In vitro investigation on the antiglycative and carbonyl trapping activities of hydroxytyrosol

10 páginas, 5 figuras, 1 tabla

Bibliographic Details
Authors: Navarro, Marta, Morales, F. J.
Format: article
Status:Versión aceptada para publicación
Publication Date:2016
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/138126
Online Access:http://hdl.handle.net/10261/138126
Access Level:Open access
Keyword:Hydroxytyrosol
Antiglycative activity
Advanced glycation end products
Carboxymethyl-lysine
Carboxyethyl-lysine
Argpyrimidine
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spelling In vitro investigation on the antiglycative and carbonyl trapping activities of hydroxytyrosolNavarro, MartaMorales, F. J.HydroxytyrosolAntiglycative activityAdvanced glycation end productsCarboxymethyl-lysineCarboxyethyl-lysineArgpyrimidine10 páginas, 5 figuras, 1 tablaAdvanced glycation end products (AGEs) are involved in the aging and the development of common chronic diseases. Hydroxytyrosol (HT) and its acetate derivative (HTA) exert a significant inhibitory activity on the formation of fluorescent AGEs in bovine serum albumin glycation model systems induced by methylglyoxal (IC50 value of 0.48 and 0.58 µmol/mL, respectively) and glucose (IC50 2.30 and 2.92 µmol/mL, respectively). Furthermore, HT and HTA showed a relevant carbonyl scavenging capacity toward methylglyoxal and glyoxal, which are the most potent promoters of the glycation in vivo, at molar reaction rates from 0.2 to 10 (carbonyl:phenol). However, carbonyl trapping capacity was significantly more effective against methylglyoxal (IC50 0.19 µmol/mL) than glyoxal (IC50 0.26 µmol/mL). At equimolar concentrations, the ester linkage did not significantly affect the antiglycative activity and carbonyl trapping capacity of the orthodiphenolic ring structure. Results were confirmed with the specific inhibition of the formation of the principal AGEs. Formation of carboxymethyl-lysine, argpyrimidine and carboxyethyl-lysine was significantly reduced by 61.9, 71.4 and 20.9 %, respectively. HT and its esters could be considered for upscaling studies as promising natural strategy against adverse consequences of protein glycation.This work was funded by Projects S2013/ABI-3028-AVANSECAL from Comunidad of Madrid and European funding from FEDER program (European Regional Development Fund) and CSIC-201370E027 (Spanish National Research Council).Peer reviewedSpringer NatureComunidad de MadridConsejo Superior de Investigaciones Científicas (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201620162016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/138126reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1381262026-05-22T06:33:51Z
dc.title.none.fl_str_mv In vitro investigation on the antiglycative and carbonyl trapping activities of hydroxytyrosol
title In vitro investigation on the antiglycative and carbonyl trapping activities of hydroxytyrosol
spellingShingle In vitro investigation on the antiglycative and carbonyl trapping activities of hydroxytyrosol
Navarro, Marta
Hydroxytyrosol
Antiglycative activity
Advanced glycation end products
Carboxymethyl-lysine
Carboxyethyl-lysine
Argpyrimidine
title_short In vitro investigation on the antiglycative and carbonyl trapping activities of hydroxytyrosol
title_full In vitro investigation on the antiglycative and carbonyl trapping activities of hydroxytyrosol
title_fullStr In vitro investigation on the antiglycative and carbonyl trapping activities of hydroxytyrosol
title_full_unstemmed In vitro investigation on the antiglycative and carbonyl trapping activities of hydroxytyrosol
title_sort In vitro investigation on the antiglycative and carbonyl trapping activities of hydroxytyrosol
dc.creator.none.fl_str_mv Navarro, Marta
Morales, F. J.
author Navarro, Marta
author_facet Navarro, Marta
Morales, F. J.
author_role author
author2 Morales, F. J.
author2_role author
dc.contributor.none.fl_str_mv Comunidad de Madrid
Consejo Superior de Investigaciones Científicas (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Hydroxytyrosol
Antiglycative activity
Advanced glycation end products
Carboxymethyl-lysine
Carboxyethyl-lysine
Argpyrimidine
topic Hydroxytyrosol
Antiglycative activity
Advanced glycation end products
Carboxymethyl-lysine
Carboxyethyl-lysine
Argpyrimidine
description 10 páginas, 5 figuras, 1 tabla
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/138126
url http://hdl.handle.net/10261/138126
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410405842944000
score 15,228081

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