Therapeutic Drug Monitoring of Vancomycin Concentrations for the Management of Bone and Joint Infections

Vancomycin is used for the treatment of bone and joint infections (BJI), but scarce information is available about its pharmacokinetic/pharmacodynamic (PK/PD) characteristics. We aimed to identify the risk factors associated with the non-achievement of an optimal PK/PD target in the first therapeuti...

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Bibliographic Details
Authors: Rio-No, Laura, Sorlí, Luisa|||0000-0001-9562-514X, Arderiu-Formentí, Alba, de Antonio Ferrer, Marta|||0000-0002-4319-797X, Martorell, Lucas, Subirana, Isaac|||0000-0003-1676-0197, Puig-Verdié, Lluís|||0000-0002-4432-9452, Alier, Albert, Gómez-Junyent, Joan|||0000-0003-1752-1382, Pérez-Prieto, Daniel|||0000-0002-7112-0742, Luque, Sonia|||0000-0002-3215-320X
Format: article
Publication Date:2023
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:272888
Online Access:https://ddd.uab.cat/record/272888
https://dx.doi.org/urn:doi:10.3390/tropicalmed8020113
Access Level:Open access
Keyword:Bone and joint infections
Vancomycin
Therapeutic drug monitoring
Pharmacokinetics
Nephrotoxicity
Dosage regimens
Description
Summary:Vancomycin is used for the treatment of bone and joint infections (BJI), but scarce information is available about its pharmacokinetic/pharmacodynamic (PK/PD) characteristics. We aimed to identify the risk factors associated with the non-achievement of an optimal PK/PD target in the first therapeutic drug monitoring (TDM). Methods: A retrospective study was conducted in a tertiary hospital from January 2020 to January 2022. Patients with BJI and TDM of vancomycin on day 2 of treatment were included. Initial vancomycin fixed doses (1 g every 8 h or 12 h) was decided by the responsible doctors. According to TDM results, dosage adjustments were performed. An AUC/MIC < 400 mg × h/L, between 400 and 600 mg × h/L and.

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