Cobalt-catalyzed C−H annulation of aliphatic amides with maleimides: Chemodivergent (4+1) and (3+2) pathways
Chemodivergent C–H annulation of aliphatic amides with maleimides has been achieved under cobaltcatalysis, enabling access to distinct (4 + 1) and (3 + 2) outcomes. These protocols, utilizing a readily available CoII-catalyst, deliver a powerful strategy for the synthesis of a diverse range of spiro...
| Autores: | , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2026 |
| País: | España |
| Recursos: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:biblosearchi::86009ce49afab625d6380703556c1439 |
| Acesso em linha: | https://hdl.handle.net/10486/759100 https://dx.doi.org/10.1039/D6QO00080K |
| Access Level: | acceso abierto |
| Palavra-chave: | Amides Aspartame Catalysis Cobalt compounds Química |
| Resumo: | Chemodivergent C–H annulation of aliphatic amides with maleimides has been achieved under cobaltcatalysis, enabling access to distinct (4 + 1) and (3 + 2) outcomes. These protocols, utilizing a readily available CoII-catalyst, deliver a powerful strategy for the synthesis of a diverse range of spiro-γ-lactams (spiropyrrolidin-2-ones) and bicyclic pyrrolidin-2,5-diones. The combination of DFT and experimental studies provides mechanistic insight into both processes, revealing the origins of their diastereo- and chemoselectivity |
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