Critical Study on the Tube-to-Chip Luer Slip Connectors.

Luer slip is one of the gold standards for chip-to-world interface in microfluidics. They have outstanding mechanical and operational robustness in a broad range of applications using water and solvent-based liquids. Still, their main drawbacks are related to their size: they have relatively large d...

ver descrição completa

Detalhes bibliográficos
Autores: Etxeberria, Leire, Aguilera, Unai, García de Madinabeitia, Pablo, Sáez, Alberto, Zaldua Huici, Ane Miren, Vilas Vilela, José Luis, Fernández, Luis, Llobera, Andreu
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/57728
Acesso em linha:http://hdl.handle.net/10810/57728
Access Level:acceso abierto
Palavra-chave:LoC devices
Luer slip connectors
microfluidic connectors
tube-to-chip connection
useful life
id ES_69c2d30cd7aaac5802495d3a77970d28
oai_identifier_str oai:addi.ehu.eus:10810/57728
network_acronym_str ES
network_name_str España
repository_id_str
spelling Critical Study on the Tube-to-Chip Luer Slip Connectors.Etxeberria, LeireAguilera, UnaiGarcía de Madinabeitia, PabloSáez, AlbertoZaldua Huici, Ane MirenVilas Vilela, José LuisFernández, LuisLlobera, AndreuLoC devicesLuer slip connectorsmicrofluidic connectorstube-to-chip connectionuseful lifeLuer slip is one of the gold standards for chip-to-world interface in microfluidics. They have outstanding mechanical and operational robustness in a broad range of applications using water and solvent-based liquids. Still, their main drawbacks are related to their size: they have relatively large dead volumes and require a significant footprint to assure a leak-free performance. Such aspects make their integration in systems with high microchannel density challenging. To date, there has been no geometrical optimization of the Luer slips to provide a solution to the mentioned drawbacks. This work aims to provide the rules toward downscaling the Luer slips. To this effect, seven variations of the Luer slip male connectors and five variations of Luer slip female connectors have been designed and manufactured focusing on the reduction of the size of connectors and minimization of the dead volumes. In all cases, female connectors have been developed to pair with the corresponding male connector. Characterization has been performed with a tailor-made test bench in which the closure force between male and female connectors has been varied between 7.9 and 55 N. For each applied closure force, the test bench allows liquid pressures to be tested between 0.5 and 2.0 bar. Finally, the analysis of a useful life determines the number of cycles that the connectors can withstand before leakage.The authors are grateful for the financial support from the Basque Country Government within the frame of the project BIKAINTEK 2018 (48-AF-W2-2018-00006).Frontiers Media202220222022info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/57728reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.frontiersin.org/articles/10.3389/fmedt.2022.881930/fullinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© 2022 Etxeberria, Aguilera, Garcia de Madinabeitia, Saez, Zaldua, Vilas- Vilela, Fernández and Llobera. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Atribución 3.0 Españaoai:addi.ehu.eus:10810/577282026-06-18T09:23:17Z
dc.title.none.fl_str_mv Critical Study on the Tube-to-Chip Luer Slip Connectors.
title Critical Study on the Tube-to-Chip Luer Slip Connectors.
spellingShingle Critical Study on the Tube-to-Chip Luer Slip Connectors.
Etxeberria, Leire
LoC devices
Luer slip connectors
microfluidic connectors
tube-to-chip connection
useful life
title_short Critical Study on the Tube-to-Chip Luer Slip Connectors.
title_full Critical Study on the Tube-to-Chip Luer Slip Connectors.
title_fullStr Critical Study on the Tube-to-Chip Luer Slip Connectors.
title_full_unstemmed Critical Study on the Tube-to-Chip Luer Slip Connectors.
title_sort Critical Study on the Tube-to-Chip Luer Slip Connectors.
dc.creator.none.fl_str_mv Etxeberria, Leire
Aguilera, Unai
García de Madinabeitia, Pablo
Sáez, Alberto
Zaldua Huici, Ane Miren
Vilas Vilela, José Luis
Fernández, Luis
Llobera, Andreu
author Etxeberria, Leire
author_facet Etxeberria, Leire
Aguilera, Unai
García de Madinabeitia, Pablo
Sáez, Alberto
Zaldua Huici, Ane Miren
Vilas Vilela, José Luis
Fernández, Luis
Llobera, Andreu
author_role author
author2 Aguilera, Unai
García de Madinabeitia, Pablo
Sáez, Alberto
Zaldua Huici, Ane Miren
Vilas Vilela, José Luis
Fernández, Luis
Llobera, Andreu
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv LoC devices
Luer slip connectors
microfluidic connectors
tube-to-chip connection
useful life
topic LoC devices
Luer slip connectors
microfluidic connectors
tube-to-chip connection
useful life
description Luer slip is one of the gold standards for chip-to-world interface in microfluidics. They have outstanding mechanical and operational robustness in a broad range of applications using water and solvent-based liquids. Still, their main drawbacks are related to their size: they have relatively large dead volumes and require a significant footprint to assure a leak-free performance. Such aspects make their integration in systems with high microchannel density challenging. To date, there has been no geometrical optimization of the Luer slips to provide a solution to the mentioned drawbacks. This work aims to provide the rules toward downscaling the Luer slips. To this effect, seven variations of the Luer slip male connectors and five variations of Luer slip female connectors have been designed and manufactured focusing on the reduction of the size of connectors and minimization of the dead volumes. In all cases, female connectors have been developed to pair with the corresponding male connector. Characterization has been performed with a tailor-made test bench in which the closure force between male and female connectors has been varied between 7.9 and 55 N. For each applied closure force, the test bench allows liquid pressures to be tested between 0.5 and 2.0 bar. Finally, the analysis of a useful life determines the number of cycles that the connectors can withstand before leakage.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/57728
url http://hdl.handle.net/10810/57728
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.frontiersin.org/articles/10.3389/fmedt.2022.881930/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410053033820160
score 15.198674

Registos relacionados