Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases

This review focuses on the role of small extracellular vesicles in the pathophysiological mechanisms of retinal degenerative diseases. Many of these mechanisms are related to or modulated by the oxidative burden of retinal cells. It has been recently demonstrated that cellular communication in the r...

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Detalhes bibliográficos
Autores: Romero Gómez, Francisco Javier, Díaz Llopis, Manuel, Romero Gómez, María Inmaculada, Miranda, María, Romero Wenz, Rebeca, Sancho Pellúz, Javier, Romero, Belén, Muriach, María, Barcia, Jorge Miguel
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/12667
Acesso em linha:http://hdl.handle.net/11268/12667
Access Level:acceso abierto
Palavra-chave:Bioquímica
Fisopatología
Exosomas
Biología molecular
Goal 3: Ensure healthy lives and promote well-being for all at all ages
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spelling Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative DiseasesRomero Gómez, Francisco JavierDíaz Llopis, ManuelRomero Gómez, María InmaculadaMiranda, MaríaRomero Wenz, RebecaSancho Pellúz, JavierRomero, BelénMuriach, MaríaBarcia, Jorge MiguelBioquímicaFisopatologíaExosomasBioquímicaBiología molecularGoal 3: Ensure healthy lives and promote well-being for all at all agesThis review focuses on the role of small extracellular vesicles in the pathophysiological mechanisms of retinal degenerative diseases. Many of these mechanisms are related to or modulated by the oxidative burden of retinal cells. It has been recently demonstrated that cellular communication in the retina involves extracellular vesicles and that their rate of release and cargo features might be affected by the cellular environment, and in some instances, they might also be mediated by autophagy. The fate of these vesicles is diverse: they could end up in circulation being used as markers, or target neighbor cells modulating gene and protein expression, or eventually, in angiogenesis. Neovascularization in the retina promotes vision loss in diseases such as diabetic retinopathy and age-related macular degeneration. The importance of micro RNAs, either as small extracellular vesicles’ cargo or free circulating, in the regulation of retinal angiogenesis is also discussed.20242024-02-0720242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/12667reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/126672026-06-11T12:41:27Z
dc.title.none.fl_str_mv Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases
title Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases
spellingShingle Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases
Romero Gómez, Francisco Javier
Bioquímica
Fisopatología
Exosomas
Bioquímica
Biología molecular
Goal 3: Ensure healthy lives and promote well-being for all at all ages
title_short Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases
title_full Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases
title_fullStr Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases
title_full_unstemmed Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases
title_sort Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases
dc.creator.none.fl_str_mv Romero Gómez, Francisco Javier
Díaz Llopis, Manuel
Romero Gómez, María Inmaculada
Miranda, María
Romero Wenz, Rebeca
Sancho Pellúz, Javier
Romero, Belén
Muriach, María
Barcia, Jorge Miguel
author Romero Gómez, Francisco Javier
author_facet Romero Gómez, Francisco Javier
Díaz Llopis, Manuel
Romero Gómez, María Inmaculada
Miranda, María
Romero Wenz, Rebeca
Sancho Pellúz, Javier
Romero, Belén
Muriach, María
Barcia, Jorge Miguel
author_role author
author2 Díaz Llopis, Manuel
Romero Gómez, María Inmaculada
Miranda, María
Romero Wenz, Rebeca
Sancho Pellúz, Javier
Romero, Belén
Muriach, María
Barcia, Jorge Miguel
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Bioquímica
Fisopatología
Exosomas
Bioquímica
Biología molecular
Goal 3: Ensure healthy lives and promote well-being for all at all ages
topic Bioquímica
Fisopatología
Exosomas
Bioquímica
Biología molecular
Goal 3: Ensure healthy lives and promote well-being for all at all ages
description This review focuses on the role of small extracellular vesicles in the pathophysiological mechanisms of retinal degenerative diseases. Many of these mechanisms are related to or modulated by the oxidative burden of retinal cells. It has been recently demonstrated that cellular communication in the retina involves extracellular vesicles and that their rate of release and cargo features might be affected by the cellular environment, and in some instances, they might also be mediated by autophagy. The fate of these vesicles is diverse: they could end up in circulation being used as markers, or target neighbor cells modulating gene and protein expression, or eventually, in angiogenesis. Neovascularization in the retina promotes vision loss in diseases such as diabetic retinopathy and age-related macular degeneration. The importance of micro RNAs, either as small extracellular vesicles’ cargo or free circulating, in the regulation of retinal angiogenesis is also discussed.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-02-07
2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/12667
url http://hdl.handle.net/11268/12667
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.228081

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