Radiomics-Based Classification of Left Ventricular Non-compaction, Hypertrophic Cardiomyopathy, and Dilated Cardiomyopathy in Cardiovascular Magnetic Resonance

Miocardiopatía dilatada; Miocardiopatía hipertrófica; Radiómica

Detalhes bibliográficos
Autores: Izquierdo, Cristian, Casas Masnou, Guillem, Martin-Isla, Carlos, Campello, Victor M., Gkontra, Polyxeni, Guala, Andrea, Rodríguez Palomares, Jose Fernando
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/7507
Acesso em linha:https://hdl.handle.net/11351/7507
Access Level:acceso abierto
Palavra-chave:Sistema cardiovascular - Malalties - Imatgeria per ressonància magnètica
Sistema cardiovascular - Malalties - Diagnòstic
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging
DISEASES::Cardiovascular Diseases
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética
ENFERMEDADES::enfermedades cardiovasculares
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
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oai_identifier_str oai:scientiasalut.gencat.cat:11351/7507
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Radiomics-Based Classification of Left Ventricular Non-compaction, Hypertrophic Cardiomyopathy, and Dilated Cardiomyopathy in Cardiovascular Magnetic Resonance
title Radiomics-Based Classification of Left Ventricular Non-compaction, Hypertrophic Cardiomyopathy, and Dilated Cardiomyopathy in Cardiovascular Magnetic Resonance
spellingShingle Radiomics-Based Classification of Left Ventricular Non-compaction, Hypertrophic Cardiomyopathy, and Dilated Cardiomyopathy in Cardiovascular Magnetic Resonance
Izquierdo, Cristian
Sistema cardiovascular - Malalties - Imatgeria per ressonància magnètica
Sistema cardiovascular - Malalties - Diagnòstic
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging
DISEASES::Cardiovascular Diseases
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética
ENFERMEDADES::enfermedades cardiovasculares
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
title_short Radiomics-Based Classification of Left Ventricular Non-compaction, Hypertrophic Cardiomyopathy, and Dilated Cardiomyopathy in Cardiovascular Magnetic Resonance
title_full Radiomics-Based Classification of Left Ventricular Non-compaction, Hypertrophic Cardiomyopathy, and Dilated Cardiomyopathy in Cardiovascular Magnetic Resonance
title_fullStr Radiomics-Based Classification of Left Ventricular Non-compaction, Hypertrophic Cardiomyopathy, and Dilated Cardiomyopathy in Cardiovascular Magnetic Resonance
title_full_unstemmed Radiomics-Based Classification of Left Ventricular Non-compaction, Hypertrophic Cardiomyopathy, and Dilated Cardiomyopathy in Cardiovascular Magnetic Resonance
title_sort Radiomics-Based Classification of Left Ventricular Non-compaction, Hypertrophic Cardiomyopathy, and Dilated Cardiomyopathy in Cardiovascular Magnetic Resonance
dc.creator.none.fl_str_mv Izquierdo, Cristian
Casas Masnou, Guillem
Martin-Isla, Carlos
Campello, Victor M.
Gkontra, Polyxeni
Guala, Andrea
Rodríguez Palomares, Jose Fernando
author Izquierdo, Cristian
author_facet Izquierdo, Cristian
Casas Masnou, Guillem
Martin-Isla, Carlos
Campello, Victor M.
Gkontra, Polyxeni
Guala, Andrea
Rodríguez Palomares, Jose Fernando
author_role author
author2 Casas Masnou, Guillem
Martin-Isla, Carlos
Campello, Victor M.
Gkontra, Polyxeni
Guala, Andrea
Rodríguez Palomares, Jose Fernando
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Izquierdo C, Martin-Isla C, Campello VM, Gkontra P] Artificial Intelligence in Medicine Lab (BCN-AIM), Departament de Matemàtiques i Informàtica, Universitat de Barcelona, Barcelona, Spain. [Casas G, Rodríguez-Palomares JF] Servei de Cardiologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBER-CV, Instituto de Salud Carlos III, Madrid, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Guala A] Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBER-CV, Instituto de Salud Carlos III, Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Sistema cardiovascular - Malalties - Imatgeria per ressonància magnètica
Sistema cardiovascular - Malalties - Diagnòstic
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging
DISEASES::Cardiovascular Diseases
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética
ENFERMEDADES::enfermedades cardiovasculares
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
topic Sistema cardiovascular - Malalties - Imatgeria per ressonància magnètica
Sistema cardiovascular - Malalties - Diagnòstic
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging
DISEASES::Cardiovascular Diseases
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética
ENFERMEDADES::enfermedades cardiovasculares
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
description Miocardiopatía dilatada; Miocardiopatía hipertrófica; Radiómica
