The Fungicide Ipconazole Can Activate Mediators of Cellular Damage in Rat Brain Regions

This study aimed to investigate the toxicity of the fungicide ipconazole on oxidative status, cell death and inflammasome complex activation in the hypothalamus, cerebral cortex, striatum and hippocampus of rats. Female albino rats were randomly divided into a control group and four groups treated w...

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Detalles Bibliográficos
Autores: Villaorduña, Carlos, Barrios Arpi, Luis, Lira Mejía, Boris, Ramos González, Mariella, Ramos Coaguilla, Olger, Inostroza Ruiz, Luis, Romero Martínez, Manuel Alejandro, Rodríguez, José Luis
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/108717
Acceso en línea:https://hdl.handle.net/20.500.14352/108717
Access Level:acceso abierto
Palabra clave:636.09:615.9
Neurotoxicity
Ipconazole
Rat brain regions
Oxidative stress
Cell death
Inflammasome
Veterinaria
Toxicología (Farmacia)
3109 Ciencias Veterinarias
3214 Toxicología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/108717
network_acronym_str ES
network_name_str España
repository_id_str
spelling The Fungicide Ipconazole Can Activate Mediators of Cellular Damage in Rat Brain RegionsVillaorduña, CarlosBarrios Arpi, LuisLira Mejía, BorisRamos González, MariellaRamos Coaguilla, OlgerInostroza Ruiz, LuisRomero Martínez, Manuel AlejandroRodríguez, José Luis636.09:615.9NeurotoxicityIpconazoleRat brain regionsOxidative stressCell deathInflammasomeVeterinariaToxicología (Farmacia)3109 Ciencias Veterinarias3214 ToxicologíaThis study aimed to investigate the toxicity of the fungicide ipconazole on oxidative status, cell death and inflammasome complex activation in the hypothalamus, cerebral cortex, striatum and hippocampus of rats. Female albino rats were randomly divided into a control group and four groups treated with ipconazole at doses of 1, 5, 10 and 20 mg/kg b.w., administered for six days. Ipconazole significantly increased MDA and ROS levels in all brain regions studied, while reducing catalase enzyme activity. The molecular expression of cell death-related genes (AKT1, APAF1, BNIP3, CASP3 and BAX) and the inflammasome complex (CASP1, IL1β, IL6, NLRP3, NFĸB and TNFα) was also assessed, showing increased expression in at least one brain region. The findings demonstrate that ipconazole induces central nervous system toxicity in mammals, highlighting its potential role as a risk factor in the development of neurodegenerative disorders in individuals exposed to this contaminant.MDPIUniversidad Complutense de Madrid20242024-08-0120242024-08-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/108717reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1087172026-06-02T12:44:21Z
dc.title.none.fl_str_mv The Fungicide Ipconazole Can Activate Mediators of Cellular Damage in Rat Brain Regions
title The Fungicide Ipconazole Can Activate Mediators of Cellular Damage in Rat Brain Regions
spellingShingle The Fungicide Ipconazole Can Activate Mediators of Cellular Damage in Rat Brain Regions
Villaorduña, Carlos
636.09:615.9
Neurotoxicity
Ipconazole
Rat brain regions
Oxidative stress
Cell death
Inflammasome
Veterinaria
Toxicología (Farmacia)
3109 Ciencias Veterinarias
3214 Toxicología
title_short The Fungicide Ipconazole Can Activate Mediators of Cellular Damage in Rat Brain Regions
title_full The Fungicide Ipconazole Can Activate Mediators of Cellular Damage in Rat Brain Regions
title_fullStr The Fungicide Ipconazole Can Activate Mediators of Cellular Damage in Rat Brain Regions
title_full_unstemmed The Fungicide Ipconazole Can Activate Mediators of Cellular Damage in Rat Brain Regions
title_sort The Fungicide Ipconazole Can Activate Mediators of Cellular Damage in Rat Brain Regions
dc.creator.none.fl_str_mv Villaorduña, Carlos
Barrios Arpi, Luis
Lira Mejía, Boris
Ramos González, Mariella
Ramos Coaguilla, Olger
Inostroza Ruiz, Luis
Romero Martínez, Manuel Alejandro
Rodríguez, José Luis
author Villaorduña, Carlos
author_facet Villaorduña, Carlos
Barrios Arpi, Luis
Lira Mejía, Boris
Ramos González, Mariella
Ramos Coaguilla, Olger
Inostroza Ruiz, Luis
Romero Martínez, Manuel Alejandro
Rodríguez, José Luis
author_role author
author2 Barrios Arpi, Luis
Lira Mejía, Boris
Ramos González, Mariella
Ramos Coaguilla, Olger
Inostroza Ruiz, Luis
Romero Martínez, Manuel Alejandro
Rodríguez, José Luis
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 636.09:615.9
Neurotoxicity
Ipconazole
Rat brain regions
Oxidative stress
Cell death
Inflammasome
Veterinaria
Toxicología (Farmacia)
3109 Ciencias Veterinarias
3214 Toxicología
topic 636.09:615.9
Neurotoxicity
Ipconazole
Rat brain regions
Oxidative stress
Cell death
Inflammasome
Veterinaria
Toxicología (Farmacia)
3109 Ciencias Veterinarias
3214 Toxicología
description This study aimed to investigate the toxicity of the fungicide ipconazole on oxidative status, cell death and inflammasome complex activation in the hypothalamus, cerebral cortex, striatum and hippocampus of rats. Female albino rats were randomly divided into a control group and four groups treated with ipconazole at doses of 1, 5, 10 and 20 mg/kg b.w., administered for six days. Ipconazole significantly increased MDA and ROS levels in all brain regions studied, while reducing catalase enzyme activity. The molecular expression of cell death-related genes (AKT1, APAF1, BNIP3, CASP3 and BAX) and the inflammasome complex (CASP1, IL1β, IL6, NLRP3, NFĸB and TNFα) was also assessed, showing increased expression in at least one brain region. The findings demonstrate that ipconazole induces central nervous system toxicity in mammals, highlighting its potential role as a risk factor in the development of neurodegenerative disorders in individuals exposed to this contaminant.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-08-01
2024
2024-08-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/108717
url https://hdl.handle.net/20.500.14352/108717
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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