Variation in allergen content in sublingual allergen immunotherapy with house dust mites
Includes supplementary materials for the online appendix.
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/59563 |
| Acceso en línea: | http://hdl.handle.net/10230/59563 http://dx.doi.org/10.1111/all.12694 |
| Access Level: | acceso abierto |
| Palabra clave: | Allergen content Efficacy Evidence-based medicine House dust mites’ sublingual allergen immunotherapy Weekly dosage |
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Variation in allergen content in sublingual allergen immunotherapy with house dust mitesMoreno Benítez, FranciscoEspinazo Romeu, MarisaLetrán Camacho, AntonioMas, SilviaGarcía-Cózar, Francisco J.Tabar, Ana IsabelAllergen contentEfficacyEvidence-based medicineHouse dust mites’ sublingual allergen immunotherapyWeekly dosageIncludes supplementary materials for the online appendix.Background. Allergen immunotherapy is a treatment modality which can be applied using different vaccines. The aim of this study was to quantify and compare the allergen content of different house dust mites (HDM)’ sublingual treatments and to review the evidence on their efficacy. Methods. Five sublingual allergen immunotherapy (SLIT) products were ordered and purchased at an ordinary pharmacy and masked for blinding before the study was started. Detection of Dermatophagoides pteronyssinus and Dermatophagoides farinae allergens Der p 1, Der f 1, Der p 2 and Der f 2 was carried out by immunoblotting and fluorescent multiplex. A literature search for meta-analyses and systematic reviews that included SLIT-HDM products was performed. Results. Der p 1 concentrations ranged from 0.6 to 14.5 μg/ml; similar figures were found for Der f 1 that ranged from 0.2 to 12.4 μg/ml. Der p 2+ Der f 2 ranged from 0.2 to 1.5 μg/ml. Data on efficacy are scarce for most of the five products. Conclusions. Substantial variations regarding allergen content were found among these five SLIT-HDM products. Therefore, it can be necessary to guarantee the quality of the SLIT-HDM products and to demonstrate their effectiveness before they are marketed. It seems necessary, for the moment, to take into account these characteristics of the products before prescribing.Wiley202420242015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/59563http://dx.doi.org/10.1111/all.12694reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAllergy. 2015 Oct 16;70(11):1413-20© 2015 The Authors. Allergy Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/595632026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Variation in allergen content in sublingual allergen immunotherapy with house dust mites |
| title |
Variation in allergen content in sublingual allergen immunotherapy with house dust mites |
| spellingShingle |
Variation in allergen content in sublingual allergen immunotherapy with house dust mites Moreno Benítez, Francisco Allergen content Efficacy Evidence-based medicine House dust mites’ sublingual allergen immunotherapy Weekly dosage |
| title_short |
Variation in allergen content in sublingual allergen immunotherapy with house dust mites |
| title_full |
Variation in allergen content in sublingual allergen immunotherapy with house dust mites |
| title_fullStr |
Variation in allergen content in sublingual allergen immunotherapy with house dust mites |
| title_full_unstemmed |
Variation in allergen content in sublingual allergen immunotherapy with house dust mites |
| title_sort |
Variation in allergen content in sublingual allergen immunotherapy with house dust mites |
| dc.creator.none.fl_str_mv |
Moreno Benítez, Francisco Espinazo Romeu, Marisa Letrán Camacho, Antonio Mas, Silvia García-Cózar, Francisco J. Tabar, Ana Isabel |
| author |
Moreno Benítez, Francisco |
| author_facet |
Moreno Benítez, Francisco Espinazo Romeu, Marisa Letrán Camacho, Antonio Mas, Silvia García-Cózar, Francisco J. Tabar, Ana Isabel |
| author_role |
author |
| author2 |
Espinazo Romeu, Marisa Letrán Camacho, Antonio Mas, Silvia García-Cózar, Francisco J. Tabar, Ana Isabel |
| author2_role |
author author author author author |
| dc.subject.none.fl_str_mv |
Allergen content Efficacy Evidence-based medicine House dust mites’ sublingual allergen immunotherapy Weekly dosage |
| topic |
Allergen content Efficacy Evidence-based medicine House dust mites’ sublingual allergen immunotherapy Weekly dosage |
| description |
Includes supplementary materials for the online appendix. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/59563 http://dx.doi.org/10.1111/all.12694 |
| url |
http://hdl.handle.net/10230/59563 http://dx.doi.org/10.1111/all.12694 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Allergy. 2015 Oct 16;70(11):1413-20 |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
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application/pdf application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley |
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Wiley |
| dc.source.none.fl_str_mv |
reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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15,198674 |