Structural and Functional Brain Correlates of Cognitive Impairment in Euthymic Patients with Bipolar Disorder

Introduction Cognitive impairment in the euthymic phase is a well-established finding in bipolar disorder. However, its brain structural and/or functional correlates are uncertain. Methods Thirty-three euthymic bipolar patients with preserved memory and executive function and 28 euthymic bipolar pat...

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Autores: Alonso Lana, Silvia, Goikolea, José Manuel, Bonnín Roig, Caterina del Mar, Sarró, Salvador, Segura i Fàbregas, Bàrbara, Amann, Benedikt L., Monté Rubio, Gemma C., Moro, Noemí, Fernandez Corcuera, Paloma, Maristany, Teresa, Salvador, Raymond, Vieta i Pascual, Eduard, 1963-, Pomarol-Clotet, Edith, McKenna, Peter J.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2016
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/106487
Acesso em linha:https://hdl.handle.net/2445/106487
Access Level:Acceso aberto
Palavra-chave:Trastorn bipolar
Trastorns de la cognició
Psicologia cognitiva
Ressonància magnètica
Estudi de casos
Manic-depressive illness
Cognition disorders
Cognitive psychology
Magnetic resonance
Case studies
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spelling Structural and Functional Brain Correlates of Cognitive Impairment in Euthymic Patients with Bipolar DisorderAlonso Lana, SilviaGoikolea, José ManuelBonnín Roig, Caterina del MarSarró, SalvadorSegura i Fàbregas, BàrbaraAmann, Benedikt L.Monté Rubio, Gemma C.Moro, NoemíFernandez Corcuera, PalomaMaristany, TeresaSalvador, RaymondVieta i Pascual, Eduard, 1963-Pomarol-Clotet, EdithMcKenna, Peter J.Trastorn bipolarTrastorns de la cognicióPsicologia cognitivaRessonància magnèticaEstudi de casosManic-depressive illnessCognition disordersCognitive psychologyMagnetic resonanceCase studiesIntroduction Cognitive impairment in the euthymic phase is a well-established finding in bipolar disorder. However, its brain structural and/or functional correlates are uncertain. Methods Thirty-three euthymic bipolar patients with preserved memory and executive function and 28 euthymic bipolar patients with significant memory and/or executive impairment, as defined using two test batteries, the Rivermead Behavioural Memory Test (RBMT) and the Behavioural Assessment of the Dysexecutive Syndrome (BADS), plus 28 healthy controls underwent structural MRI using voxel-based morphometry (VBM). Twenty-seven of the cognitively preserved patients, 23 of the cognitively impaired patients and 28 controls also underwent fMRI during performance of the n-back working memory task. Results No clusters of grey or white matter volume difference were found between the two patient groups. During n-back performance, the cognitively impaired patients showed hypoactiva- tion compared to the cognitively preserved patients in a circumscribed region in the right dorsolateral prefrontal cortex. Both patient groups showed failure of de-activation in the medial frontal cortex compared to the healthy controls. Conclusions Cognitive impairment in euthymic bipolar patients appears from this study to be unrelated to structural brain abnormality, but there was some evidence for an association with altered prefrontal function.Public Library of Science (PLoS)2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/106487Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0158867PLoS One, 2016, vol. 11, num. 7, p. e0158867https://doi.org/10.1371/journal.pone.0158867cc-by (c) Alonso Lana, Silvia et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1064872026-05-27T06:46:51Z
dc.title.none.fl_str_mv Structural and Functional Brain Correlates of Cognitive Impairment in Euthymic Patients with Bipolar Disorder
title Structural and Functional Brain Correlates of Cognitive Impairment in Euthymic Patients with Bipolar Disorder
spellingShingle Structural and Functional Brain Correlates of Cognitive Impairment in Euthymic Patients with Bipolar Disorder
Alonso Lana, Silvia
Trastorn bipolar
Trastorns de la cognició
Psicologia cognitiva
Ressonància magnètica
Estudi de casos
Manic-depressive illness
Cognition disorders
Cognitive psychology
Magnetic resonance
Case studies
title_short Structural and Functional Brain Correlates of Cognitive Impairment in Euthymic Patients with Bipolar Disorder
title_full Structural and Functional Brain Correlates of Cognitive Impairment in Euthymic Patients with Bipolar Disorder
title_fullStr Structural and Functional Brain Correlates of Cognitive Impairment in Euthymic Patients with Bipolar Disorder
title_full_unstemmed Structural and Functional Brain Correlates of Cognitive Impairment in Euthymic Patients with Bipolar Disorder
title_sort Structural and Functional Brain Correlates of Cognitive Impairment in Euthymic Patients with Bipolar Disorder
dc.creator.none.fl_str_mv Alonso Lana, Silvia
Goikolea, José Manuel
Bonnín Roig, Caterina del Mar
Sarró, Salvador
Segura i Fàbregas, Bàrbara
Amann, Benedikt L.
