Atypical, non-standard functions of the microtubule associated Tau protein

Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau's role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and aggregation in Alzheimer's disease (AD)...

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Detalhes bibliográficos
Autores: Sotiropoulos, Ioannis, Galassi, Marie-Christine, Silva, Joana M., Skoulakis, Efthimios, Wegmann, Susanne, Maina, Mahmoud B., Blum, David, Sayas, Carmen Laura, Mandelkow, Eva-Maria, Mandelkow, Eckhard, Spillantini, Maria G., Sousa, Nuno, Ávila, Jesús, Medina, Miguel, Mudher, Amrit, Buee, Luc
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/253672
Acesso em linha:http://hdl.handle.net/10261/253672
Access Level:acceso abierto
Palavra-chave:Tau, Alzheimer’s disease
Neuronal function
Pathology
Nucleus
Dendrites
Synapse
Subcellular localization
Tau isoform
Descrição
Resumo:Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau's role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and aggregation in Alzheimer's disease (AD) brains. In recent years, however, research efforts identified new interaction partners and different sub-cellular localizations for Tau suggesting additional roles beyond its standard function as microtubule regulating protein. Moreover, despite the increasing research focus on AD over the last decades, Tau was only recently considered as a promising therapeutic target for the treatment and prevention of AD as well as for neurological pathologies beyond AD e.g. epilepsy, excitotoxicity, and environmental stress. This review will focus on atypical, non-standard roles of Tau on neuronal function and dysfunction in AD and other neurological pathologies providing novel insights about neuroplastic and neuropathological implications of Tau in both the central and the peripheral nervous system.

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