Changes in fluoroquinolone-resistant Streptococcus pneumoniae after 7-valent conjugate vaccination, Spain

Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4-8 microg/mL)...

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Detalhes bibliográficos
Autores: de la Campa, Adela G, Ardanuy, Carmen, Balsalobre-Arenas, Maria Luz, Pérez-Trallero, Emilio, Marimón, José María, Fenoll, Asuncion, Liñares, Josefina
Tipo de documento: artigo
Data de publicação:2009
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositório:Repisalud
Idioma:inglês
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/7068
Acesso em linha:http://hdl.handle.net/20.500.12105/7068
Access Level:Acceso aberto
Palavra-chave:Adult
Anti-Bacterial Agents
Bacterial Proteins
Child
Child, Preschool
Ciprofloxacin
Drug Resistance, Bacterial
Electrophoresis, Gel, Pulsed-Field
Fluoroquinolones
Genotype
Heptavalent Pneumococcal Conjugate Vaccine
Humans
Microbial Sensitivity Tests
Mutation
Pneumococcal Vaccines
Prevalence
Sequence Analysis, DNA
Serotyping
Spain
Streptococcal Infections
Streptococcus pneumoniae
Transformation, Bacterial
Vaccination
Descrição
Resumo:Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4-8 microg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV (parC [n = 24] or parE [n = 1]) changes. One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC >or=16 microg/mL) was caused by changes in gyrase (gyrA) and parC or parE. New changes in parC (S80P) and gyrA (S81V, E85G) were shown to be involved in resistance by genetic transformation. Although 49 genotypes were observed, clones Spain9V-ST156 and Sweden15A-ST63 accounted for 34.7% of drug-resistant isolates. In comparison with findings from the 2002 study, clones Spain14-ST17, Spain23F-ST81, and ST8819F decreased and 4 new genotypes (ST9710A, ST57016, ST43322, and ST71733) appeared in 2006.

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