Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows

Ischemic stroke represents one of the most prevalent pathologies in humans and is a leading cause of death and disability. Anti-thrombolytic therapy with tissue plasminogen activator (t-PA) and surgical thrombectomy are the primary treatments to recanalize occluded vessels and normalize the blood fl...

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Detalles Bibliográficos
Autores: González Nieto, Daniel, Fernández Serra, Rocío, Pérez Rigueiro, José, Panetsos Petrova, Fivos, Martinez Murillo, Ricardo, Guinea, Gustavo V.
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/7901
Acceso en línea:https://hdl.handle.net/20.500.14352/7901
Access Level:acceso abierto
Palabra clave:stroke
brain ischemia
inflammation
excitotoxicity
oxidative stress
spreading depression
neuroprotection
drug delivery
biomaterials
polymers
nanoparticles
hydrogels
Neurociencias (Medicina)
2490 Neurociencias
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spelling Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time WindowsGonzález Nieto, DanielFernández Serra, RocíoPérez Rigueiro, JoséPanetsos Petrova, FivosMartinez Murillo, RicardoGuinea, Gustavo V.strokebrain ischemiainflammationexcitotoxicityoxidative stressspreading depressionneuroprotectiondrug deliverybiomaterialspolymersnanoparticleshydrogelsNeurociencias (Medicina)2490 NeurocienciasIschemic stroke represents one of the most prevalent pathologies in humans and is a leading cause of death and disability. Anti-thrombolytic therapy with tissue plasminogen activator (t-PA) and surgical thrombectomy are the primary treatments to recanalize occluded vessels and normalize the blood flow in ischemic and peri-ischemic regions. A large majority of stroke patients are refractory to treatment or are not eligible due to the narrow time window of therapeutic efficacy. In recent decades, we have significantly increased our knowledge of the molecular and cellular mechanisms that inexorably lead to progressive damage in infarcted and peri-lesional brain areas. As a result, promising neuroprotective targets have been identified and exploited in several stroke models. However, these considerable advances have been unsuccessful in clinical contexts. This lack of clinical translatability and the emerging use of biomaterials in different biomedical disciplines have contributed to developing a new class of biomaterial-based systems for the better control of drug delivery in cerebral disorders. These systems are based on specific polymer formulations structured in nanoparticles and hydrogels that can be administered through different routes and, in general, bring the concentrations of drugs to therapeutic levels for prolonged times. In this review, we first provide the general context of the molecular and cellular mechanisms impaired by cerebral ischemia, highlighting the role of excitotoxicity, inflammation, oxidative stress, and depolarization waves as the main pathways and targets to promote neuroprotection avoiding neuronal dysfunction. In the second part, we discuss the versatile role played by distinct biomaterials and formats to support the sustained administration of particular compounds to neuroprotect the cerebral tissue at risk of damage.MDPIUniversidad Complutense de Madrid20202020-04-2620202020-04-26journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/7901reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/79012026-06-02T12:44:21Z
dc.title.none.fl_str_mv Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows
title Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows
spellingShingle Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows
González Nieto, Daniel
stroke
brain ischemia
inflammation
excitotoxicity
oxidative stress
spreading depression
neuroprotection
drug delivery
biomaterials
polymers
nanoparticles
hydrogels
Neurociencias (Medicina)
2490 Neurociencias
title_short Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows
title_full Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows
title_fullStr Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows
title_full_unstemmed Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows
title_sort Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows
dc.creator.none.fl_str_mv González Nieto, Daniel
Fernández Serra, Rocío
Pérez Rigueiro, José
Panetsos Petrova, Fivos
Martinez Murillo, Ricardo
Guinea, Gustavo V.
author González Nieto, Daniel
author_facet González Nieto, Daniel
Fernández Serra, Rocío
Pérez Rigueiro, José
Panetsos Petrova, Fivos
Martinez Murillo, Ricardo
Guinea, Gustavo V.
author_role author
author2 Fernández Serra, Rocío
Pérez Rigueiro, José
Panetsos Petrova, Fivos
Martinez Murillo, Ricardo
Guinea, Gustavo V.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv stroke
brain ischemia
inflammation
excitotoxicity
oxidative stress
spreading depression
neuroprotection
drug delivery
biomaterials
polymers
nanoparticles
hydrogels
Neurociencias (Medicina)
2490 Neurociencias
topic stroke
brain ischemia
inflammation
excitotoxicity
oxidative stress
spreading depression
neuroprotection
drug delivery
biomaterials
polymers
nanoparticles
hydrogels
Neurociencias (Medicina)
2490 Neurociencias
description Ischemic stroke represents one of the most prevalent pathologies in humans and is a leading cause of death and disability. Anti-thrombolytic therapy with tissue plasminogen activator (t-PA) and surgical thrombectomy are the primary treatments to recanalize occluded vessels and normalize the blood flow in ischemic and peri-ischemic regions. A large majority of stroke patients are refractory to treatment or are not eligible due to the narrow time window of therapeutic efficacy. In recent decades, we have significantly increased our knowledge of the molecular and cellular mechanisms that inexorably lead to progressive damage in infarcted and peri-lesional brain areas. As a result, promising neuroprotective targets have been identified and exploited in several stroke models. However, these considerable advances have been unsuccessful in clinical contexts. This lack of clinical translatability and the emerging use of biomaterials in different biomedical disciplines have contributed to developing a new class of biomaterial-based systems for the better control of drug delivery in cerebral disorders. These systems are based on specific polymer formulations structured in nanoparticles and hydrogels that can be administered through different routes and, in general, bring the concentrations of drugs to therapeutic levels for prolonged times. In this review, we first provide the general context of the molecular and cellular mechanisms impaired by cerebral ischemia, highlighting the role of excitotoxicity, inflammation, oxidative stress, and depolarization waves as the main pathways and targets to promote neuroprotection avoiding neuronal dysfunction. In the second part, we discuss the versatile role played by distinct biomaterials and formats to support the sustained administration of particular compounds to neuroprotect the cerebral tissue at risk of damage.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-04-26
2020
2020-04-26
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/7901
url https://hdl.handle.net/20.500.14352/7901
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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