Acentrosomal microtubule assembly in mitosis: the where, when, and how

In mitosis the cell assembles the bipolar spindle, a microtubule (MT)-based apparatus that segregates the duplicated chromosomes into two daughter cells. Most animal cells enter mitosis with duplicated centrosomes that provide an active source of dynamic MTs. However, it is now established that spin...

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Detalhes bibliográficos
Autores: Meunier, Sylvain, Vernos, Isabelle, 1959-
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/33137
Acesso em linha:http://hdl.handle.net/10230/33137
http://dx.doi.org/10.1016/j.tcb.2015.09.001
Access Level:acceso abierto
Palavra-chave:Microtúbuls -- Metabolisme
Mitosi -- Fisiologia
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spelling Acentrosomal microtubule assembly in mitosis: the where, when, and howMeunier, SylvainVernos, Isabelle, 1959-Microtúbuls -- MetabolismeMitosi -- FisiologiaIn mitosis the cell assembles the bipolar spindle, a microtubule (MT)-based apparatus that segregates the duplicated chromosomes into two daughter cells. Most animal cells enter mitosis with duplicated centrosomes that provide an active source of dynamic MTs. However, it is now established that spindle assembly relies on the nucleation of acentrosomal MTs occurring around the chromosomes after nuclear envelope breakdown, and on pre-existing microtubules. Where chromosome-dependent MT nucleation occurs, when MT amplification takes place and how the two pathways function are still key questions that generate some controversies. We reconcile the data and present an integrated model accounting for acentrosomal microtubule assembly in the dividing cell.This work was supported by the Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013-2017’, SEV-2012-0208. Work in the laboratory of I.V. is supported by the Spanish Ministry of Economy and Competitiveness (grant BFU2012-37163)Elsevier201720172016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/33137http://dx.doi.org/10.1016/j.tcb.2015.09.001reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésTrends in Cell Biology. 2016 Feb;26(2):80-7info:eu-repo/grantAgreement/ES/3PN/BFU2012-37163© Elsevier http://dx.doi.org/10.1016/j.tcb.2015.09.001info:eu-repo/semantics/openAccessoai:recercat.cat:10230/331372026-05-29T05:05:01Z
dc.title.none.fl_str_mv Acentrosomal microtubule assembly in mitosis: the where, when, and how
title Acentrosomal microtubule assembly in mitosis: the where, when, and how
spellingShingle Acentrosomal microtubule assembly in mitosis: the where, when, and how
Meunier, Sylvain
Microtúbuls -- Metabolisme
Mitosi -- Fisiologia
title_short Acentrosomal microtubule assembly in mitosis: the where, when, and how
title_full Acentrosomal microtubule assembly in mitosis: the where, when, and how
title_fullStr Acentrosomal microtubule assembly in mitosis: the where, when, and how
title_full_unstemmed Acentrosomal microtubule assembly in mitosis: the where, when, and how
title_sort Acentrosomal microtubule assembly in mitosis: the where, when, and how
dc.creator.none.fl_str_mv Meunier, Sylvain
Vernos, Isabelle, 1959-
author Meunier, Sylvain
author_facet Meunier, Sylvain
Vernos, Isabelle, 1959-
author_role author
author2 Vernos, Isabelle, 1959-
author2_role author
dc.subject.none.fl_str_mv Microtúbuls -- Metabolisme
Mitosi -- Fisiologia
topic Microtúbuls -- Metabolisme
Mitosi -- Fisiologia
description In mitosis the cell assembles the bipolar spindle, a microtubule (MT)-based apparatus that segregates the duplicated chromosomes into two daughter cells. Most animal cells enter mitosis with duplicated centrosomes that provide an active source of dynamic MTs. However, it is now established that spindle assembly relies on the nucleation of acentrosomal MTs occurring around the chromosomes after nuclear envelope breakdown, and on pre-existing microtubules. Where chromosome-dependent MT nucleation occurs, when MT amplification takes place and how the two pathways function are still key questions that generate some controversies. We reconcile the data and present an integrated model accounting for acentrosomal microtubule assembly in the dividing cell.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/33137
http://dx.doi.org/10.1016/j.tcb.2015.09.001
url http://hdl.handle.net/10230/33137
http://dx.doi.org/10.1016/j.tcb.2015.09.001
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Trends in Cell Biology. 2016 Feb;26(2):80-7
info:eu-repo/grantAgreement/ES/3PN/BFU2012-37163
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.tcb.2015.09.001
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.tcb.2015.09.001
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,223283

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