Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea

Serednytskyy, Oleksandr; Alonso-Fernandez, Alberto; Ribot Quetglas, Caterina; Herranz Mochales, Andrea; Álvarez Valdivielso, Ainhoa; Sanchez, andres; Rodriguez, Paula; Gil, Ana V.; Pia, Carla; Cubero Marin, Jose Pablo; Barcelo, Maria; Cerda Moncadas, Maria; Codina Marcet, Mercedes; D. Pena, Monica; Barceló Bennasar, Antonia; Iglesias, Amanda; Morell-Garcia, Daniel; Peña-Zarza, José Antonio; Gimenez, Maria P.; Pinas, Maria C.; Garcia-Rio, Francisco

Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea

Background Although some evidence suggests an association between obstructive sleep apnea (OSA) and gestational diabetes mellitus (GDM), its consequences still remain largely unknown. We sought to determine whether OSA is associated with higher inflammation and sympathetic levels in GDM, and to rela...

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Detalhes bibliográficos
Autores:	Serednytskyy, Oleksandr, Alonso-Fernandez, Alberto, Ribot Quetglas, Caterina, Herranz Mochales, Andrea, Álvarez Valdivielso, Ainhoa, Sanchez, andres, Rodriguez, Paula, Gil, Ana V., Pia, Carla, Cubero Marin, Jose Pablo, Barcelo, Maria, Cerda Moncadas, Maria, Codina Marcet, Mercedes, D. Pena, Monica, Barceló Bennasar, Antonia, Iglesias, Amanda, Morell-Garcia, Daniel, Peña-Zarza, José Antonio, Gimenez, Maria P., Pinas, Maria C., Garcia-Rio, Francisco
Tipo de documento:	artigo
Data de publicação:	2022
País:	España
Recursos:	Conselleria de Salut i Consum del Govern de les Illes Balears
Repositório:	Docusalut
Idioma:	inglês
OAI Identifier:	oai:docusalut.com:20.500.13003/19842
Acesso em linha:	https://hdl.handle.net/20.500.13003/19842
Access Level:	Acceso aberto
Palavra-chave:	Pregnancy Polysomnography Infant, Newborn Female Sleep Apnea, Obstructive Humans Inflammation Diabetes, Gestational Insulin Resistance Diabetes Gestacional Apnea Obstructiva del Sueño Humanos Inflamación Embarazo Recién Nacido Femenino Resistencia a la Insulina Polisomnografía Gestational diabetes mellitus Fetal outcomes Cytokine inflammation Metanephrine Normetanephrine Obstructive sleep apnea

