Exposome and basal cell carcinoma
Background: While ultraviolet radiation (UVR) present in sunlight is recognized as the main etiological agent of skin cancer, the most frequent form of which is basal cell carcinoma (BCC), other exposome factors like pollution, diet, and lifestyle may also contribute. This study aimed to investigate...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:304060 |
| Acesso em linha: | https://ddd.uab.cat/record/304060 https://dx.doi.org/urn:doi:10.1111/ijd.17026 |
| Access Level: | acceso abierto |
| Palavra-chave: | Adult Aged Carcinoma, Basal Cell Case-Control Studies Diet Exposome Female Humans Life Style Male Middle Aged Occupational Exposure Prospective Studies Risk Factors Skin Neoplasms Spain Sunlight Sunscreening Agents Ultraviolet Rays |
| id |
ES_72b83c5dddb0ca3d2ac20e0e7889d9b9 |
|---|---|
| oai_identifier_str |
oai:ddd.uab.cat:304060 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Exposome and basal cell carcinomaa multicenter case-control studyNavarro-Bielsa, Alba|||0000-0003-1171-6007Gracia-Cazaña, T.Almagro, M.De-la-Fuente-Meira, S.Florez, Á.Yélamos, Oriol|||0000-0002-8058-3095Montero-Vilchez, Trinidad|||0000-0003-4035-7955González-Cruz, C.|||0000-0003-0117-8858Diago, A.Abadías-Granado, IsabelFuentelsaz, V.Colmenero, M.Bañuls, J.Arias-Santiago, Salvador|||0000-0002-4186-1435Buendía-Eisman, A.Almenara-Blasco, Manuel|||0000-0002-4350-401XGil-Pallares, Pedro|||0000-0001-8469-1942Gilaberte, Y.AdultAgedCarcinoma, Basal CellCase-Control StudiesDietExposomeFemaleHumansLife StyleMaleMiddle AgedOccupational ExposureProspective StudiesRisk FactorsSkin NeoplasmsSpainSunlightSunscreening AgentsUltraviolet RaysBackground: While ultraviolet radiation (UVR) present in sunlight is recognized as the main etiological agent of skin cancer, the most frequent form of which is basal cell carcinoma (BCC), other exposome factors like pollution, diet, and lifestyle may also contribute. This study aimed to investigate the association of BCC and exposome-related factors in the Spanish population. Methods: BCC cases (n = 119) and controls (n = 127) with no history of skin cancer were recruited between April 2020 and August 2022 by 13 dermatologists throughout Spain in this prospective multicenter case-control study. Results: The BCC group had a higher proportion of outdoor workers, more years of UVR exposure, and a greater consumption of drugs (statins, ASA, hydrochlorothiazide, ACE inhibitors and omeprazole), P < 0.05. Avoidance of sun exposure was the most used photoprotection measure in both groups. The use of hats or caps was higher in the BCC group (P = 0.01). The solar protection factor (SPF) used 15 years previously was higher in the control group (P = 0.04). The control group had a higher daily screen time (P < 0.001), and practiced more relaxation activities (P = 0.03). Higher linolenic acid intake and lower coffee consumption were the only dietary variables associated with BCC (P < 0.05). Statistical significance for all the aforementioned variables was maintained in the multivariate analysis (P < 0.05). Conclusions: The study found a significant association between BCC and multiple exposome-related factors in addition to chronic sun exposure in the Spanish population. Primary prevention strategies should target specific populations, such as outdoor workers, promoting sun-safe behaviors and stress-reducing activities, and also adequate skin photoprotection in patients on certain medications associated with increased BCC risk. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/304060https://dx.doi.org/urn:doi:10.1111/ijd.17026reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3040602026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Exposome and basal cell carcinoma a multicenter case-control study |
| title |
Exposome and basal cell carcinoma |
| spellingShingle |
Exposome and basal cell carcinoma Navarro-Bielsa, Alba|||0000-0003-1171-6007 Adult Aged Carcinoma, Basal Cell Case-Control Studies Diet Exposome Female Humans Life Style Male Middle Aged Occupational Exposure Prospective Studies Risk Factors Skin Neoplasms Spain Sunlight Sunscreening Agents Ultraviolet Rays |
| title_short |
Exposome and basal cell carcinoma |
| title_full |
Exposome and basal cell carcinoma |
| title_fullStr |
Exposome and basal cell carcinoma |
| title_full_unstemmed |
Exposome and basal cell carcinoma |
| title_sort |
