Inversions and genomic differentiation after secondary contact: when drift contributes to maintenance, not loss, of differentiation

Due to their effects on reducing recombination, chromosomal inversions may play an important role in speciation by establishing and/or maintaining linked blocks of genes causing reproductive isolation (RI) between populations. This view fits empirical data indicating that inversions typically harbor...

Descripción completa

Detalles Bibliográficos
Autores: Rafajlović, Marina, Rambla de Argila, Jordi, Feder, Jeffrey L., Navarro i Cuartiellas, Arcadi, 1969-, Faria, Rui
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/48025
Acceso en línea:http://hdl.handle.net/10230/48025
http://dx.doi.org/10.1111/evo.14223
Access Level:acceso abierto
Palabra clave:Genètica
Flux gènic
Genètica de poblacions
id ES_7db72c3e2b5aa6f708efe6aaa573a893
oai_identifier_str oai:recercat.cat:10230/48025
network_acronym_str ES
network_name_str España
repository_id_str
spelling Inversions and genomic differentiation after secondary contact: when drift contributes to maintenance, not loss, of differentiationRafajlović, MarinaRambla de Argila, JordiFeder, Jeffrey L.Navarro i Cuartiellas, Arcadi, 1969-Faria, RuiGenèticaFlux gènicGenètica de poblacionsDue to their effects on reducing recombination, chromosomal inversions may play an important role in speciation by establishing and/or maintaining linked blocks of genes causing reproductive isolation (RI) between populations. This view fits empirical data indicating that inversions typically harbor loci involved in RI. However, previous computer simulations of infinite populations with two to four loci involved in RI implied that, even with gene flux as low as 10-8 per gamete, per generation between alternative arrangements, inversions may not have large, qualitative advantages over collinear regions in maintaining population differentiation after secondary contact. Here, we report that finite population sizes can help counteract the homogenizing consequences of gene flux, especially when several fitness-related loci reside within the inversion. In these cases, the persistence time of differentiation after secondary contact can be similar to when gene flux is absent and notably longer than the persistence time without inversions. Thus, despite gene flux, population differentiation may be maintained for up to 100,000 generations, during which time new incompatibilities and/or local adaptations might accumulate and facilitate progress toward speciation. How often these conditions are met in nature remains to be determined.This study was supported by the European Regional Development Fund (FCOMP-01-0124-FEDER-014272), FCT – Foundation for Science and Technology (PTDC/BIA-EVF/113805/2009), Ministerio de Ciencia e Innovación, Spain (PGC2018-101927-B-I00, MINECO/FEDER, UE), by the Spanish National Institute of Bioinformatics (PT17/0009/0020), and by “Unidad de Excelencia María de Maeztu,” funded by the MINECO (ref: MDM-2014-0370). MR was funded by the Hasselblad Foundation (Grant for Female Scientists), European Research Council and the Swedish Research Councils VR and Formas (Linnaeus grant to the Centre for Marine Evolutionary Biology), and by an additional grant from Formas (to MR; grant number 2019-00882). JLF was funded by support from the National Science Foundation and United States Department of Agriculture NIFA program. RF was funded by FCT (SFRH/BPD/89313/2012) and by the European Union's Horizon 2020 research and innovation program, under the Marie Sklodowska-Curie grant agreement number 706376; and is currently funded by FEDER through the Operational Competitiveness Factors Program COMPETE and by National Funds through the FCT project “Hybrabbid” (PTDC/BIA-EVL/30628/2017 and POCI-01-0145-FEDER-030628). The simulations were performed on resources at Chalmers Centre for Computational Science and Engineering (C3SE), and at National Supercomputer Centre at Linköping University (NSC) provided by the Swedish National Infrastructure for Computing (SNIC), partially funded by the Swedish Research Council through grant agreement no. 2018–05973Wiley202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/48025http://dx.doi.org/10.1111/evo.14223reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/EC/H2020/706376© 2021 Marina Rafajlovic et al. Evolution published by Wiley Periodicals LLC on behalf of The Society for the Study of Evolution. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposeshttps://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/480252026-05-29T05:05:01Z
dc.title.none.fl_str_mv Inversions and genomic differentiation after secondary contact: when drift contributes to maintenance, not loss, of differentiation
title Inversions and genomic differentiation after secondary contact: when drift contributes to maintenance, not loss, of differentiation
spellingShingle Inversions and genomic differentiation after secondary contact: when drift contributes to maintenance, not loss, of differentiation
Rafajlović, Marina
Genètica
Flux gènic
Genètica de poblacions
title_short Inversions and genomic differentiation after secondary contact: when drift contributes to maintenance, not loss, of differentiation
title_full Inversions and genomic differentiation after secondary contact: when drift contributes to maintenance, not loss, of differentiation
title_fullStr Inversions and genomic differentiation after secondary contact: when drift contributes to maintenance, not loss, of differentiation
title_full_unstemmed Inversions and genomic differentiation after secondary contact: when drift contributes to maintenance, not loss, of differentiation
title_sort Inversions and genomic differentiation after secondary contact: when drift contributes to maintenance, not loss, of differentiation
dc.creator.none.fl_str_mv Rafajlović, Marina
Rambla de Argila, Jordi
Feder, Jeffrey L.
Navarro i Cuartiellas, Arcadi, 1969-
Faria, Rui
author Rafajlović, Marina
author_facet Rafajlović, Marina
Rambla de Argila, Jordi
Feder, Jeffrey L.
Navarro i Cuartiellas, Arcadi, 1969-
Faria, Rui
author_role author
author2 Rambla de Argila, Jordi
Feder, Jeffrey L.
Navarro i Cuartiellas, Arcadi, 1969-
Faria, Rui
author2_role author
author
author
author
dc.subject.none.fl_str_mv Genètica
Flux gènic
Genètica de poblacions
topic Genètica
Flux gènic
Genètica de poblacions
description Due to their effects on reducing recombination, chromosomal inversions may play an important role in speciation by establishing and/or maintaining linked blocks of genes causing reproductive isolation (RI) between populations. This view fits empirical data indicating that inversions typically harbor loci involved in RI. However, previous computer simulations of infinite populations with two to four loci involved in RI implied that, even with gene flux as low as 10-8 per gamete, per generation between alternative arrangements, inversions may not have large, qualitative advantages over collinear regions in maintaining population differentiation after secondary contact. Here, we report that finite population sizes can help counteract the homogenizing consequences of gene flux, especially when several fitness-related loci reside within the inversion. In these cases, the persistence time of differentiation after secondary contact can be similar to when gene flux is absent and notably longer than the persistence time without inversions. Thus, despite gene flux, population differentiation may be maintained for up to 100,000 generations, during which time new incompatibilities and/or local adaptations might accumulate and facilitate progress toward speciation. How often these conditions are met in nature remains to be determined.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/48025
http://dx.doi.org/10.1111/evo.14223
url http://hdl.handle.net/10230/48025
http://dx.doi.org/10.1111/evo.14223
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/EC/H2020/706376
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411684180819968
score 15,228081

Similares en LA Referencia