Monté Rubio, Gemma C.
Moro, Noemí
Fernandez Corcuera, Paloma
Maristany, Teresa
Salvador, Raymond
Vieta i Pascual, Eduard, 1963-
Pomarol-Clotet, Edith
McKenna, Peter J.
author Alonso Lana, Silvia
author_facet Alonso Lana, Silvia
Goikolea, José Manuel
Bonnín Roig, Caterina del Mar
Sarró, Salvador
Segura i Fàbregas, Bàrbara
Amann, Benedikt L.
Monté Rubio, Gemma C.
Moro, Noemí
Fernandez Corcuera, Paloma
Maristany, Teresa
Salvador, Raymond
Vieta i Pascual, Eduard, 1963-
Pomarol-Clotet, Edith
McKenna, Peter J.
author_role author
author2 Goikolea, José Manuel
Bonnín Roig, Caterina del Mar
Sarró, Salvador
Segura i Fàbregas, Bàrbara
Amann, Benedikt L.
Monté Rubio, Gemma C.
Moro, Noemí
Fernandez Corcuera, Paloma
Maristany, Teresa
Salvador, Raymond
Vieta i Pascual, Eduard, 1963-
Pomarol-Clotet, Edith
McKenna, Peter J.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trastorn bipolar
Trastorns de la cognició
Psicologia cognitiva
Ressonància magnètica
Estudi de casos
Manic-depressive illness
Cognition disorders
Cognitive psychology
Magnetic resonance
Case studies
topic Trastorn bipolar
Trastorns de la cognició
Psicologia cognitiva
Ressonància magnètica
Estudi de casos
Manic-depressive illness
Cognition disorders
Cognitive psychology
Magnetic resonance
Case studies
description Introduction Cognitive impairment in the euthymic phase is a well-established finding in bipolar disorder. However, its brain structural and/or functional correlates are uncertain. Methods Thirty-three euthymic bipolar patients with preserved memory and executive function and 28 euthymic bipolar patients with significant memory and/or executive impairment, as defined using two test batteries, the Rivermead Behavioural Memory Test (RBMT) and the Behavioural Assessment of the Dysexecutive Syndrome (BADS), plus 28 healthy controls underwent structural MRI using voxel-based morphometry (VBM). Twenty-seven of the cognitively preserved patients, 23 of the cognitively impaired patients and 28 controls also underwent fMRI during performance of the n-back working memory task. Results No clusters of grey or white matter volume difference were found between the two patient groups. During n-back performance, the cognitively impaired patients showed hypoactiva- tion compared to the cognitively preserved patients in a circumscribed region in the right dorsolateral prefrontal cortex. Both patient groups showed failure of de-activation in the medial frontal cortex compared to the healthy controls. Conclusions Cognitive impairment in euthymic bipolar patients appears from this study to be unrelated to structural brain abnormality, but there was some evidence for an association with altered prefrontal function.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/106487
url https://hdl.handle.net/2445/106487
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0158867
PLoS One, 2016, vol. 11, num. 7, p. e0158867
https://doi.org/10.1371/journal.pone.0158867
dc.rights.none.fl_str_mv cc-by (c) Alonso Lana, Silvia et al., 2016
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Alonso Lana, Silvia et al., 2016
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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