Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug–naïve first-episode psychosis

Circulating white blood cells (leucocytes), which form the peripheral immune system, are crucial in inflammatory processes but their role in brain structural change in schizophrenia has been scarcely studied. With this study we want to determine how and which type of white blood cells are associated...

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Autores: Toll, Alba, Blanco Hinojo, Laura, 1981-, Berge Baquero, Daniel, Martín-Subero, Marta, Casanovas, Francesc, El-Abidi, Khadija, Pérez Solà, Víctor, Mané Santacana, Anna
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/57898
Acesso em linha:http://hdl.handle.net/10230/57898
http://dx.doi.org/10.1016/j.euroneuro.2023.01.002
Access Level:Acceso aberto
Palavra-chave:Deepres- sive symptoms
First-episode psychosis
Hippocampus
Lymphocyte
Schizophrenia
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spelling Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug–naïve first-episode psychosisToll, AlbaBlanco Hinojo, Laura, 1981-Berge Baquero, DanielMartín-Subero, MartaCasanovas, FrancescEl-Abidi, KhadijaPérez Solà, VíctorMané Santacana, AnnaDeepres- sive symptomsFirst-episode psychosisHippocampusLymphocyteSchizophreniaCirculating white blood cells (leucocytes), which form the peripheral immune system, are crucial in inflammatory processes but their role in brain structural change in schizophrenia has been scarcely studied. With this study we want to determine how and which type of white blood cells are associated with hippocampal volume (as a key structure in schi- zophrenia etiopathology) in first episode psychosis (FEP) patients. Moreover, to determine the association between white blood cells and clinical symptomatology, including positive and negative symptoms, cognition and depression. For this purpose fifty drug-naïve FEP were included in this study. All patients underwent an assessment at baseline and at 1 year follow-up, including sociodemographic and clinical variables (substance use, DUP, PANSS, GAF and CDSS). Fasting blood samples were obtained before administering any medication at baseline. Structural T1 MRI was performed at baseline and brain volumes were quantified. In the present study, higher lymphocyte count was associated with larger right hippocampal volume at baseline in FEP drug-naive patients. Higher lymphocyte count was associated with lower depressive symptomatology measured with CDSS and Marder depressive factor from PANSS at baseline and 1-year follow -up. These results suggest that lymphocytes may have a protective effect in hippocampal volume at baseli- ne in antipsychotic naïve FEP and also, are associated with a better depressive course over follow up. These results open the door to identify new biomarkers and therapeutic targets for patients with schizophrenia.Elsevier202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/57898http://dx.doi.org/10.1016/j.euroneuro.2023.01.002reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEur Neuropsychopharmacol. 2023;69:47-55© 2023 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/578982026-05-29T05:05:01Z
dc.title.none.fl_str_mv Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug–naïve first-episode psychosis
title Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug–naïve first-episode psychosis
spellingShingle Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug–naïve first-episode psychosis
Toll, Alba
Deepres- sive symptoms
First-episode psychosis
Hippocampus
Lymphocyte
Schizophrenia
title_short Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug–naïve first-episode psychosis
title_full Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug–naïve first-episode psychosis
title_fullStr Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug–naïve first-episode psychosis
title_full_unstemmed Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug–naïve first-episode psychosis
title_sort Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug–naïve first-episode psychosis
dc.creator.none.fl_str_mv Toll, Alba
Blanco Hinojo, Laura, 1981-
Berge Baquero, Daniel
Martín-Subero, Marta
Casanovas, Francesc
El-Abidi, Khadija
Pérez Solà, Víctor
Mané Santacana, Anna
author Toll, Alba
author_facet Toll, Alba
Blanco Hinojo, Laura, 1981-
Berge Baquero, Daniel
Martín-Subero, Marta
Casanovas, Francesc
El-Abidi, Khadija
Pérez Solà, Víctor
Mané Santacana, Anna
author_role author
author2 Blanco Hinojo, Laura, 1981-
Berge Baquero, Daniel
Martín-Subero, Marta
Casanovas, Francesc
El-Abidi, Khadija
Pérez Solà, Víctor
Mané Santacana, Anna
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Deepres- sive symptoms
First-episode psychosis
Hippocampus
Lymphocyte
Schizophrenia
topic Deepres- sive symptoms
First-episode psychosis
Hippocampus
Lymphocyte
Schizophrenia
description Circulating white blood cells (leucocytes), which form the peripheral immune system, are crucial in inflammatory processes but their role in brain structural change in schizophrenia has been scarcely studied. With this study we want to determine how and which type of white blood cells are associated with hippocampal volume (as a key structure in schi- zophrenia etiopathology) in first episode psychosis (FEP) patients. Moreover, to determine the association between white blood cells and clinical symptomatology, including positive and negative symptoms, cognition and depression. For this purpose fifty drug-naïve FEP were included in this study. All patients underwent an assessment at baseline and at 1 year follow-up, including sociodemographic and clinical variables (substance use, DUP, PANSS, GAF and CDSS). Fasting blood samples were obtained before administering any medication at baseline. Structural T1 MRI was performed at baseline and brain volumes were quantified. In the present study, higher lymphocyte count was associated with larger right hippocampal volume at baseline in FEP drug-naive patients. Higher lymphocyte count was associated with lower depressive symptomatology measured with CDSS and Marder depressive factor from PANSS at baseline and 1-year follow -up. These results suggest that lymphocytes may have a protective effect in hippocampal volume at baseli- ne in antipsychotic naïve FEP and also, are associated with a better depressive course over follow up. These results open the door to identify new biomarkers and therapeutic targets for patients with schizophrenia.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/57898
http://dx.doi.org/10.1016/j.euroneuro.2023.01.002
url http://hdl.handle.net/10230/57898
http://dx.doi.org/10.1016/j.euroneuro.2023.01.002
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Eur Neuropsychopharmacol. 2023;69:47-55
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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