Should We Treat SIBO Patients? Impact on Quality of Life and Response to Comprehensive Treatment: A Real-World Clinical Practice Study.

Background: Small intestinal bacterial overgrowth (SIBO) is a dysbiosis marked by an excessive proliferation of bacteria in the small intestine, resulting in abdominal symptoms that significantly affect patients' quality of life. Objectives: This study aims to evaluate the impact of a comprehen...

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Autores: Liébana-Castillo AR, Redondo-Cuevas L, Nicolás Á, Martín-Carbonell V, Sanchis L, Olivares A, Grau F, Ynfante M, Colmenares M, Molina ML, Lorente JR, Tomás H, Moreno N, Garayoa A, Jaén M, Mora M, Gonzalvo J, Molés JR, Díaz S, Sancho N, Sánchez E, Ortiz J, Gil-Guillén V, Cortés-Castell E, Cortés-Rizo X
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositório:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p18608
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/18608
Access Level:Acceso aberto
Palavra-chave:FODMAP diet
Small Intestine Bacterial Overgrowth (SIBO)
antibiotics
gut microbiota
herbal therapies
probiotics
quality of life
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spelling Should We Treat SIBO Patients? Impact on Quality of Life and Response to Comprehensive Treatment: A Real-World Clinical Practice Study.Liébana-Castillo ARRedondo-Cuevas LNicolás ÁMartín-Carbonell VSanchis LOlivares AGrau FYnfante MColmenares MMolina MLLorente JRTomás HMoreno NGarayoa AJaén MMora MGonzalvo JMolés JRDíaz SSancho NSánchez EOrtiz JGil-Guillén VCortés-Castell ECortés-Rizo XFODMAP dietSmall Intestine Bacterial Overgrowth (SIBO)antibioticsgut microbiotaherbal therapiesprobioticsquality of lifeBackground: Small intestinal bacterial overgrowth (SIBO) is a dysbiosis marked by an excessive proliferation of bacteria in the small intestine, resulting in abdominal symptoms that significantly affect patients' quality of life. Objectives: This study aims to evaluate the impact of a comprehensive therapeutic approach in improving the quality of life of patients with SIBO. Methods: For this purpose, standardized questionnaires were used at baseline, 30 days and 90 days, including the IBS-QOL (Irritable Bowel Syndrome Quality of Life Questionnaire), the GSRS (Gastrointestinal Symptom Rating Scale), the EuroQOL-5D, and the Bristol Scale. Results: The results show that a comprehensive approach, combining pharmacological treatment, appropriate dietary intervention, and strategies aimed at improving gut microbiota and intestinal permeability, produces a sustained improvement in the quality of life of a significant proportion of patients who participated in the study. Furthermore, the results suggest that, although gas normalization is a relevant indicator, clinical improvement and quality of life depend considerably on patients' subjective perception of their health. Conclusions: This finding underscores the importance of recognizing SIBO as a prevalent condition that requires accurate diagnoses and individualized treatments to improve patients' well-being.MDPI2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/18608NutrientsISSN: 20726643reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p186082026-06-11T12:45:17Z
dc.title.none.fl_str_mv Should We Treat SIBO Patients? Impact on Quality of Life and Response to Comprehensive Treatment: A Real-World Clinical Practice Study.
title Should We Treat SIBO Patients? Impact on Quality of Life and Response to Comprehensive Treatment: A Real-World Clinical Practice Study.
spellingShingle Should We Treat SIBO Patients? Impact on Quality of Life and Response to Comprehensive Treatment: A Real-World Clinical Practice Study.
Liébana-Castillo AR
FODMAP diet
Small Intestine Bacterial Overgrowth (SIBO)
antibiotics
gut microbiota
herbal therapies
probiotics
quality of life
title_short Should We Treat SIBO Patients? Impact on Quality of Life and Response to Comprehensive Treatment: A Real-World Clinical Practice Study.
title_full Should We Treat SIBO Patients? Impact on Quality of Life and Response to Comprehensive Treatment: A Real-World Clinical Practice Study.
title_fullStr Should We Treat SIBO Patients? Impact on Quality of Life and Response to Comprehensive Treatment: A Real-World Clinical Practice Study.
title_full_unstemmed Should We Treat SIBO Patients? Impact on Quality of Life and Response to Comprehensive Treatment: A Real-World Clinical Practice Study.
title_sort Should We Treat SIBO Patients? Impact on Quality of Life and Response to Comprehensive Treatment: A Real-World Clinical Practice Study.
dc.creator.none.fl_str_mv Liébana-Castillo AR
Redondo-Cuevas L
Nicolás Á
Martín-Carbonell V
Sanchis L
Olivares A
Grau F
Ynfante M
Colmenares M
Molina ML
Lorente JR
Tomás H
Moreno N
Garayoa A
Jaén M
Mora M
Gonzalvo J
Molés JR
Díaz S
Sancho N
Sánchez E
Ortiz J
Gil-Guillén V
Cortés-Castell E
Cortés-Rizo X
author Liébana-Castillo AR
author_facet Liébana-Castillo AR
Redondo-Cuevas L
Nicolás Á
Martín-Carbonell V
Sanchis L
Olivares A
Grau F
Ynfante M
Colmenares M
Molina ML
Lorente JR
Tomás H
Moreno N
Garayoa A
Jaén M
Mora M
Gonzalvo J
Molés JR
Díaz S
Sancho N
Sánchez E
Ortiz J
Gil-Guillén V
Cortés-Castell E
Cortés-Rizo X
author_role author
author2 Redondo-Cuevas L
Nicolás Á
Martín-Carbonell V
Sanchis L
Olivares A
Grau F
Ynfante M
Colmenares M
Molina ML
Lorente JR
Tomás H
Moreno N
Garayoa A
Jaén M
Mora M
Gonzalvo J
Molés JR
Díaz S
Sancho N
Sánchez E
Ortiz J
Gil-Guillén V
Cortés-Castell E
Cortés-Rizo X
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FODMAP diet
Small Intestine Bacterial Overgrowth (SIBO)
antibiotics
gut microbiota
herbal therapies
probiotics
quality of life
topic FODMAP diet
Small Intestine Bacterial Overgrowth (SIBO)
antibiotics
gut microbiota
herbal therapies
probiotics
quality of life
description Background: Small intestinal bacterial overgrowth (SIBO) is a dysbiosis marked by an excessive proliferation of bacteria in the small intestine, resulting in abdominal symptoms that significantly affect patients' quality of life. Objectives: This study aims to evaluate the impact of a comprehensive therapeutic approach in improving the quality of life of patients with SIBO. Methods: For this purpose, standardized questionnaires were used at baseline, 30 days and 90 days, including the IBS-QOL (Irritable Bowel Syndrome Quality of Life Questionnaire), the GSRS (Gastrointestinal Symptom Rating Scale), the EuroQOL-5D, and the Bristol Scale. Results: The results show that a comprehensive approach, combining pharmacological treatment, appropriate dietary intervention, and strategies aimed at improving gut microbiota and intestinal permeability, produces a sustained improvement in the quality of life of a significant proportion of patients who participated in the study. Furthermore, the results suggest that, although gas normalization is a relevant indicator, clinical improvement and quality of life depend considerably on patients' subjective perception of their health. Conclusions: This finding underscores the importance of recognizing SIBO as a prevalent condition that requires accurate diagnoses and individualized treatments to improve patients' well-being.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/18608
url https://fisabio.portalinvestigacion.com/publicaciones/18608
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Nutrients
ISSN: 20726643
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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