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7507
url https://hdl.handle.net/11351/7507
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Cardiovascular Medicine;8
https://doi.org/10.3389/fcvm.2021.764312
info:eu-repo/grantAgreement/EC/H2020/825903
info:eu-repo/grantAgreement/ES/PE2017-2020/IJC2018-037349-I
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411949871104000
spelling Radiomics-Based Classification of Left Ventricular Non-compaction, Hypertrophic Cardiomyopathy, and Dilated Cardiomyopathy in Cardiovascular Magnetic ResonanceIzquierdo, CristianCasas Masnou, GuillemMartin-Isla, CarlosCampello, Victor M.Gkontra, PolyxeniGuala, AndreaRodríguez Palomares, Jose FernandoSistema cardiovascular - Malalties - Imatgeria per ressonància magnèticaSistema cardiovascular - Malalties - DiagnòsticANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance ImagingDISEASES::Cardiovascular DiseasesOther subheadings::Other subheadings::Other subheadings::/diagnostic imagingTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnéticaENFERMEDADES::enfermedades cardiovascularesOtros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagenMiocardiopatía dilatada; Miocardiopatía hipertrófica; RadiómicaDilated cardiomyopathy; Hypertrophic cardiomyopathy; RadiomicsMiocardiopatia dilatada; Miocardiopatia hipertròfica; RadiòmicaLeft Ventricular (LV) Non-compaction (LVNC), Hypertrophic Cardiomyopathy (HCM), and Dilated Cardiomyopathy (DCM) share morphological and functional traits that increase the diagnosis complexity. Additional clinical information, besides imaging data such as cardiovascular magnetic resonance (CMR), is usually required to reach a definitive diagnosis, including electrocardiography (ECG), family history, and genetics. Alternatively, indices of hypertrabeculation have been introduced, but they require tedious and time-consuming delineations of the trabeculae on the CMR images. In this paper, we propose a radiomics approach to automatically encode differences in the underlying shape, gray-scale and textural information in the myocardium and its trabeculae, which may enhance the capacity to differentiate between these overlapping conditions. A total of 118 subjects, including 35 patients with LVNC, 25 with HCM, 37 with DCM, as well as 21 healthy volunteers (NOR), underwent CMR imaging. A comprehensive radiomics characterization was applied to LV short-axis images to quantify shape, first-order, co-occurrence matrix, run-length matrix, and local binary patterns. Conventional CMR indices (LV volumes, mass, wall thickness, LV ejection fraction—LVEF—), as well as hypertrabeculation indices by Petersen and Jacquier, were also analyzed. State-of-the-art Machine Learning (ML) models (one-vs.-rest Support Vector Machine—SVM—, Logistic Regression—LR—, and Random Forest Classifier—RF—) were used for one-vs.-rest classification tasks. The use of radiomics models for the automated diagnosis of LVNC, HCM, and DCM resulted in excellent one-vs.-rest ROC-AUC values of 0.95 while generating these results without the need for the delineation of the trabeculae. First-order and texture features resulted to be among the most discriminative features in the obtained radiomics signatures, indicating their added value for quantifying relevant tissue patterns in cardiomyopathy differential diagnosis.This publication was partially funded by the European Union's Horizon 2020 research and innovation euCanSHare project under grant agreement No 825903. KL received funding from the Spanish Ministry of Science, Innovation and Universities under grant agreement RTI2018-099898-B-I00. AG has received funding from the Spanish Ministry of Science, Innovation and Universities (IJC2018-037349-I).Frontiers MediaInstitut Català de la Salut[Izquierdo C, Martin-Isla C, Campello VM, Gkontra P] Artificial Intelligence in Medicine Lab (BCN-AIM), Departament de Matemàtiques i Informàtica, Universitat de Barcelona, Barcelona, Spain. [Casas G, Rodríguez-Palomares JF] Servei de Cardiologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBER-CV, Instituto de Salud Carlos III, Madrid, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Guala A] Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBER-CV, Instituto de Salud Carlos III, Madrid, SpainVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/7507Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésFrontiers in Cardiovascular Medicine;8https://doi.org/10.3389/fcvm.2021.764312info:eu-repo/grantAgreement/EC/H2020/825903info:eu-repo/grantAgreement/ES/PE2017-2020/IJC2018-037349-IAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/75072026-06-12T09:38:37Z
score 15,812455

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