Stress-related biomarkers and cognitive functioning in adolescents with ADHD
Our study aimed to explore whether stress-related hormones (hypothalamic-pituitary-adrenal [HPA] axis hormones and prolactin) are associated with poorer cognitive functioning in adolescents with attention deficit and hyperactivity disorder (ADHD) and to test the potential moderating effect of childh...
| Autores: | , , , , , , , , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Data de publicação: | 2022 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositório: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglês |
| OAI Identifier: | oai:ddd.uab.cat:291033 |
| Acesso em linha: | https://ddd.uab.cat/record/291033 https://dx.doi.org/urn:doi:10.1016/j.jpsychires.2022.02.041 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Adolescent Attention Deficit Disorder with Hyperactivity Biomarkers Child Child Abuse Cognition Female Humans Hydrocortisone Hypothalamo-Hypophyseal System Pituitary-Adrenal System Prolactin Saliva |
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Stress-related biomarkers and cognitive functioning in adolescents with ADHDEffect of childhood maltreatmentLlorens, Marta|||0000-0001-8532-0115Barba, MariaTorralbas Ortega, Jordi|||0000-0002-9423-9332Nadal i Alemany, Roser|||0000-0001-8972-2525Armario Garcia, Antonio|||0000-0001-9524-3635Gagliano, Humberto Antonio|||0000-0001-8727-9080Betriu, MariaUrraca Camps, Lara|||0000-0002-7800-0874Pujol, SusanaMontalvo Aguirrezabala, Itziar|||0000-0002-7320-5109Gracia Liso, Rebeca|||0000-0002-0713-447XGiménez-Palop, Olga|||0000-0002-4526-6342Palao, Diego|||0000-0002-3323-6568Pamias, Montserrat|||0000-0003-1114-5419Labad, Javier|||0000-0003-2214-1886AdolescentAttention Deficit Disorder with HyperactivityBiomarkersChildChild AbuseCognitionFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemProlactinSalivaOur study aimed to explore whether stress-related hormones (hypothalamic-pituitary-adrenal [HPA] axis hormones and prolactin) are associated with poorer cognitive functioning in adolescents with attention deficit and hyperactivity disorder (ADHD) and to test the potential moderating effect of childhood maltreatment. Seventy-six adolescents with ADHD were studied. The ADHD rating scale (ADHD-RS) and Childhood Trauma Questionnaire (CTQ) were administered. Seven cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were administered, and two cognitive factors (attention and memory as well as executive functioning) were identified by confirmatory factor analysis. Stress-related hormone levels were assessed at the clinic (plasma prolactin and cortisol levels and salivary cortisol levels) before cognitive testing and at home for two consecutive days (cortisol awakening response [CAR] and diurnal cortisol slope). Multiple linear regression analyses were used to explore the association between hormone levels and ADHD severity or cognitive functioning while adjusting for sex and childhood maltreatment. Regarding hormonal measurements obtained at the clinic, female sex moderated the relationship between salivary cortisol levels and executive functioning, whereas childhood maltreatment moderated the relationship between salivary cortisol levels and inattention symptoms of patients with ADHD. Prolactin levels were not associated with cognitive functioning or the severity of ADHD. Regarding HPA axis measurements performed at home, lower cortisol levels at awakening were associated with poorer executive functioning. Neither CAR nor the cortisol diurnal slope were associated with cognitive functioning or ADHD severity. Our study suggests that HPA axis hormone levels are associated with the severity of cognitive and inattention symptoms of patients with ADHD and that childhood maltreatment and sex exert distinct moderating effects depending on the symptom type. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/291033https://dx.doi.org/urn:doi:10.1016/j.jpsychires.2022.02.041reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2910332026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Stress-related biomarkers and cognitive functioning in adolescents with ADHD Effect of childhood maltreatment |
| title |
Stress-related biomarkers and cognitive functioning in adolescents with ADHD |
| spellingShingle |
Stress-related biomarkers and cognitive functioning in adolescents with ADHD Llorens, Marta|||0000-0001-8532-0115 Adolescent Attention Deficit Disorder with Hyperactivity Biomarkers Child Child Abuse Cognition Female Humans Hydrocortisone Hypothalamo-Hypophyseal System Pituitary-Adrenal System Prolactin Saliva |
| title_short |
Stress-related biomarkers and cognitive functioning in adolescents with ADHD |
| title_full |
Stress-related biomarkers and cognitive functioning in adolescents with ADHD |
| title_fullStr |
Stress-related biomarkers and cognitive functioning in adolescents with ADHD |
| title_full_unstemmed |
Stress-related biomarkers and cognitive functioning in adolescents with ADHD |
