Nanosystems for ophthalmic drug delivery in the treatment of chronic and inflammatory pathologies
Chronic ocular diseases that involve inflammatory conditions affects both the anterior and posterior segments of the eye, which in many cases lack of effective and well tolerated treatments at the same time. These types of pathologies can be subdivided into two welldifferentiated groups: those induc...
| Autor: | |
|---|---|
| Tipo de documento: | tese |
| Data de publicação: | 2023 |
| País: | España |
| Recursos: | Universidad Complutense de Madrid (UCM) |
| Repositório: | Docta Complutense |
| Idioma: | inglês |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/4180 |
| Acesso em linha: | https://hdl.handle.net/20.500.14352/4180 |
| Access Level: | Acceso aberto |
| Palavra-chave: | 617.7(043.2) Eyes diseases Ojos enfermedades Oftalmología 3201.09 Oftalmología |
| Resumo: | Chronic ocular diseases that involve inflammatory conditions affects both the anterior and posterior segments of the eye, which in many cases lack of effective and well tolerated treatments at the same time. These types of pathologies can be subdivided into two welldifferentiated groups: those induced by inflammatory processes that end up developing a vicious cycle, such as uveitis or conjunctivitis, and those generated by pathophysiological transformations, or modifications that evolve towards inflammatory and degenerative processes. This last instance would be the case of prevalent pathologies such as dry eye disease (DED) and glaucoma. In DED, changes on the ocular surface occur such as tear evaporation, change in the lipid or aqueous profile of the precorneal tear film among others. Meanwhile, in glaucoma a damage in the nervous fibers of the retina is produced associated in most cases to an IOP increment. In both cases a chronic inflammation is induced giving rise rise to chronic and degenerative processes of both the anterior segment (fibrosis, abrasion, corneal ulcerations, and vision loss) and the posterior segment of the eye (neuroinflammation, excitotoxicity and retinal neurodegeneration). In fact, there is growing evidence about the relation between neurodegenerative diaseases and inflammatory events... |
|---|