Immunomodulatory lectin-like peptides for fish erythrocytes-targeting as potential antiviral drug delivery platforms
One of the challenges of science in disease prevention is optimizing drug and vaccine delivery. Until now, many strategies have been employed in this sector, but most are quite complex and labile. To overcome these limitations, great efforts are directed to coupling drugs to carriers, either of natu...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:255160 |
| Acceso en línea: | https://ddd.uab.cat/record/255160 https://dx.doi.org/urn:doi:10.3390/ijms222111821 |
| Access Level: | acceso abierto |
| Palabra clave: | Peptide Red blood cells Erythrocyte Drug delivery Ligand Prophylactic Therapeutic Cell-targeting Lectin Fish |
| id |
ES_75aea96d965f18ff64e2c8d2763fb5d5 |
|---|---|
| oai_identifier_str |
oai:ddd.uab.cat:255160 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Immunomodulatory lectin-like peptides for fish erythrocytes-targeting as potential antiviral drug delivery platformsSalvador-Mira, MariaChico, Veronica|||0000-0001-6983-2786Arostica, MónicaGuzmán, Fanny|||0000-0002-7829-0568Roher Armentia, Nerea|||0000-0002-6659-4038Perez Garcia-Estañ, Luis|||0000-0003-4078-8763Ortega-Villaizan, Maria del Mar|||0000-0003-2065-0601PeptideRed blood cellsErythrocyteDrug deliveryLigandProphylacticTherapeuticCell-targetingLectinFishOne of the challenges of science in disease prevention is optimizing drug and vaccine delivery. Until now, many strategies have been employed in this sector, but most are quite complex and labile. To overcome these limitations, great efforts are directed to coupling drugs to carriers, either of natural or synthetic origin. Among the most studied cell carriers are antigen-presenting cells (APCs), however, red blood cells (RBCs) are positioned as attractive carriers in drug delivery due to their abundance and availability in the body. Furthermore, fish RBCs have a nucleus and have been shown to have a strong involvement in modulating the immune response. In this study, we evaluated the binding of three peptides to rainbow trout RBCs, two lectin-like peptides and another derived from Plasmodium falciparum membrane protein, in order to take advantage of this peptide-RBCs binding to generate tools to improve the specificity, efficacy, immunostimulatory ef-fect, and safety of the antiviral therapeutic or prophylactic administration systems currently used.Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/255160https://dx.doi.org/urn:doi:10.3390/ijms222111821reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 639249Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 RTI2018-096957-B-C22open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2551602026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Immunomodulatory lectin-like peptides for fish erythrocytes-targeting as potential antiviral drug delivery platforms |
| title |
Immunomodulatory lectin-like peptides for fish erythrocytes-targeting as potential antiviral drug delivery platforms |
| spellingShingle |
Immunomodulatory lectin-like peptides for fish erythrocytes-targeting as potential antiviral drug delivery platforms Salvador-Mira, Maria Peptide Red blood cells Erythrocyte Drug delivery Ligand Prophylactic Therapeutic Cell-targeting Lectin Fish |
| title_short |
Immunomodulatory lectin-like peptides for fish erythrocytes-targeting as potential antiviral drug delivery platforms |
| title_full |
Immunomodulatory lectin-like peptides for fish erythrocytes-targeting as potential antiviral drug delivery platforms |
| title_fullStr |
Immunomodulatory lectin-like peptides for fish erythrocytes-targeting as potential antiviral drug delivery platforms |
| title_full_unstemmed |
Immunomodulatory lectin-like peptides for fish erythrocytes-targeting as potential antiviral drug delivery platforms |
| title_sort |
Immunomodulatory lectin-like peptides for fish erythrocytes-targeting as potential antiviral drug delivery platforms |
| dc.creator.none.fl_str_mv |
Salvador-Mira, Maria Chico, Veronica|||0000-0001-6983-2786 Arostica, Mónica Guzmán, Fanny|||0000-0002-7829-0568 Roher Armentia, Nerea|||0000-0002-6659-4038 Perez Garcia-Estañ, Luis|||0000-0003-4078-8763 Ortega-Villaizan, Maria del Mar|||0000-0003-2065-0601 |
| author |
Salvador-Mira, Maria |
| author_facet |
Salvador-Mira, Maria Chico, Veronica|||0000-0001-6983-2786 Arostica, Mónica Guzmán, Fanny|||0000-0002-7829-0568 Roher Armentia, Nerea|||0000-0002-6659-4038 Perez Garcia-Estañ, Luis|||0000-0003-4078-8763 Ortega-Villaizan, Maria del Mar|||0000-0003-2065-0601 |
| author_role |
author |
| author2 |
Chico, Veronica|||0000-0001-6983-2786 Arostica, Mónica Guzmán, Fanny|||0000-0002-7829-0568 Roher Armentia, Nerea|||0000-0002-6659-4038 Perez Garcia-Estañ, Luis|||0000-0003-4078-8763 Ortega-Villaizan, Maria del Mar|||0000-0003-2065-0601 |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia |
| dc.subject.none.fl_str_mv |
Peptide Red blood cells Erythrocyte Drug delivery Ligand Prophylactic Therapeutic Cell-targeting Lectin Fish |
| topic |
Peptide Red blood cells Erythrocyte Drug delivery Ligand Prophylactic Therapeutic Cell-targeting Lectin Fish |
| description |
One of the challenges of science in disease prevention is optimizing drug and vaccine delivery. Until now, many strategies have been employed in this sector, but most are quite complex and labile. To overcome these limitations, great efforts are directed to coupling drugs to carriers, either of natural or synthetic origin. Among the most studied cell carriers are antigen-presenting cells (APCs), however, red blood cells (RBCs) are positioned as attractive carriers in drug delivery due to their abundance and availability in the body. Furthermore, fish RBCs have a nucleus and have been shown to have a strong involvement in modulating the immune response. In this study, we evaluated the binding of three peptides to rainbow trout RBCs, two lectin-like peptides and another derived from Plasmodium falciparum membrane protein, in order to take advantage of this peptide-RBCs binding to generate tools to improve the specificity, efficacy, immunostimulatory ef-fect, and safety of the antiviral therapeutic or prophylactic administration systems currently used. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/255160 https://dx.doi.org/urn:doi:10.3390/ijms222111821 |
| url |
https://ddd.uab.cat/record/255160 https://dx.doi.org/urn:doi:10.3390/ijms222111821 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission https://doi.org/10.13039/501100000780 639249 Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 RTI2018-096957-B-C22 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
| instname_str |
Universitat Autònoma de Barcelona |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
| collection |
Dipòsit Digital de Documents de la UAB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869410997941305344 |
| score |
15.228081 |