| title_sort |
Stress-related biomarkers and cognitive functioning in adolescents with ADHD |
| dc.creator.none.fl_str_mv |
Llorens, Marta|||0000-0001-8532-0115 Barba, Maria Torralbas Ortega, Jordi|||0000-0002-9423-9332 Nadal i Alemany, Roser|||0000-0001-8972-2525 Armario Garcia, Antonio|||0000-0001-9524-3635 Gagliano, Humberto Antonio|||0000-0001-8727-9080 Betriu, Maria Urraca Camps, Lara|||0000-0002-7800-0874 Pujol, Susana Montalvo Aguirrezabala, Itziar|||0000-0002-7320-5109 Gracia Liso, Rebeca|||0000-0002-0713-447X Giménez-Palop, Olga|||0000-0002-4526-6342 Palao, Diego|||0000-0002-3323-6568 Pamias, Montserrat|||0000-0003-1114-5419 Labad, Javier|||0000-0003-2214-1886 |
| author |
Llorens, Marta|||0000-0001-8532-0115 |
| author_facet |
Llorens, Marta|||0000-0001-8532-0115 Barba, Maria Torralbas Ortega, Jordi|||0000-0002-9423-9332 Nadal i Alemany, Roser|||0000-0001-8972-2525 Armario Garcia, Antonio|||0000-0001-9524-3635 Gagliano, Humberto Antonio|||0000-0001-8727-9080 Betriu, Maria Urraca Camps, Lara|||0000-0002-7800-0874 Pujol, Susana Montalvo Aguirrezabala, Itziar|||0000-0002-7320-5109 Gracia Liso, Rebeca|||0000-0002-0713-447X Giménez-Palop, Olga|||0000-0002-4526-6342 Palao, Diego|||0000-0002-3323-6568 Pamias, Montserrat|||0000-0003-1114-5419 Labad, Javier|||0000-0003-2214-1886 |
| author_role |
author |
| author2 |
Barba, Maria Torralbas Ortega, Jordi|||0000-0002-9423-9332 Nadal i Alemany, Roser|||0000-0001-8972-2525 Armario Garcia, Antonio|||0000-0001-9524-3635 Gagliano, Humberto Antonio|||0000-0001-8727-9080 Betriu, Maria Urraca Camps, Lara|||0000-0002-7800-0874 Pujol, Susana Montalvo Aguirrezabala, Itziar|||0000-0002-7320-5109 Gracia Liso, Rebeca|||0000-0002-0713-447X Giménez-Palop, Olga|||0000-0002-4526-6342 Palao, Diego|||0000-0002-3323-6568 Pamias, Montserrat|||0000-0003-1114-5419 Labad, Javier|||0000-0003-2214-1886 |
| author2_role |
author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Adolescent Attention Deficit Disorder with Hyperactivity Biomarkers Child Child Abuse Cognition Female Humans Hydrocortisone Hypothalamo-Hypophyseal System Pituitary-Adrenal System Prolactin Saliva |
| topic |
Adolescent Attention Deficit Disorder with Hyperactivity Biomarkers Child Child Abuse Cognition Female Humans Hydrocortisone Hypothalamo-Hypophyseal System Pituitary-Adrenal System Prolactin Saliva |
| description |
Our study aimed to explore whether stress-related hormones (hypothalamic-pituitary-adrenal [HPA] axis hormones and prolactin) are associated with poorer cognitive functioning in adolescents with attention deficit and hyperactivity disorder (ADHD) and to test the potential moderating effect of childhood maltreatment. Seventy-six adolescents with ADHD were studied. The ADHD rating scale (ADHD-RS) and Childhood Trauma Questionnaire (CTQ) were administered. Seven cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were administered, and two cognitive factors (attention and memory as well as executive functioning) were identified by confirmatory factor analysis. Stress-related hormone levels were assessed at the clinic (plasma prolactin and cortisol levels and salivary cortisol levels) before cognitive testing and at home for two consecutive days (cortisol awakening response [CAR] and diurnal cortisol slope). Multiple linear regression analyses were used to explore the association between hormone levels and ADHD severity or cognitive functioning while adjusting for sex and childhood maltreatment. Regarding hormonal measurements obtained at the clinic, female sex moderated the relationship between salivary cortisol levels and executive functioning, whereas childhood maltreatment moderated the relationship between salivary cortisol levels and inattention symptoms of patients with ADHD. Prolactin levels were not associated with cognitive functioning or the severity of ADHD. Regarding HPA axis measurements performed at home, lower cortisol levels at awakening were associated with poorer executive functioning. Neither CAR nor the cortisol diurnal slope were associated with cognitive functioning or ADHD severity. Our study suggests that HPA axis hormone levels are associated with the severity of cognitive and inattention symptoms of patients with ADHD and that childhood maltreatment and sex exert distinct moderating effects depending on the symptom type. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 AM http://purl.org/coar/version/c_ab4af688f83e57aa |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/291033 https://dx.doi.org/urn:doi:10.1016/j.jpsychires.2022.02.041 |
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https://ddd.uab.cat/record/291033 https://dx.doi.org/urn:doi:10.1016/j.jpsychires.2022.02.041 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://rightsstatements.org/vocab/InC/1.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://rightsstatements.org/vocab/InC/1.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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