Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task

Background. According to the aberrant salience proposal, reward processing abnormality, specifically erroneous reward prediction error (RPE) signaling due to stimulus-independent release of dopamine, underlies delusions in schizophrenia. However, no studies to date have examined RPE-associated brain...

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Autores: García León, María Ángeles, Fuentes Claramonte, Paola, Gee, Abigail, Ramiro-Sousa, Nuria, Soler Vidal, Joan, Pomarol Clotet, Edith
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/170352
Acceso en línea:https://hdl.handle.net/11441/170352
https://doi.org/10.1017/S0033291724003258
Access Level:acceso abierto
Palabra clave:Schizophrenia
Delusions
Referentiality
Reward
Reward prediction error
fMRI
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spelling Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward taskGarcía León, María ÁngelesFuentes Claramonte, PaolaGee, AbigailRamiro-Sousa, NuriaSoler Vidal, JoanPomarol Clotet, EdithSchizophreniaDelusionsReferentialityRewardReward prediction errorfMRIBackground. According to the aberrant salience proposal, reward processing abnormality, specifically erroneous reward prediction error (RPE) signaling due to stimulus-independent release of dopamine, underlies delusions in schizophrenia. However, no studies to date have examined RPE-associated brain activations in relation to this symptom. Methods. Seventy-eight patients with a DSM-5 diagnosis of schizophrenia/schizoaffective disorder and 43 healthy individuals underwent fMRI while they performed a probabilistic monetary reward task designed to generate a measure of RPE. Ratings of delusions and referentiality were made in the patients. Results. Using whole-brain, voxel-based analysis, schizophrenia patients showed only minor differences in RPE-associated activation compared to healthy controls. Within the patient group, however, severity of delusions was inversely associated with RPE-associated activation in areas including the caudate nucleus, the thalamus and the left pallidum, as well as the lateral frontal cortex bilaterally, the pre- and postcentral gyrus and supplementary motor area, the middle cingulate gyrus, and parts of the temporal and parietal cortex. A broadly similar pattern of association was seen for referentiality. Conclusions. According to this study, while patients with schizophrenia as a group do not show marked alterations in RPE signaling, delusions and referentiality are associated with reduced activation in parts of the prefrontal cortex and the basal ganglia, though not specifically the ventral striatum. The direction of the changes is on the face of it contrary to that predicted by aberrant salience theory.Cambridge University PressPersonalidad, Evaluación y Tratamiento PsicológicosGeneralitat de CatalunyaEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)Ministerio de Ciencia e Innovación (MICIN). EspañaMinisterio de Economía y Competitividad (MINECO). España2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11441/170352https://doi.org/10.1017/S0033291724003258reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésPsychological Medicine, 55, e55.2014-SGR-15732017-SGR-12712021SGR01475CD19/00149CD22/00106PID2022-138692NA-I00PID2021 124302NB-C22https://doi.org/10.1017/S0033291724003258info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1703522026-06-17T12:51:07Z
dc.title.none.fl_str_mv Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task
title Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task
spellingShingle Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task
García León, María Ángeles
Schizophrenia
Delusions
Referentiality
Reward
Reward prediction error
fMRI
title_short Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task
title_full Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task
title_fullStr Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task
title_full_unstemmed Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task
title_sort Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task
dc.creator.none.fl_str_mv García León, María Ángeles
Fuentes Claramonte, Paola
Gee, Abigail
Ramiro-Sousa, Nuria
Soler Vidal, Joan
Pomarol Clotet, Edith
author García León, María Ángeles
author_facet García León, María Ángeles
Fuentes Claramonte, Paola
Gee, Abigail
Ramiro-Sousa, Nuria
Soler Vidal, Joan
Pomarol Clotet, Edith
author_role author
author2 Fuentes Claramonte, Paola
Gee, Abigail
Ramiro-Sousa, Nuria
Soler Vidal, Joan
Pomarol Clotet, Edith
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Personalidad, Evaluación y Tratamiento Psicológicos
Generalitat de Catalunya
European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)
Ministerio de Ciencia e Innovación (MICIN). España
Ministerio de Economía y Competitividad (MINECO). España
dc.subject.none.fl_str_mv Schizophrenia
Delusions
Referentiality
Reward
Reward prediction error
fMRI
topic Schizophrenia
Delusions
Referentiality
Reward
Reward prediction error
fMRI
description Background. According to the aberrant salience proposal, reward processing abnormality, specifically erroneous reward prediction error (RPE) signaling due to stimulus-independent release of dopamine, underlies delusions in schizophrenia. However, no studies to date have examined RPE-associated brain activations in relation to this symptom. Methods. Seventy-eight patients with a DSM-5 diagnosis of schizophrenia/schizoaffective disorder and 43 healthy individuals underwent fMRI while they performed a probabilistic monetary reward task designed to generate a measure of RPE. Ratings of delusions and referentiality were made in the patients. Results. Using whole-brain, voxel-based analysis, schizophrenia patients showed only minor differences in RPE-associated activation compared to healthy controls. Within the patient group, however, severity of delusions was inversely associated with RPE-associated activation in areas including the caudate nucleus, the thalamus and the left pallidum, as well as the lateral frontal cortex bilaterally, the pre- and postcentral gyrus and supplementary motor area, the middle cingulate gyrus, and parts of the temporal and parietal cortex. A broadly similar pattern of association was seen for referentiality. Conclusions. According to this study, while patients with schizophrenia as a group do not show marked alterations in RPE signaling, delusions and referentiality are associated with reduced activation in parts of the prefrontal cortex and the basal ganglia, though not specifically the ventral striatum. The direction of the changes is on the face of it contrary to that predicted by aberrant salience theory.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/170352
https://doi.org/10.1017/S0033291724003258
url https://hdl.handle.net/11441/170352
https://doi.org/10.1017/S0033291724003258
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Psychological Medicine, 55, e55.
2014-SGR-1573
2017-SGR-1271
2021SGR01475
CD19/00149
CD22/00106
PID2022-138692NA-I00
PID2021 124302NB-C22
https://doi.org/10.1017/S0033291724003258
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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