Insights into the fmnat active site of fad synthase: Aromaticity is essential for flavin binding and catalysis

16 pags., 9 figs., 3 tabs. -- This article belongs to the Special Issue Flavin Adenine Dinucleotide (FAD): Biosynthesis and Function

Detalhes bibliográficos
Autores: Serrano, Ana, Arilla-Luna, Sonia, Medina, Milagros
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/233588
Acesso em linha:http://hdl.handle.net/10261/233588
Access Level:acceso abierto
Palavra-chave:Flavin biosynthesis
Prokaryotic FAD synthase
Eukaryotic ATP:FMN:adenylyltransferase
Aromatic residues
Isoalloxazine
Binding
Rational mutagenesis
Isothermal titration calorimetry
Steady-state kinetics
Descrição
Resumo:16 pags., 9 figs., 3 tabs. -- This article belongs to the Special Issue Flavin Adenine Dinucleotide (FAD): Biosynthesis and Function