The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii

Cell growth is tightly coupled to nutrient availability. The target of rapamycin (TOR) kinase transmits nutritional and environmental cues to the cellular growth machinery. TOR functions in two distinct multiprotein complexes, termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2). While the structu...

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Autores: Pérez Pérez, María Esther, Couso Liáñez, Inmaculada Concepción, Crespo, José Luis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/67882
Acceso en línea:http://hdl.handle.net/11441/67882
https://doi.org/10.3390/biom7030054
Access Level:acceso abierto
Palabra clave:target of rapamycin (TOR)
rapamycin
FKBP12
Chlamydomonas
algae
autophagy
lipid metabolism
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spelling The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtiiPérez Pérez, María EstherCouso Liáñez, Inmaculada ConcepciónCrespo, José Luistarget of rapamycin (TOR)rapamycinFKBP12Chlamydomonasalgaeautophagylipid metabolismCell growth is tightly coupled to nutrient availability. The target of rapamycin (TOR) kinase transmits nutritional and environmental cues to the cellular growth machinery. TOR functions in two distinct multiprotein complexes, termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2). While the structure and functions of TORC1 are highly conserved in all eukaryotes, including algae and plants, TORC2 core proteins seem to be missing in photosynthetic organisms. TORC1 controls cell growth by promoting anabolic processes, including protein synthesis and ribosome biogenesis, and inhibiting catabolic processes such as autophagy. Recent studies identified rapamycin-sensitive TORC1 signaling regulating cell growth, autophagy, lipid metabolism, and central metabolic pathways in the model unicellular green alga <i>Chlamydomonas reinhardtii</i>. The central role that microalgae play in global biomass production, together with the high biotechnological potential of these organisms in biofuel production, has drawn attention to the study of proteins that regulate cell growth such as the TOR kinase. In this review we discuss the recent progress on TOR signaling in algae.España, MINECO BFU2015-68216-PMDPIBioquímica Vegetal y Biología MolecularMinisterio de Economía y Competitividad (MINECO). España2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/11441/67882https://doi.org/10.3390/biom7030054reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésBiomolecules, 7 (3), 54-54.BFU2015-68216-Phttps://doi.org/10.3390/biom7030054info:eu-repo/semantics/openAccessoai:idus.us.es:11441/678822026-06-17T12:51:07Z
dc.title.none.fl_str_mv The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii
title The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii
spellingShingle The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii
Pérez Pérez, María Esther
target of rapamycin (TOR)
rapamycin
FKBP12
Chlamydomonas
algae
autophagy
lipid metabolism
title_short The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii
title_full The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii
title_fullStr The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii
title_full_unstemmed The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii
title_sort The TOR Signaling Network in the Model Unicellular Green Alga Chlamydomonas reinhardtii
dc.creator.none.fl_str_mv Pérez Pérez, María Esther
Couso Liáñez, Inmaculada Concepción
Crespo, José Luis
author Pérez Pérez, María Esther
author_facet Pérez Pérez, María Esther
Couso Liáñez, Inmaculada Concepción
Crespo, José Luis
author_role author
author2 Couso Liáñez, Inmaculada Concepción
Crespo, José Luis
author2_role author
author
dc.contributor.none.fl_str_mv Bioquímica Vegetal y Biología Molecular
Ministerio de Economía y Competitividad (MINECO). España
dc.subject.none.fl_str_mv target of rapamycin (TOR)
rapamycin
FKBP12
Chlamydomonas
algae
autophagy
lipid metabolism
topic target of rapamycin (TOR)
rapamycin
FKBP12
Chlamydomonas
algae
autophagy
lipid metabolism
description Cell growth is tightly coupled to nutrient availability. The target of rapamycin (TOR) kinase transmits nutritional and environmental cues to the cellular growth machinery. TOR functions in two distinct multiprotein complexes, termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2). While the structure and functions of TORC1 are highly conserved in all eukaryotes, including algae and plants, TORC2 core proteins seem to be missing in photosynthetic organisms. TORC1 controls cell growth by promoting anabolic processes, including protein synthesis and ribosome biogenesis, and inhibiting catabolic processes such as autophagy. Recent studies identified rapamycin-sensitive TORC1 signaling regulating cell growth, autophagy, lipid metabolism, and central metabolic pathways in the model unicellular green alga <i>Chlamydomonas reinhardtii</i>. The central role that microalgae play in global biomass production, together with the high biotechnological potential of these organisms in biofuel production, has drawn attention to the study of proteins that regulate cell growth such as the TOR kinase. In this review we discuss the recent progress on TOR signaling in algae.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11441/67882
https://doi.org/10.3390/biom7030054
url http://hdl.handle.net/11441/67882
https://doi.org/10.3390/biom7030054
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biomolecules, 7 (3), 54-54.
BFU2015-68216-P
https://doi.org/10.3390/biom7030054
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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