Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.

Abstract Amphetamine-related drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), are popular recreational psychostimulants. Several preclinical studies have demonstrated that, besides having the potential for abuse, amphetamine-related drugs may also elicit neurotoxic...

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Autores: Moratalla, Rosario, Khairnar, Amit, Simola, Nicola, Granado, Noelia, García-Montes, José Rubén, Porceddu, Pier Francesca, Tizabi, Yousef, Costa, Giulia, Morelli, Micaela
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/156486
Acceso en línea:http://hdl.handle.net/10261/156486
Access Level:acceso abierto
Palabra clave:Rat
Non-human primates
Neuroinflammation neurotoxicity
Neurodegeneration
Mouse
Methamphetamine
3,4-Methylenedioxymethamphetamine
MDMA
Ecstasy
METH
Dopamine
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spelling Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.Moratalla, RosarioKhairnar, AmitSimola, NicolaGranado, NoeliaGarcía-Montes, José RubénPorceddu, Pier FrancescaTizabi, YousefCosta, GiuliaMorelli, MicaelaRatNon-human primatesNeuroinflammation neurotoxicityNeurodegenerationMouseMethamphetamine3,4-MethylenedioxymethamphetamineMDMAEcstasyMETHDopamineAbstract Amphetamine-related drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), are popular recreational psychostimulants. Several preclinical studies have demonstrated that, besides having the potential for abuse, amphetamine-related drugs may also elicit neurotoxic and neuroinflammatory effects. The neurotoxic potentials of MDMA and METH to dopaminergic and serotonergic neurons have been clearly demonstrated in both rodents and non-human primates. This review summarizes the species-specific cellular and molecular mechanisms involved in MDMA and METH-mediated neurotoxic and neuroinflammatory effects, along with the most important behavioral changes elicited by these substances in experimental animals and humans. Emphasis is placed on the neuropsychological and neurological consequences associated with the neuronal damage. Moreover, we point out the gap in our knowledge and the need for developing appropriate therapeutic strategies to manage the neurological problems associated with amphetamine-related drug abuse. Copyright © 2015. Published by Elsevier Ltd.This work was supported by grants from the Spanish Ministerios de Economía y Competitividad (SAF2013-48532-R) and of Sanidad Política Social e Igualdad(PNSD #2012/071, and ISCIII, CIBERNED CB06/05/0055) and Comunidad de Madrid ref. S2011/BMD-2336 to RM and by funds from the Regione Autonoma della Sardegna (Legge Regionale 7 Agosto 2007, N.7, annualità 2008 and 2010) to MM and by funds from to Sardinian Regional Government for financial support (P.O.R. Sardegna F.S.E. Operational Programme of the Autonomous Region of Sardinia, European Social Fund 2007–2013 – Axis IV Human Resources, Objective l.3, Line of Activity l.3.1 “Avviso di chiamata per il finanziamento di Assegni di Ricerca”) to. NS.Peer ReviewedPergamon PressMinisterio de Economía y Competitividad (España)Ministerio de Sanidad y Política Social (España)Instituto de Salud Carlos IIIComunidad de MadridRegione Autonoma della SardegnaEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2017201720152017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/156486reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-48532-RS2011/BMD-2336/NEUROSTEMSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1564862026-05-22T06:33:51Z
dc.title.none.fl_str_mv Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.
title Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.
spellingShingle Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.
Moratalla, Rosario
Rat
Non-human primates
Neuroinflammation neurotoxicity
Neurodegeneration
Mouse
Methamphetamine
3,4-Methylenedioxymethamphetamine
MDMA
Ecstasy
METH
Dopamine
title_short Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.
title_full Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.
title_fullStr Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.
title_full_unstemmed Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.
title_sort Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.
dc.creator.none.fl_str_mv Moratalla, Rosario
Khairnar, Amit
Simola, Nicola
Granado, Noelia
García-Montes, José Rubén
Porceddu, Pier Francesca
Tizabi, Yousef
Costa, Giulia
Morelli, Micaela
author Moratalla, Rosario
author_facet Moratalla, Rosario
Khairnar, Amit
Simola, Nicola
Granado, Noelia
García-Montes, José Rubén
Porceddu, Pier Francesca
Tizabi, Yousef
Costa, Giulia
Morelli, Micaela
author_role author
author2 Khairnar, Amit
Simola, Nicola
Granado, Noelia
García-Montes, José Rubén
Porceddu, Pier Francesca
Tizabi, Yousef
Costa, Giulia
Morelli, Micaela
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Ministerio de Sanidad y Política Social (España)
Instituto de Salud Carlos III
Comunidad de Madrid
Regione Autonoma della Sardegna
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Rat
Non-human primates
Neuroinflammation neurotoxicity
Neurodegeneration
Mouse
Methamphetamine
3,4-Methylenedioxymethamphetamine
MDMA
Ecstasy
METH
Dopamine
topic Rat
Non-human primates
Neuroinflammation neurotoxicity
Neurodegeneration
Mouse
Methamphetamine
3,4-Methylenedioxymethamphetamine
MDMA
Ecstasy
METH
Dopamine
description Abstract Amphetamine-related drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), are popular recreational psychostimulants. Several preclinical studies have demonstrated that, besides having the potential for abuse, amphetamine-related drugs may also elicit neurotoxic and neuroinflammatory effects. The neurotoxic potentials of MDMA and METH to dopaminergic and serotonergic neurons have been clearly demonstrated in both rodents and non-human primates. This review summarizes the species-specific cellular and molecular mechanisms involved in MDMA and METH-mediated neurotoxic and neuroinflammatory effects, along with the most important behavioral changes elicited by these substances in experimental animals and humans. Emphasis is placed on the neuropsychological and neurological consequences associated with the neuronal damage. Moreover, we point out the gap in our knowledge and the need for developing appropriate therapeutic strategies to manage the neurological problems associated with amphetamine-related drug abuse. Copyright © 2015. Published by Elsevier Ltd.
publishDate 2015
dc.date.none.fl_str_mv 2015
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/156486
url http://hdl.handle.net/10261/156486
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-48532-R
S2011/BMD-2336/NEUROSTEM
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Pergamon Press
publisher.none.fl_str_mv Pergamon Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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