items/2cfa931d-4e41-4c98-9856-dc8b08a87419 Mugueta-Uriaque, M.C. (María del Carmen)\|\|\|/items/f3632e2b-2630-43b5-ab87-78066aba7b1b Colina-Lorda, I. (Inmaculada)\|\|\|/items/20c3e784-a7bd-4dd8-8a50-6e2af683eb65 Perdomo-Zelaya, C.M. (Carolina María)\|\|\|/items/4197cb06-662e-44da-bef0-348099c09dcd Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef Escalada, J. (Javier)\|\|\|/items/49a6b2d2-0f66-4005-b584-099f1728e80b Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Gómez-Ambrosi, J. (Javier)\|\|\|/items/d287388d-bad7-4bc3-ab0a-b432782f5fbb
author_role	author
author2	Catalán-Goñi, V. (Victoria)\|\|\|/items/9a5a055c-323a-4b41-800f-65abf7f22c79 Ramirez-Sola, B. (Beatriz)\|\|\|/items/95970833-a061-4e49-b5d8-e6ecc6ec59c4 Aguas-Ayesa, M. (Maite)\|\|\|/items/2df52379-7f18-494d-aa9e-2f76f72356b8 Rodriguez, A. (Amaia)\|\|\|/items/50976a5f-9842-47f1-8a9c-508e59996427 Becerril-Mañas, S. (Sara)\|\|\|/items/5edb25ec-0edd-44eb-8ef1-c81d0ebd7300 Baixauli-Fons, J. (Jorge)\|\|\|/items/c863985d-f450-4807-a4fe-56d26f6e8dfa Gutiérrez-Medina, S. (Sonsoles)\|\|\|/items/2cfa931d-4e41-4c98-9856-dc8b08a87419 Mugueta-Uriaque, M.C. (María del Carmen)\|\|\|/items/f3632e2b-2630-43b5-ab87-78066aba7b1b Colina-Lorda, I. (Inmaculada)\|\|\|/items/20c3e784-a7bd-4dd8-8a50-6e2af683eb65 Perdomo-Zelaya, C.M. (Carolina María)\|\|\|/items/4197cb06-662e-44da-bef0-348099c09dcd Silva-Frojan, C. (Camilo)\|\|\|/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef Escalada, J. (Javier)\|\|\|/items/49a6b2d2-0f66-4005-b584-099f1728e80b Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Gómez-Ambrosi, J. (Javier)\|\|\|/items/d287388d-bad7-4bc3-ab0a-b432782f5fbb
author2_role	author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	GDF15 FGF21 Type 2 diabetes Obesity Aging FGF21/adiponectin ratio
topic	GDF15 FGF21 Type 2 diabetes Obesity Aging FGF21/adiponectin ratio
description	Growth differentiation factor 15 (GDF15) and fibroblast growth factor 21 (FGF21) are stress-induced cytokines increased in age-related and metabolic disorders. The aim of the present study was to analyze the association between circulating concentrations of GDF15 and FGF21 in obesity and type 2 diabetes (T2D) in the context of aging. Serum samples from 405 participants (33 with normal weight and normoglycemia (NG), 156 with obesity and NG, 157 with obesity and impaired glucose tolerance (IGT), and 59 with obesity and T2D) aged 47 ± 13 years, were recruited to study the serum GDF15 and FGF21 concentrations and their relationship with obesity, T2D, and aging. Adipokines (leptin and adiponectin) and other cardiometabolic risk factors were also measured. The circulating concentrations of GDF15 and FGF21 were significantly increased with obesity and further increased with IGT and T2D. Both GDF15 and FGF21 showed positive associations with glucose (r = 0.25, P < 0.001 and r = 0.40, P < 0.001, respectively) and insulin (r = 0.16, P < 0.01 and r = 0.27, P < 0.001, respectively) levels. Similarly, GDF15 and FGF21 were positively correlated with age (r = 0.55, P < 0.001 and r = 0.15, P < 0.01, respectively). Interestingly, the FGF21/adiponectin and GDF15/adiponectin ratios emerged as good biomarkers for the presence of T2D (AUC = 0.807 and 0.779, respectively). Our findings support that obesity, T2D, and aging increase the concentrations of both GDF15 and FGF21. Furthermore, GDF15 concentrations are more associated with aging while FGF21 levels are more related to the metabolic status. Finally, we propose the FGF21/adiponectin ratio as a novel biomarker for the detection of the presence of T2D.
publishDate	2025
dc.date.none.fl_str_mv	2025 2025-01-01 2025 2025-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/122105
url	https://hdl.handle.net/10171/122105
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Springer Nature
publisher.none.fl_str_mv	Springer Nature
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity

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