Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets

Objective: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets...

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Detalhes bibliográficos
Autores: Postema, Merel C., Vilarroya, Óscar, Francks, Clyde
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/48014
Acesso em linha:http://hdl.handle.net/10230/48014
http://dx.doi.org/10.1111/jcpp.13396
Access Level:acceso abierto
Palavra-chave:Attention-deficit
Brain asymmetry
Brain laterality
Hyperactivity disorder
Large-scale data
Structural MRI
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spelling Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasetsPostema, Merel C.Vilarroya, ÓscarFrancks, ClydeAttention-deficitBrain asymmetryBrain lateralityHyperactivity disorderLarge-scale dataStructural MRIObjective: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. Methods: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries. Results: There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing. Conclusion: Prior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.Wiley202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/48014http://dx.doi.org/10.1111/jcpp.13396reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJ Child Psychol Psychiatry. 2021;62(10):1202-19info:eu-repo/grantAgreement/EC/H2020/728018info:eu-repo/grantAgreement/EC/H2020/643051info:eu-repo/grantAgreement/ES/3PN/SAF2012-32362info:eu-repo/grantAgreement/EC/FP7/278948info:eu-repo/grantAgreement/EC/H2020/847818© 2021 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/480142026-05-29T05:05:01Z
dc.title.none.fl_str_mv Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets
title Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets
spellingShingle Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets
Postema, Merel C.
Attention-deficit
Brain asymmetry
Brain laterality
Hyperactivity disorder
Large-scale data
Structural MRI
title_short Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets
title_full Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets
title_fullStr Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets
title_full_unstemmed Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets
title_sort Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets
dc.creator.none.fl_str_mv Postema, Merel C.
Vilarroya, Óscar
Francks, Clyde
author Postema, Merel C.
author_facet Postema, Merel C.
Vilarroya, Óscar
Francks, Clyde
author_role author
author2 Vilarroya, Óscar
Francks, Clyde
author2_role author
author
dc.subject.none.fl_str_mv Attention-deficit
Brain asymmetry
Brain laterality
Hyperactivity disorder
Large-scale data
Structural MRI
topic Attention-deficit
Brain asymmetry
Brain laterality
Hyperactivity disorder
Large-scale data
Structural MRI
description Objective: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. Methods: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries. Results: There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing. Conclusion: Prior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/48014
http://dx.doi.org/10.1111/jcpp.13396
url http://hdl.handle.net/10230/48014
http://dx.doi.org/10.1111/jcpp.13396
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv J Child Psychol Psychiatry. 2021;62(10):1202-19
info:eu-repo/grantAgreement/EC/H2020/728018
info:eu-repo/grantAgreement/EC/H2020/643051
info:eu-repo/grantAgreement/ES/3PN/SAF2012-32362
info:eu-repo/grantAgreement/EC/FP7/278948
info:eu-repo/grantAgreement/EC/H2020/847818
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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