Host-directed antivirals A realistic alternative to fight Zika virus

Zika virus (ZIKV), a mosquito-borne flavivirus, was an almost neglected pathogen until its introduction in the Americas in 2015, where it has been responsible for a threat to global health, causing a great social and sanitary alarm due to its increased virulence, rapid spread, and an association wit...

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Detalles Bibliográficos
Autores: Saiz Calahorra, Juan Carlos, Jiménez de Oya, Nereida, Blázquez, Ana B., Escribano-Romero, Estela, Martín-Acebes, M. A.
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/291200
Acceso en línea:http://hdl.handle.net/10261/291200
Access Level:acceso abierto
Palabra clave:Flavivirus
Zika virus
Therapy
Host-directed antivirals
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spelling Host-directed antivirals A realistic alternative to fight Zika virusSaiz Calahorra, Juan CarlosJiménez de Oya, NereidaBlázquez, Ana B.Escribano-Romero, EstelaMartín-Acebes, M. A.FlavivirusZika virusTherapyHost-directed antiviralsZika virus (ZIKV), a mosquito-borne flavivirus, was an almost neglected pathogen until its introduction in the Americas in 2015, where it has been responsible for a threat to global health, causing a great social and sanitary alarm due to its increased virulence, rapid spread, and an association with severe neurological and ophthalmological complications. Currently, no specific antiviral therapy against ZIKV is available, and treatments are palliative and mainly directed toward the relief of symptoms, such as fever and rash, by administering antipyretics, anti-histamines, and fluids for dehydration. Nevertheless, lately, search for antivirals has been a major aim in ZIKV investigations. To do so, screening of libraries from different sources, testing of natural compounds, and repurposing of drugs with known antiviral activity have allowed the identification of several antiviral candidates directed to both viral (structural proteins and enzymes) and cellular elements. Here, we present an updated review of current knowledge about anti-ZIKV strategies, focusing on host-directed antivirals as a realistic alternative to combat ZIKV infection.Peer reviewedMultidisciplinary Digital Publishing InstituteEscribano-Romero, Estela [0000-0002-5036-7607]Jiménez de Oya, Nereida [0000-0003-3129-813X]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/291200reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésDepartamento de BiotecnologíaSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2912002026-05-22T06:33:51Z
dc.title.none.fl_str_mv Host-directed antivirals A realistic alternative to fight Zika virus
title Host-directed antivirals A realistic alternative to fight Zika virus
spellingShingle Host-directed antivirals A realistic alternative to fight Zika virus
Saiz Calahorra, Juan Carlos
Flavivirus
Zika virus
Therapy
Host-directed antivirals
title_short Host-directed antivirals A realistic alternative to fight Zika virus
title_full Host-directed antivirals A realistic alternative to fight Zika virus
title_fullStr Host-directed antivirals A realistic alternative to fight Zika virus
title_full_unstemmed Host-directed antivirals A realistic alternative to fight Zika virus
title_sort Host-directed antivirals A realistic alternative to fight Zika virus
dc.creator.none.fl_str_mv Saiz Calahorra, Juan Carlos
Jiménez de Oya, Nereida
Blázquez, Ana B.
Escribano-Romero, Estela
Martín-Acebes, M. A.
author Saiz Calahorra, Juan Carlos
author_facet Saiz Calahorra, Juan Carlos
Jiménez de Oya, Nereida
Blázquez, Ana B.
Escribano-Romero, Estela
Martín-Acebes, M. A.
author_role author
author2 Jiménez de Oya, Nereida
Blázquez, Ana B.
Escribano-Romero, Estela
Martín-Acebes, M. A.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Escribano-Romero, Estela [0000-0002-5036-7607]
Jiménez de Oya, Nereida [0000-0003-3129-813X]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Flavivirus
Zika virus
Therapy
Host-directed antivirals
topic Flavivirus
Zika virus
Therapy
Host-directed antivirals
description Zika virus (ZIKV), a mosquito-borne flavivirus, was an almost neglected pathogen until its introduction in the Americas in 2015, where it has been responsible for a threat to global health, causing a great social and sanitary alarm due to its increased virulence, rapid spread, and an association with severe neurological and ophthalmological complications. Currently, no specific antiviral therapy against ZIKV is available, and treatments are palliative and mainly directed toward the relief of symptoms, such as fever and rash, by administering antipyretics, anti-histamines, and fluids for dehydration. Nevertheless, lately, search for antivirals has been a major aim in ZIKV investigations. To do so, screening of libraries from different sources, testing of natural compounds, and repurposing of drugs with known antiviral activity have allowed the identification of several antiviral candidates directed to both viral (structural proteins and enzymes) and cellular elements. Here, we present an updated review of current knowledge about anti-ZIKV strategies, focusing on host-directed antivirals as a realistic alternative to combat ZIKV infection.
publishDate 2018
dc.date.none.fl_str_mv 2018
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/291200
url http://hdl.handle.net/10261/291200
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Departamento de Biotecnología
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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