Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability

Dendritic mesoporous bioactive glass nanoparticles (DMBGNs) with unique three-dimensional structures are attracting increasing attention for biomedical applications. However, it is still challenging to tune the chemical composition of DMBGNs. In this work, we provide for the first time a feasible po...

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Detalhes bibliográficos
Autores: Xu, Zhiyan, Keller, Emily, Beltrán, Ana M., Zheng, Kai, Boccaccini, Aldo R.
Formato: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2023
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/148631
Acesso em linha:https://hdl.handle.net/11441/148631
https://doi.org/10.1016/j.jnoncrysol.2023.122578
Access Level:acceso abierto
Palavra-chave:Cerium
Bioactive glass
Dendritic mesoporous nanoparticle
Bioactivity
Drug delivery
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repository_id_str
spelling Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capabilityXu, ZhiyanKeller, EmilyBeltrán, Ana M.Zheng, KaiBoccaccini, Aldo R.CeriumBioactive glassDendritic mesoporous nanoparticleBioactivityDrug deliveryDendritic mesoporous bioactive glass nanoparticles (DMBGNs) with unique three-dimensional structures are attracting increasing attention for biomedical applications. However, it is still challenging to tune the chemical composition of DMBGNs. In this work, we provide for the first time a feasible post-impregnation approach to incorporate metallic ions (Ca and Ce) into dendritic mesoporous silica nanoparticles, resulting in SiO₂-CaO and SiO₂-CaO-CeO₂ (Ce-DMBGNs) without destroying the dendritic mesoporous topography. Both DMBGNs and Ce-DMBGNs were amorphous, negatively charged, with a hydrodynamic size of ∼200 nm. The synthesized DMBGNs and Ce-DMBGNs exhibited high bioactivity as evidenced by the rapid formation of hydroxyapatite (HA) after immersion in simulated body fluid (SBF) for 7 days. In addition, DMBGNs and Ce-DMBGNs showed high propolis loading efficiency and sustained release behavior. The results suggest that the developed Ce-DMBGNs have the potential to be used as a delivery vehicle of therapeutic ions and drugs in bone regeneration applications.CITIUS, central services of the Universidad de Sevilla (Spain)ElsevierIngeniería y Ciencia de los Materiales y del TransporteTEP123: Metalurgia e Ingeniería de los Materiales2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/148631https://doi.org/10.1016/j.jnoncrysol.2023.122578reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésJournal of Non-Crystalline Solids, 620 (122578).https://www.sciencedirect.com/science/article/pii/S0022309323004441info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1486312026-06-17T12:51:07Z
dc.title.none.fl_str_mv Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability
title Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability
spellingShingle Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability
Xu, Zhiyan
Cerium
Bioactive glass
Dendritic mesoporous nanoparticle
Bioactivity
Drug delivery
title_short Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability
title_full Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability
title_fullStr Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability
title_full_unstemmed Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability
title_sort Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability
dc.creator.none.fl_str_mv Xu, Zhiyan
Keller, Emily
Beltrán, Ana M.
Zheng, Kai
Boccaccini, Aldo R.
author Xu, Zhiyan
author_facet Xu, Zhiyan
Keller, Emily
Beltrán, Ana M.
Zheng, Kai
Boccaccini, Aldo R.
author_role author
author2 Keller, Emily
Beltrán, Ana M.
Zheng, Kai
Boccaccini, Aldo R.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ingeniería y Ciencia de los Materiales y del Transporte
TEP123: Metalurgia e Ingeniería de los Materiales
dc.subject.none.fl_str_mv Cerium
Bioactive glass
Dendritic mesoporous nanoparticle
Bioactivity
Drug delivery
topic Cerium
Bioactive glass
Dendritic mesoporous nanoparticle
Bioactivity
Drug delivery
description Dendritic mesoporous bioactive glass nanoparticles (DMBGNs) with unique three-dimensional structures are attracting increasing attention for biomedical applications. However, it is still challenging to tune the chemical composition of DMBGNs. In this work, we provide for the first time a feasible post-impregnation approach to incorporate metallic ions (Ca and Ce) into dendritic mesoporous silica nanoparticles, resulting in SiO₂-CaO and SiO₂-CaO-CeO₂ (Ce-DMBGNs) without destroying the dendritic mesoporous topography. Both DMBGNs and Ce-DMBGNs were amorphous, negatively charged, with a hydrodynamic size of ∼200 nm. The synthesized DMBGNs and Ce-DMBGNs exhibited high bioactivity as evidenced by the rapid formation of hydroxyapatite (HA) after immersion in simulated body fluid (SBF) for 7 days. In addition, DMBGNs and Ce-DMBGNs showed high propolis loading efficiency and sustained release behavior. The results suggest that the developed Ce-DMBGNs have the potential to be used as a delivery vehicle of therapeutic ions and drugs in bone regeneration applications.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/148631
https://doi.org/10.1016/j.jnoncrysol.2023.122578
url https://hdl.handle.net/11441/148631
https://doi.org/10.1016/j.jnoncrysol.2023.122578
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Non-Crystalline Solids, 620 (122578).
https://www.sciencedirect.com/science/article/pii/S0022309323004441
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.198674

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