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spelling	Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apneaSerednytskyy, OleksandrAlonso-Fernandez, AlbertoRibot Quetglas, CaterinaHerranz Mochales, AndreaÁlvarez Valdivielso, AinhoaSanchez, andresRodriguez, PaulaGil, Ana V.Pia, CarlaCubero Marin, Jose PabloBarcelo, MariaCerda Moncadas, MariaCodina Marcet, MercedesD. Pena, MonicaBarceló Bennasar, AntoniaIglesias, AmandaMorell-Garcia, DanielPeña-Zarza, José AntonioGimenez, Maria P.Pinas, Maria C.Garcia-Rio, FranciscoPregnancyPolysomnographyInfant, NewbornFemaleSleep Apnea, ObstructiveHumansInflammationDiabetes, GestationalInsulin ResistanceDiabetes GestacionalApnea Obstructiva del SueñoHumanosInflamaciónEmbarazoRecién NacidoFemeninoResistencia a la InsulinaPolisomnografíaGestational diabetes mellitusFetal outcomesCytokineinflammationMetanephrineNormetanephrineObstructive sleep apneaBackground Although some evidence suggests an association between obstructive sleep apnea (OSA) and gestational diabetes mellitus (GDM), its consequences still remain largely unknown. We sought to determine whether OSA is associated with higher inflammation and sympathetic levels in GDM, and to relate them with insulin resistance and perinatal outcomes. Methods OSA was identified by polysomnography and defined as an apnea-hypopnea index of >= 5 h(-1). Plasma cytokines (TNF-alpha, IL-1 beta, IL-6, IL-8, IL-10), metanephrine, and normetanephrine were determined by immunoassays. Results We included 17 patients with GDM and OSA and 34 without OSA. Women with GDM and OSA had higher normetanephrine concentrations [81 IQR (59-134) vs. 68 (51-81) pg/mL]. No differences in the inflammatory profile were found, while IL-1 beta was higher in patients with mean nocturnal oxyhemoglobin saturation <= 94%. We found positive correlations between increased sympathetic activation and IL-1 beta, with obstructive apneas, while time in REM showed an inverse relationship with IL-1 beta and metanephrine. Furthermore, IL-10 was inversely related with time in sleep stages 1-2, and with the arousal index, and it was positively related with time in slow-wave sleep. Significant correlations were also found between IL-1 beta and insulin resistance. There were no significant differences in neonatal characteristics; however, we found inverse relationships between IL-10 and birth weight (BW), and percentile of BW. Conclusions OSA increased sympathetic activity, and IL-1 beta concentration was higher in patients with GDM with lower nocturnal oxygenation, all of which were related with obstructive events, and time in REM. Moreover, IL-1 beta was related with insulin resistance, and IL-10 inversely correlated with neonatal BW.BMC20222022-03-1820222022-03-18research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/19842reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/198422026-06-22T12:44:07Z
dc.title.none.fl_str_mv	Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea
title	Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea
spellingShingle	Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea Serednytskyy, Oleksandr Pregnancy Polysomnography Infant, Newborn Female Sleep Apnea, Obstructive Humans Inflammation Diabetes, Gestational Insulin Resistance Diabetes Gestacional Apnea Obstructiva del Sueño Humanos Inflamación Embarazo Recién Nacido Femenino Resistencia a la Insulina Polisomnografía Gestational diabetes mellitus Fetal outcomes Cytokine inflammation Metanephrine Normetanephrine Obstructive sleep apnea
title_short	Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea
title_full	Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea
title_fullStr	Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea
title_full_unstemmed	Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea
title_sort	Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea
dc.creator.none.fl_str_mv	Serednytskyy, Oleksandr Alonso-Fernandez, Alberto Ribot Quetglas, Caterina Herranz Mochales, Andrea Álvarez Valdivielso, Ainhoa Sanchez, andres Rodriguez, Paula Gil, Ana V. Pia, Carla Cubero Marin, Jose Pablo Barcelo, Maria Cerda Moncadas, Maria Codina Marcet, Mercedes D. Pena, Monica Barceló Bennasar, Antonia Iglesias, Amanda Morell-Garcia, Daniel Peña-Zarza, José Antonio Gimenez, Maria P. Pinas, Maria C. Garcia-Rio, Francisco
author	Serednytskyy, Oleksandr
author_facet	Serednytskyy, Oleksandr Alonso-Fernandez, Alberto Ribot Quetglas, Caterina Herranz Mochales, Andrea Álvarez Valdivielso, Ainhoa Sanchez, andres Rodriguez, Paula Gil, Ana V. Pia, Carla Cubero Marin, Jose Pablo Barcelo, Maria Cerda Moncadas, Maria Codina Marcet, Mercedes D. Pena, Monica Barceló Bennasar, Antonia Iglesias, Amanda Morell-Garcia, Daniel Peña-Zarza, José Antonio Gimenez, Maria P. Pinas, Maria C. Garcia-Rio, Francisco
author_role	author
author2	Alonso-Fernandez, Alberto Ribot Quetglas, Caterina Herranz Mochales, Andrea Álvarez Valdivielso, Ainhoa Sanchez, andres Rodriguez, Paula Gil, Ana V. Pia, Carla Cubero Marin, Jose Pablo Barcelo, Maria Cerda Moncadas, Maria Codina Marcet, Mercedes D. Pena, Monica Barceló Bennasar, Antonia Iglesias, Amanda Morell-Garcia, Daniel Peña-Zarza, José Antonio Gimenez, Maria P. Pinas, Maria C. Garcia-Rio, Francisco
author2_role	author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Pregnancy Polysomnography Infant, Newborn Female Sleep Apnea, Obstructive Humans Inflammation Diabetes, Gestational Insulin Resistance Diabetes Gestacional Apnea Obstructiva del Sueño Humanos Inflamación Embarazo Recién Nacido Femenino Resistencia a la Insulina Polisomnografía Gestational diabetes mellitus Fetal outcomes Cytokine inflammation Metanephrine Normetanephrine Obstructive sleep apnea
topic	Pregnancy Polysomnography Infant, Newborn Female Sleep Apnea, Obstructive Humans Inflammation Diabetes, Gestational Insulin Resistance Diabetes Gestacional Apnea Obstructiva del Sueño Humanos Inflamación Embarazo Recién Nacido Femenino Resistencia a la Insulina Polisomnografía Gestational diabetes mellitus Fetal outcomes Cytokine inflammation Metanephrine Normetanephrine Obstructive sleep apnea
description	Background Although some evidence suggests an association between obstructive sleep apnea (OSA) and gestational diabetes mellitus (GDM), its consequences still remain largely unknown. We sought to determine whether OSA is associated with higher inflammation and sympathetic levels in GDM, and to relate them with insulin resistance and perinatal outcomes. Methods OSA was identified by polysomnography and defined as an apnea-hypopnea index of >= 5 h(-1). Plasma cytokines (TNF-alpha, IL-1 beta, IL-6, IL-8, IL-10), metanephrine, and normetanephrine were determined by immunoassays. Results We included 17 patients with GDM and OSA and 34 without OSA. Women with GDM and OSA had higher normetanephrine concentrations [81 IQR (59-134) vs. 68 (51-81) pg/mL]. No differences in the inflammatory profile were found, while IL-1 beta was higher in patients with mean nocturnal oxyhemoglobin saturation <= 94%. We found positive correlations between increased sympathetic activation and IL-1 beta, with obstructive apneas, while time in REM showed an inverse relationship with IL-1 beta and metanephrine. Furthermore, IL-10 was inversely related with time in sleep stages 1-2, and with the arousal index, and it was positively related with time in slow-wave sleep. Significant correlations were also found between IL-1 beta and insulin resistance. There were no significant differences in neonatal characteristics; however, we found inverse relationships between IL-10 and birth weight (BW), and percentile of BW. Conclusions OSA increased sympathetic activity, and IL-1 beta concentration was higher in patients with GDM with lower nocturnal oxygenation, all of which were related with obstructive events, and time in REM. Moreover, IL-1 beta was related with insulin resistance, and IL-10 inversely correlated with neonatal BW.
publishDate	2022
dc.date.none.fl_str_mv	2022 2022-03-18 2022 2022-03-18
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.13003/19842
url	https://hdl.handle.net/20.500.13003/19842
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	BMC
publisher.none.fl_str_mv	BMC
dc.source.none.fl_str_mv	reponame:Docusalut instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str	Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str	Docusalut
collection	Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea

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