New strategies for the production of ready-to-implant bone scaffolds using supercritical fluid technology

This PhD Thesis highlights the advantages of the supercritical CO2 technology for the preparation of sterile scaffolds for regenerative medicine applications. On the one hand, this technology allows the production of polymeric scaffolds in the absence of organic solvents and downstream processes. In...

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Detalhes bibliográficos
Autor: Santos Rosales, Víctor
Formato: tesis doctoral
Fecha de publicación:2021
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/27145
Acesso em linha:http://hdl.handle.net/10347/27145
Access Level:acceso abierto
Palavra-chave:Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
Descrição
Resumo:This PhD Thesis highlights the advantages of the supercritical CO2 technology for the preparation of sterile scaffolds for regenerative medicine applications. On the one hand, this technology allows the production of polymeric scaffolds in the absence of organic solvents and downstream processes. In addition, the extraction capacity of supercritical CO2 also allows the preparation of bio-based aerogels. On the other hand, the antimicrobial effect of supercritical CO2 can be exploited for the sterilization of thermosensitive materials, including biodegradable scaffolds.