Exposome and basal cell carcinoma |
| dc.creator.none.fl_str_mv |
Navarro-Bielsa, Alba|||0000-0003-1171-6007 Gracia-Cazaña, T. Almagro, M. De-la-Fuente-Meira, S. Florez, Á. Yélamos, Oriol|||0000-0002-8058-3095 Montero-Vilchez, Trinidad|||0000-0003-4035-7955 González-Cruz, C.|||0000-0003-0117-8858 Diago, A. Abadías-Granado, Isabel Fuentelsaz, V. Colmenero, M. Bañuls, J. Arias-Santiago, Salvador|||0000-0002-4186-1435 Buendía-Eisman, A. Almenara-Blasco, Manuel|||0000-0002-4350-401X Gil-Pallares, Pedro|||0000-0001-8469-1942 Gilaberte, Y. |
| author |
Navarro-Bielsa, Alba|||0000-0003-1171-6007 |
| author_facet |
Navarro-Bielsa, Alba|||0000-0003-1171-6007 Gracia-Cazaña, T. Almagro, M. De-la-Fuente-Meira, S. Florez, Á. Yélamos, Oriol|||0000-0002-8058-3095 Montero-Vilchez, Trinidad|||0000-0003-4035-7955 González-Cruz, C.|||0000-0003-0117-8858 Diago, A. Abadías-Granado, Isabel Fuentelsaz, V. Colmenero, M. Bañuls, J. Arias-Santiago, Salvador|||0000-0002-4186-1435 Buendía-Eisman, A. Almenara-Blasco, Manuel|||0000-0002-4350-401X Gil-Pallares, Pedro|||0000-0001-8469-1942 Gilaberte, Y. |
| author_role |
author |
| author2 |
Gracia-Cazaña, T. Almagro, M. De-la-Fuente-Meira, S. Florez, Á. Yélamos, Oriol|||0000-0002-8058-3095 Montero-Vilchez, Trinidad|||0000-0003-4035-7955 González-Cruz, C.|||0000-0003-0117-8858 Diago, A. Abadías-Granado, Isabel Fuentelsaz, V. Colmenero, M. Bañuls, J. Arias-Santiago, Salvador|||0000-0002-4186-1435 Buendía-Eisman, A. Almenara-Blasco, Manuel|||0000-0002-4350-401X Gil-Pallares, Pedro|||0000-0001-8469-1942 Gilaberte, Y. |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Adult Aged Carcinoma, Basal Cell Case-Control Studies Diet Exposome Female Humans Life Style Male Middle Aged Occupational Exposure Prospective Studies Risk Factors Skin Neoplasms Spain Sunlight Sunscreening Agents Ultraviolet Rays |
| topic |
Adult Aged Carcinoma, Basal Cell Case-Control Studies Diet Exposome Female Humans Life Style Male Middle Aged Occupational Exposure Prospective Studies Risk Factors Skin Neoplasms Spain Sunlight Sunscreening Agents Ultraviolet Rays |
| description |
Background: While ultraviolet radiation (UVR) present in sunlight is recognized as the main etiological agent of skin cancer, the most frequent form of which is basal cell carcinoma (BCC), other exposome factors like pollution, diet, and lifestyle may also contribute. This study aimed to investigate the association of BCC and exposome-related factors in the Spanish population. Methods: BCC cases (n = 119) and controls (n = 127) with no history of skin cancer were recruited between April 2020 and August 2022 by 13 dermatologists throughout Spain in this prospective multicenter case-control study. Results: The BCC group had a higher proportion of outdoor workers, more years of UVR exposure, and a greater consumption of drugs (statins, ASA, hydrochlorothiazide, ACE inhibitors and omeprazole), P < 0.05. Avoidance of sun exposure was the most used photoprotection measure in both groups. The use of hats or caps was higher in the BCC group (P = 0.01). The solar protection factor (SPF) used 15 years previously was higher in the control group (P = 0.04). The control group had a higher daily screen time (P < 0.001), and practiced more relaxation activities (P = 0.03). Higher linolenic acid intake and lower coffee consumption were the only dietary variables associated with BCC (P < 0.05). Statistical significance for all the aforementioned variables was maintained in the multivariate analysis (P < 0.05). Conclusions: The study found a significant association between BCC and multiple exposome-related factors in addition to chronic sun exposure in the Spanish population. Primary prevention strategies should target specific populations, such as outdoor workers, promoting sun-safe behaviors and stress-reducing activities, and also adequate skin photoprotection in patients on certain medications associated with increased BCC risk. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/304060 https://dx.doi.org/urn:doi:10.1111/ijd.17026 |
| url |
https://ddd.uab.cat/record/304060 https://dx.doi.org/urn:doi:10.1111/ijd.17026 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
| instname_str |
Universitat Autònoma de Barcelona |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
| collection |
Dipòsit Digital de Documents de la UAB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869410756472078336 |
| score |
15,812455 |