First year after surgery is the optimal period to define early prosthetic valve endocarditis: a cohort study

Background The definition of early prosthetic valve endocarditis (PVE) remains controversial. This study aims to refine the definition of early PVE by analysing data from the Spanish endocarditis registry (Spanish Collaboration on Endocarditis).Methods From 2008 to 2022, 1305 consecutive cases of PV...

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Autores: Calderón Parra, Jorge, Escrihuela-Vidal, Francesc, Cuervo Requena, Guillermo, López Azor, Juan Carlos, Muñoz, Patricia, Machado, Marina, Marín, Mercedes, Rodríguez Esteban, María Ángeles, Rodríguez García, Raquel, Gutiérrez, Francisco, Miró Meda, José M. (José María), 1956-, Goenaga, Miguel Ángel, Goikoetxea Agirre, Josune, Alarcón, Arístides de, Vidal Bonnet, Laura, Ramos Martínez, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/222393
Acceso en línea:https://hdl.handle.net/2445/222393
Access Level:acceso abierto
Palabra clave:Endocarditis
Cirurgia asèptica i antisèptica
Cirurgia cardiovascular
Surgery aseptic and antiseptic
Cardiovascular surgery
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spelling First year after surgery is the optimal period to define early prosthetic valve endocarditis: a cohort studyCalderón Parra, JorgeEscrihuela-Vidal, FrancescCuervo Requena, GuillermoLópez Azor, Juan CarlosMuñoz, PatriciaMachado, MarinaMarín, MercedesRodríguez Esteban, María ÁngelesRodríguez García, RaquelGutiérrez, FranciscoMiró Meda, José M. (José María), 1956-Goenaga, Miguel ÁngelGoikoetxea Agirre, JosuneAlarcón, Arístides deVidal Bonnet, LauraRamos Martínez, AntonioEndocarditisCirurgia asèptica i antisèpticaCirurgia cardiovascularEndocarditisSurgery aseptic and antisepticCardiovascular surgeryBackground The definition of early prosthetic valve endocarditis (PVE) remains controversial. This study aims to refine the definition of early PVE by analysing data from the Spanish endocarditis registry (Spanish Collaboration on Endocarditis).Methods From 2008 to 2022, 1305 consecutive cases of PVE were included. The objective was to identify the time period that best defined early PVE by comparing the frequency of cases due to nosocomial micro-organisms and the frequency of intracardiac complications. For this purpose, the periods most frequently considered in the literature were selected: the first 4, 6 or 12 months after surgery. Each of these three periods was compared with a period immediately thereafter.Results Most cases of PVE diagnosed within the first year were caused by nosocomial pathogens, such as coagulase-negative staphylococci (CoNS) (236 cases, 49.3 %) and Candida spp (23 cases, 4.8 %) and was associated with higher rates of intracardiac complications (252 cases 52.6%). In patients diagnosed after the first year, these figures were 197 cases (23.8%, p<0.001); 10 cases (1.2%, p<0.001) and 298 cases (36.1%, p<0.001), respectively. No significant differences were found between the first 4 months and the 5th-6th months. When comparing cases diagnosed in the first 6 months with those diagnosed during the 7th and 12th months, there was a higher prevalence of cases due to CoNS (186 cases, 52.1% vs 50 cases 41%; p=0.034). Hospital mortality among patients who did not undergo surgery due to lack of indication was similar in those diagnosed during or after the first 6 months (17.1% vs 13.8%; p=0.663, respectively).Conclusions We consider that the first year after surgery is the most appropriate period for defining early PVE. Our results question whether cases diagnosed in the first 6 months after surgery constitute cases of early EVP and the need for valve replacement, as postulated by European guidelines.BMJ2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/222393Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1136/openhrt-2025-003378Open Heart, 2025, vol. 12, num. 1https://doi.org/10.1136/openhrt-2025-003378cc by-nc (c) Calderón Parra, Jorge et al, 2025http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2223932026-05-29T05:05:01Z
dc.title.none.fl_str_mv First year after surgery is the optimal period to define early prosthetic valve endocarditis: a cohort study
title First year after surgery is the optimal period to define early prosthetic valve endocarditis: a cohort study
spellingShingle First year after surgery is the optimal period to define early prosthetic valve endocarditis: a cohort study
Calderón Parra, Jorge
Endocarditis
Cirurgia asèptica i antisèptica
Cirurgia cardiovascular
Endocarditis
Surgery aseptic and antiseptic
Cardiovascular surgery
