Análisis de microbiota, disfunción telomérica y microARNs en el Cáncer Colorrectal y en el Cáncer No Microcítico de Pulmón. Influencia del Índice de Masa Corporal

Colorectal cancer (CRC) and non-small cell lung cancer (NSCLC) are among the types of malignancies with major incidence and mortality worldwide. Overweight and obesity have been linked to a higher risk of developing these pathologies, due to the existence of common mechanisms such as chronic inflamm...

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Detalhes bibliográficos
Autor: Tesolato, Sofía Elena
Formato: tesis doctoral
Fecha de publicación:2026
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:español
OAI Identifier:oai:docta.ucm.es:20.500.14352/132424
Acesso em linha:https://hdl.handle.net/20.500.14352/132424
Access Level:acceso abierto
Palavra-chave:612.015(043.2)
Bioquímica (Farmacia)
2403 Bioquímica
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spelling Análisis de microbiota, disfunción telomérica y microARNs en el Cáncer Colorrectal y en el Cáncer No Microcítico de Pulmón. Influencia del Índice de Masa CorporalAnalysis of microbiota, telomeric dysfunction and microRNAs in Colorectal Cancer and in Non-Small Cell Lung Cancer. Influence of Body Mass IndexTesolato, Sofía Elena612.015(043.2)Bioquímica (Farmacia)2403 BioquímicaColorectal cancer (CRC) and non-small cell lung cancer (NSCLC) are among the types of malignancies with major incidence and mortality worldwide. Overweight and obesity have been linked to a higher risk of developing these pathologies, due to the existence of common mechanisms such as chronic inflammation. Dysbiosis or imbalance of the gut microbiota seems to actively participate in oncogenesis, both at a local level and in distant locations like the lungs. Telomere dysfunction, namely the shortening of telomeres, has also been associated with cancer pathogeny and to the development of cancer-related diseases like idiopathic pulmonary fibrosis (IPF) and other types of interstitial lung diseases (ILDs). Moreover, evidence exists of dysregulation in microRNA (miRNA or miR) expression in various diseases like obesity and neoplasms. Nevertheless, the specific role of dysbiosis, telomere function and miRNA expression in the relationship between obesity and cancer is not fully understood...Universidad Complutense de MadridIniesta Serrano, María PilarUniversidad Complutense de Madrid20262026-02-1620262026-02-16doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/132424reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Españolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1324242026-06-02T12:44:21Z
dc.title.none.fl_str_mv Análisis de microbiota, disfunción telomérica y microARNs en el Cáncer Colorrectal y en el Cáncer No Microcítico de Pulmón. Influencia del Índice de Masa Corporal
Analysis of microbiota, telomeric dysfunction and microRNAs in Colorectal Cancer and in Non-Small Cell Lung Cancer. Influence of Body Mass Index
title Análisis de microbiota, disfunción telomérica y microARNs en el Cáncer Colorrectal y en el Cáncer No Microcítico de Pulmón. Influencia del Índice de Masa Corporal
spellingShingle Análisis de microbiota, disfunción telomérica y microARNs en el Cáncer Colorrectal y en el Cáncer No Microcítico de Pulmón. Influencia del Índice de Masa Corporal
Tesolato, Sofía Elena
612.015(043.2)
Bioquímica (Farmacia)
2403 Bioquímica
title_short Análisis de microbiota, disfunción telomérica y microARNs en el Cáncer Colorrectal y en el Cáncer No Microcítico de Pulmón. Influencia del Índice de Masa Corporal
title_full Análisis de microbiota, disfunción telomérica y microARNs en el Cáncer Colorrectal y en el Cáncer No Microcítico de Pulmón. Influencia del Índice de Masa Corporal
title_fullStr Análisis de microbiota, disfunción telomérica y microARNs en el Cáncer Colorrectal y en el Cáncer No Microcítico de Pulmón. Influencia del Índice de Masa Corporal
title_full_unstemmed Análisis de microbiota, disfunción telomérica y microARNs en el Cáncer Colorrectal y en el Cáncer No Microcítico de Pulmón. Influencia del Índice de Masa Corporal
title_sort Análisis de microbiota, disfunción telomérica y microARNs en el Cáncer Colorrectal y en el Cáncer No Microcítico de Pulmón. Influencia del Índice de Masa Corporal
dc.creator.none.fl_str_mv Tesolato, Sofía Elena
author Tesolato, Sofía Elena
author_facet Tesolato, Sofía Elena
author_role author
dc.contributor.none.fl_str_mv Iniesta Serrano, María Pilar
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 612.015(043.2)
Bioquímica (Farmacia)
2403 Bioquímica
topic 612.015(043.2)
Bioquímica (Farmacia)
2403 Bioquímica
description Colorectal cancer (CRC) and non-small cell lung cancer (NSCLC) are among the types of malignancies with major incidence and mortality worldwide. Overweight and obesity have been linked to a higher risk of developing these pathologies, due to the existence of common mechanisms such as chronic inflammation. Dysbiosis or imbalance of the gut microbiota seems to actively participate in oncogenesis, both at a local level and in distant locations like the lungs. Telomere dysfunction, namely the shortening of telomeres, has also been associated with cancer pathogeny and to the development of cancer-related diseases like idiopathic pulmonary fibrosis (IPF) and other types of interstitial lung diseases (ILDs). Moreover, evidence exists of dysregulation in microRNA (miRNA or miR) expression in various diseases like obesity and neoplasms. Nevertheless, the specific role of dysbiosis, telomere function and miRNA expression in the relationship between obesity and cancer is not fully understood...
publishDate 2026
dc.date.none.fl_str_mv 2026
2026-02-16
2026
2026-02-16
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/132424
url https://hdl.handle.net/20.500.14352/132424
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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