Fate of d‑fagomine after oral administration to rats

D-Fagomine is an iminosugar found in buckwheat that is capable of inhibiting the adhesion of potentially pathogenic bacteria to epithelial mucosa and of reducing postprandial blood glucose concentration. This paper evaluates the excretion and metabolism of orally administered D-fagomine in rats and...

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Autores: Amézqueta, Susana, Ramos Romero, Sara, Martínez-Guimet, C., Moreno, Albert, Hereu, Mercè, Torres Simón, Josep Lluís
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/162279
Acceso en línea:https://hdl.handle.net/2445/162279
Access Level:acceso abierto
Palabra clave:Glucòsids
Infeccions per escheríchia coli
Infeccions del tracte urinari
Glucosides
Escherichia coli infections
Urinary tract infections
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repository_id_str
spelling Fate of d‑fagomine after oral administration to ratsAmézqueta, SusanaRamos Romero, SaraMartínez-Guimet, C.Moreno, AlbertHereu, MercèTorres Simón, Josep LluísGlucòsidsInfeccions per escheríchia coliInfeccions del tracte urinariGlucosidesEscherichia coli infectionsUrinary tract infectionsD-Fagomine is an iminosugar found in buckwheat that is capable of inhibiting the adhesion of potentially pathogenic bacteria to epithelial mucosa and of reducing postprandial blood glucose concentration. This paper evaluates the excretion and metabolism of orally administered D-fagomine in rats and compares outcomes with the fate of 1-deoxynojirimycin. D-Fagomine and 1- deoxynojirimycin show similar absorption and excretion kinetics. D-Fagomine is partly absorbed (41-84%, dose 2 mg/kg body weight) and excreted in urine within 8 h while non-absorbed fraction is cleared in feces within 24 h. D-Fagomine is partially methylated (about 10% in urine and 3% in feces). The concentration of D-fagomine in urine from 1 to 6 h after administration is higher than 10 mg/L, the concentration that inhibits adhesion of Escherichia coli. Orally administered D-fagomine is partially absorbed and then rapidly excreted in urine were it reaches a concentration that may be protective against urinary tract infections.American Chemical Society2020202020172020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion7 p.application/pdfhttps://hdl.handle.net/2445/162279Articles publicats en revistes (Enginyeria Química i Química Analítica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1021/acs.jafc.7b01026Journal of Agricultural and Food Chemistry, 2017, vol. 65, num. 22, p. 4414-4420https://doi.org/10.1021/acs.jafc.7b01026(c) American Chemical Society , 2017info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1622792026-05-29T05:05:01Z
dc.title.none.fl_str_mv Fate of d‑fagomine after oral administration to rats
title Fate of d‑fagomine after oral administration to rats
spellingShingle Fate of d‑fagomine after oral administration to rats
Amézqueta, Susana
Glucòsids
Infeccions per escheríchia coli
Infeccions del tracte urinari
Glucosides
Escherichia coli infections
Urinary tract infections
title_short Fate of d‑fagomine after oral administration to rats
title_full Fate of d‑fagomine after oral administration to rats
title_fullStr Fate of d‑fagomine after oral administration to rats
title_full_unstemmed Fate of d‑fagomine after oral administration to rats
title_sort Fate of d‑fagomine after oral administration to rats
dc.creator.none.fl_str_mv Amézqueta, Susana
Ramos Romero, Sara
Martínez-Guimet, C.
Moreno, Albert
Hereu, Mercè
Torres Simón, Josep Lluís
author Amézqueta, Susana
author_facet Amézqueta, Susana
Ramos Romero, Sara
Martínez-Guimet, C.
Moreno, Albert
Hereu, Mercè
Torres Simón, Josep Lluís
author_role author
author2 Ramos Romero, Sara
Martínez-Guimet, C.
Moreno, Albert
Hereu, Mercè
Torres Simón, Josep Lluís
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Glucòsids
Infeccions per escheríchia coli
Infeccions del tracte urinari
Glucosides
Escherichia coli infections
Urinary tract infections
topic Glucòsids
Infeccions per escheríchia coli
Infeccions del tracte urinari
Glucosides
Escherichia coli infections
Urinary tract infections
description D-Fagomine is an iminosugar found in buckwheat that is capable of inhibiting the adhesion of potentially pathogenic bacteria to epithelial mucosa and of reducing postprandial blood glucose concentration. This paper evaluates the excretion and metabolism of orally administered D-fagomine in rats and compares outcomes with the fate of 1-deoxynojirimycin. D-Fagomine and 1- deoxynojirimycin show similar absorption and excretion kinetics. D-Fagomine is partly absorbed (41-84%, dose 2 mg/kg body weight) and excreted in urine within 8 h while non-absorbed fraction is cleared in feces within 24 h. D-Fagomine is partially methylated (about 10% in urine and 3% in feces). The concentration of D-fagomine in urine from 1 to 6 h after administration is higher than 10 mg/L, the concentration that inhibits adhesion of Escherichia coli. Orally administered D-fagomine is partially absorbed and then rapidly excreted in urine were it reaches a concentration that may be protective against urinary tract infections.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/162279
url https://hdl.handle.net/2445/162279
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1021/acs.jafc.7b01026
Journal of Agricultural and Food Chemistry, 2017, vol. 65, num. 22, p. 4414-4420
https://doi.org/10.1021/acs.jafc.7b01026
dc.rights.none.fl_str_mv (c) American Chemical Society , 2017
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Chemical Society , 2017
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Química i Química Analítica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.228081

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