Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals

Delayed recall (DR) impairment is one of the most significant predictive factors in defining the progression to Alzheimer’s disease (AD). Changes in brain functional connectivity (FC) could accompany this decline in the DR performance even in a resting state condition from the preclinical stages to...

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Autores: Chino, Brenda, Cuesta Prieto, Pablo, Pacios García, Javier, De Frutos Lucas, Jaisalmer, Torres Simón, Lucía, Doval Moreno, Sandra, Marcos Dolado, Alberto, Bruña Fernández, Ricardo, Maestu Unturbe, Fernando
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/100676
Acceso en línea:https://hdl.handle.net/20.500.14352/100676
Access Level:acceso abierto
Palabra clave:612.8
Delayed recall
MCI
Cognitively normal
Functional connectivity
MEG
Neurociencias (Medicina)
2490 Neurociencias
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oai_identifier_str oai:docta.ucm.es:20.500.14352/100676
network_acronym_str ES
network_name_str España
repository_id_str
spelling Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individualsChino, BrendaCuesta Prieto, PabloPacios García, JavierDe Frutos Lucas, JaisalmerTorres Simón, LucíaDoval Moreno, SandraMarcos Dolado, AlbertoBruña Fernández, RicardoMaestu Unturbe, Fernando612.8Delayed recallMCICognitively normalFunctional connectivityMEGNeurociencias (Medicina)2490 NeurocienciasDelayed recall (DR) impairment is one of the most significant predictive factors in defining the progression to Alzheimer’s disease (AD). Changes in brain functional connectivity (FC) could accompany this decline in the DR performance even in a resting state condition from the preclinical stages to the diagnosis of AD itself, so the characterization of the relationship between the two phenomena has attracted increasing interest. Another aspect to contemplate is the potential moderator role of the APOE genotype in this association, considering the evidence about their implication for the disease. 379 subjects (118 mild cognitive impairment (MCI) and 261 cognitively intact (CI) individuals) underwent an extensive evaluation, including MEG recording. Applying cluster-based permutation test, we identified a cluster of differences in FC and studied which connections drove such an effect in DR. The moderation effect of APOE genotype between FC results and delayed recall was evaluated too. Higher FC in beta band in the right occipital region is associated with lower DR scores in both groups. A significant anteroposterior link emerged in the seed-based analysis with higher values in MCI. Moreover, APOE genotype appeared as a moderator between beta FC and DR performance only in the CI group. An increased beta FC in the anteroposterior brain region appears to be associated with lower memory performance in MCI. This finding could help discriminate the pattern of the progression of healthy aging to MCI and the relation between resting state and memory performance.SpringerUniversidad Complutense de Madrid20222022-09-1520222022-09-15journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/100676reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1006762026-06-02T12:44:21Z
dc.title.none.fl_str_mv Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals
title Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals
spellingShingle Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals
Chino, Brenda
612.8
Delayed recall
MCI
Cognitively normal
Functional connectivity
MEG
Neurociencias (Medicina)
2490 Neurociencias
title_short Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals
title_full Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals
title_fullStr Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals
title_full_unstemmed Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals
title_sort Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals
dc.creator.none.fl_str_mv Chino, Brenda
Cuesta Prieto, Pablo
Pacios García, Javier
De Frutos Lucas, Jaisalmer
Torres Simón, Lucía
Doval Moreno, Sandra
Marcos Dolado, Alberto
Bruña Fernández, Ricardo
Maestu Unturbe, Fernando
author Chino, Brenda
author_facet Chino, Brenda
Cuesta Prieto, Pablo
Pacios García, Javier
De Frutos Lucas, Jaisalmer
Torres Simón, Lucía
Doval Moreno, Sandra
Marcos Dolado, Alberto
Bruña Fernández, Ricardo
Maestu Unturbe, Fernando
author_role author
author2 Cuesta Prieto, Pablo
Pacios García, Javier
De Frutos Lucas, Jaisalmer
Torres Simón, Lucía
Doval Moreno, Sandra
Marcos Dolado, Alberto
Bruña Fernández, Ricardo
Maestu Unturbe, Fernando
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 612.8
Delayed recall
MCI
Cognitively normal
Functional connectivity
MEG
Neurociencias (Medicina)
2490 Neurociencias
topic 612.8
Delayed recall
MCI
Cognitively normal
Functional connectivity
MEG
Neurociencias (Medicina)
2490 Neurociencias
description Delayed recall (DR) impairment is one of the most significant predictive factors in defining the progression to Alzheimer’s disease (AD). Changes in brain functional connectivity (FC) could accompany this decline in the DR performance even in a resting state condition from the preclinical stages to the diagnosis of AD itself, so the characterization of the relationship between the two phenomena has attracted increasing interest. Another aspect to contemplate is the potential moderator role of the APOE genotype in this association, considering the evidence about their implication for the disease. 379 subjects (118 mild cognitive impairment (MCI) and 261 cognitively intact (CI) individuals) underwent an extensive evaluation, including MEG recording. Applying cluster-based permutation test, we identified a cluster of differences in FC and studied which connections drove such an effect in DR. The moderation effect of APOE genotype between FC results and delayed recall was evaluated too. Higher FC in beta band in the right occipital region is associated with lower DR scores in both groups. A significant anteroposterior link emerged in the seed-based analysis with higher values in MCI. Moreover, APOE genotype appeared as a moderator between beta FC and DR performance only in the CI group. An increased beta FC in the anteroposterior brain region appears to be associated with lower memory performance in MCI. This finding could help discriminate the pattern of the progression of healthy aging to MCI and the relation between resting state and memory performance.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-09-15
2022
2022-09-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/100676
url https://hdl.handle.net/20.500.14352/100676
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,223283

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