A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats

Caprine livestock are significant reservoirs of the Mycobacterium tuberculosis complex (MTBC),contributing to tuberculosis (TB) transmission among animals and humans. The P22 proteinimmunocomplex (P22PI), derived from bovine tuberculin, shows immunostimulating capacityand is used for TB diagnosis. T...

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Authors: Ortega, J., Agulló Ros, I., Roy, A., Moreno, I., Gómez Buendía, Alberto, Romero Martínez, Beatriz, Ferreras Colino, E., Juan Ferré, Lucía De, Domínguez, M., Domínguez Rodríguez, Lucas José, Risalde, M.A., Bezos Garrido, Javier
Format: article
Publication Date:2024
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/113081
Online Access:https://hdl.handle.net/20.500.14352/113081
Access Level:Open access
Keyword:636.09
Tuberculosis
Goat
Immunisation
P22protein immunocomplex
Diagnosis
Lesions
Veterinaria
3109 Ciencias Veterinarias
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oai_identifier_str oai:docta.ucm.es:20.500.14352/113081
network_acronym_str ES
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repository_id_str
spelling A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goatsOrtega, J.Agulló Ros, I.Roy, A.Moreno, I.Gómez Buendía, AlbertoRomero Martínez, BeatrizFerreras Colino, E.Juan Ferré, Lucía DeDomínguez, M.Domínguez Rodríguez, Lucas JoséRisalde, M.A.Bezos Garrido, Javier636.09TuberculosisGoatImmunisationP22protein immunocomplexDiagnosisLesionsVeterinaria3109 Ciencias VeterinariasCaprine livestock are significant reservoirs of the Mycobacterium tuberculosis complex (MTBC),contributing to tuberculosis (TB) transmission among animals and humans. The P22 proteinimmunocomplex (P22PI), derived from bovine tuberculin, shows immunostimulating capacityand is used for TB diagnosis. This study assessed the immunogenicity and protective efficacyof P22PI in two groups of goats: 24 naïve goats (12 immunised, 12 controls) from a TB-freeherd, and 24 infected goats (12 immunised, 12 controls), referred to as pre-infected animals,from a M. bovis-infected herd. Both were exposed for 5 months to M. bovis-naturally infectedgoats. Reactors to single and comparative intradermal tuberculin (SIT and SCIT, respectively)tests and interferon-gamma release assay (IGRA) significantly increased (p < 0.05) in bothgroups 5 months’ post-exposure, with no significant differences between immunised andcontrol animals. However, immunised animals exhibited a significantly higher (p < 0.05)antibody response against P22PI. Most naïve animals (83.3%) and all pre-infected animalsdeveloped TB-compatible lesions, with extensive necrosis in the lungs and associated lymphnodes, compared to 50% and 83.3% of control animals, respectively. These findings suggestthat while P22PI stimulates an intense antibody response under the conditions of the presentstudy, it does not confer protection against TB and may exacerbate disease severity.Taylor & FrancisUniversidad Complutense de Madrid20242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/113081reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1130812026-06-02T12:44:21Z
dc.title.none.fl_str_mv A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats
title A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats
spellingShingle A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats
Ortega, J.
636.09
Tuberculosis
Goat
Immunisation
P22protein immunocomplex
Diagnosis
Lesions
Veterinaria
3109 Ciencias Veterinarias
title_short A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats
title_full A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats
title_fullStr A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats
title_full_unstemmed A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats
title_sort A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats
dc.creator.none.fl_str_mv Ortega, J.
Agulló Ros, I.
Roy, A.
Moreno, I.
Gómez Buendía, Alberto
Romero Martínez, Beatriz
Ferreras Colino, E.
Juan Ferré, Lucía De
Domínguez, M.
Domínguez Rodríguez, Lucas José
Risalde, M.A.
Bezos Garrido, Javier
author Ortega, J.
author_facet Ortega, J.
Agulló Ros, I.
Roy, A.
Moreno, I.
Gómez Buendía, Alberto
Romero Martínez, Beatriz
Ferreras Colino, E.
Juan Ferré, Lucía De
Domínguez, M.
Domínguez Rodríguez, Lucas José
Risalde, M.A.
Bezos Garrido, Javier
author_role author
author2 Agulló Ros, I.
Roy, A.
Moreno, I.
Gómez Buendía, Alberto
Romero Martínez, Beatriz
Ferreras Colino, E.
Juan Ferré, Lucía De
Domínguez, M.
Domínguez Rodríguez, Lucas José
Risalde, M.A.
Bezos Garrido, Javier
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 636.09
Tuberculosis
Goat
Immunisation
P22protein immunocomplex
Diagnosis
Lesions
Veterinaria
3109 Ciencias Veterinarias
topic 636.09
Tuberculosis
Goat
Immunisation
P22protein immunocomplex
Diagnosis
Lesions
Veterinaria
3109 Ciencias Veterinarias
description Caprine livestock are significant reservoirs of the Mycobacterium tuberculosis complex (MTBC),contributing to tuberculosis (TB) transmission among animals and humans. The P22 proteinimmunocomplex (P22PI), derived from bovine tuberculin, shows immunostimulating capacityand is used for TB diagnosis. This study assessed the immunogenicity and protective efficacyof P22PI in two groups of goats: 24 naïve goats (12 immunised, 12 controls) from a TB-freeherd, and 24 infected goats (12 immunised, 12 controls), referred to as pre-infected animals,from a M. bovis-infected herd. Both were exposed for 5 months to M. bovis-naturally infectedgoats. Reactors to single and comparative intradermal tuberculin (SIT and SCIT, respectively)tests and interferon-gamma release assay (IGRA) significantly increased (p < 0.05) in bothgroups 5 months’ post-exposure, with no significant differences between immunised andcontrol animals. However, immunised animals exhibited a significantly higher (p < 0.05)antibody response against P22PI. Most naïve animals (83.3%) and all pre-infected animalsdeveloped TB-compatible lesions, with extensive necrosis in the lungs and associated lymphnodes, compared to 50% and 83.3% of control animals, respectively. These findings suggestthat while P22PI stimulates an intense antibody response under the conditions of the presentstudy, it does not confer protection against TB and may exacerbate disease severity.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/113081
url https://hdl.handle.net/20.500.14352/113081
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410275640213504
score 15.812455

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