title_short First year after surgery is the optimal period to define early prosthetic valve endocarditis: a cohort study
title_full First year after surgery is the optimal period to define early prosthetic valve endocarditis: a cohort study
title_fullStr First year after surgery is the optimal period to define early prosthetic valve endocarditis: a cohort study
title_full_unstemmed First year after surgery is the optimal period to define early prosthetic valve endocarditis: a cohort study
title_sort First year after surgery is the optimal period to define early prosthetic valve endocarditis: a cohort study
dc.creator.none.fl_str_mv Calderón Parra, Jorge
Escrihuela-Vidal, Francesc
Cuervo Requena, Guillermo
López Azor, Juan Carlos
Muñoz, Patricia
Machado, Marina
Marín, Mercedes
Rodríguez Esteban, María Ángeles
Rodríguez García, Raquel
Gutiérrez, Francisco
Miró Meda, José M. (José María), 1956-
Goenaga, Miguel Ángel
Goikoetxea Agirre, Josune
Alarcón, Arístides de
Vidal Bonnet, Laura
Ramos Martínez, Antonio
author Calderón Parra, Jorge
author_facet Calderón Parra, Jorge
Escrihuela-Vidal, Francesc
Cuervo Requena, Guillermo
López Azor, Juan Carlos
Muñoz, Patricia
Machado, Marina
Marín, Mercedes
Rodríguez Esteban, María Ángeles
Rodríguez García, Raquel
Gutiérrez, Francisco
Miró Meda, José M. (José María), 1956-
Goenaga, Miguel Ángel
Goikoetxea Agirre, Josune
Alarcón, Arístides de
Vidal Bonnet, Laura
Ramos Martínez, Antonio
author_role author
author2 Escrihuela-Vidal, Francesc
Cuervo Requena, Guillermo
López Azor, Juan Carlos
Muñoz, Patricia
Machado, Marina
Marín, Mercedes
Rodríguez Esteban, María Ángeles
Rodríguez García, Raquel
Gutiérrez, Francisco
Miró Meda, José M. (José María), 1956-
Goenaga, Miguel Ángel
Goikoetxea Agirre, Josune
Alarcón, Arístides de
Vidal Bonnet, Laura
Ramos Martínez, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Endocarditis
Cirurgia asèptica i antisèptica
Cirurgia cardiovascular
Endocarditis
Surgery aseptic and antiseptic
Cardiovascular surgery
topic Endocarditis
Cirurgia asèptica i antisèptica
Cirurgia cardiovascular
Endocarditis
Surgery aseptic and antiseptic
Cardiovascular surgery
description Background The definition of early prosthetic valve endocarditis (PVE) remains controversial. This study aims to refine the definition of early PVE by analysing data from the Spanish endocarditis registry (Spanish Collaboration on Endocarditis).Methods From 2008 to 2022, 1305 consecutive cases of PVE were included. The objective was to identify the time period that best defined early PVE by comparing the frequency of cases due to nosocomial micro-organisms and the frequency of intracardiac complications. For this purpose, the periods most frequently considered in the literature were selected: the first 4, 6 or 12 months after surgery. Each of these three periods was compared with a period immediately thereafter.Results Most cases of PVE diagnosed within the first year were caused by nosocomial pathogens, such as coagulase-negative staphylococci (CoNS) (236 cases, 49.3 %) and Candida spp (23 cases, 4.8 %) and was associated with higher rates of intracardiac complications (252 cases 52.6%). In patients diagnosed after the first year, these figures were 197 cases (23.8%, p<0.001); 10 cases (1.2%, p<0.001) and 298 cases (36.1%, p<0.001), respectively. No significant differences were found between the first 4 months and the 5th-6th months. When comparing cases diagnosed in the first 6 months with those diagnosed during the 7th and 12th months, there was a higher prevalence of cases due to CoNS (186 cases, 52.1% vs 50 cases 41%; p=0.034). Hospital mortality among patients who did not undergo surgery due to lack of indication was similar in those diagnosed during or after the first 6 months (17.1% vs 13.8%; p=0.663, respectively).Conclusions We consider that the first year after surgery is the most appropriate period for defining early PVE. Our results question whether cases diagnosed in the first 6 months after surgery constitute cases of early EVP and the need for valve replacement, as postulated by European guidelines.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/222393
url https://hdl.handle.net/2445/222393
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1136/openhrt-2025-003378
Open Heart, 2025, vol. 12, num. 1
https://doi.org/10.1136/openhrt-2025-003378
dc.rights.none.fl_str_mv cc by-nc (c) Calderón Parra, Jorge et al, 2025
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Calderón Parra, Jorge et al, 2025
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv BMJ
publisher.none.fl_str_mv BMJ
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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