Patient Stratification for Serum LDH Levels Reveals Distinct CLA+ T-Cell Cytokine Secretion in Response to HDM, Clinical Features and Allergic Comorbidities

Lactate dehydrogenase (LDH) is a serum biomarker well known to correlate with disease severity in atopic dermatitis (AD). The aim of this study was to explore the cutaneous immune responses and the clinical profile of AD patients in relation to serum LDH levels. To this end, 47 untreated, adult pati...

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Bibliographic Details
Authors: García Jiménez, Irene, Figueras Nart, Ignasi, Sans de San Nicolàs, Lídia, Curto Barredo, Laia, Bertolín Colilla, Marta, Bonfill Ortí, Montserrat, Díez Ribas, Sandra, Llobet del Pino, Alex, Guilabert Vidal, Antonio, Ryzhkova, Anna, Ferran, Marta, Pujol, Ramon M., Santamaria Babí, Luis F.
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/223114
Online Access:https://hdl.handle.net/2445/223114
Access Level:Open access
Keyword:Al·lèrgia
Dermatitis atòpica
Allergy
Atopic dermatitis
Description
Summary:Lactate dehydrogenase (LDH) is a serum biomarker well known to correlate with disease severity in atopic dermatitis (AD). The aim of this study was to explore the cutaneous immune responses and the clinical profile of AD patients in relation to serum LDH levels. To this end, 47 untreated, adult patients with moderate-to-severe AD were stratified by median levels of serum LDH. Circulating memory T-cell responses to house dust mite (HDM) extract, in the presence of autologous lesional epidermal cells, were compared between AD subgroups. The LDHhigh group exhibited significantly higher IL-13, IL-5 and IL-9 in vitro responses confined to the cutaneous lymphocyte-associated antigen (CLA)+ subset compared to LDHlow patients. Clinically, LDHhigh patients were younger and exhibited more severe disease, elevated eosinophil counts in their blood, increased total and specific IgE levels in their plasma, and a higher prevalence of allergic rhinitis. Our data suggests that high LDH levels identify a subgroup of AD patients with a specific immune and clinical profile, and highlight the potential of LDH as a clinical parameter that may enable patient stratification for treatment selection.

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