'Monster... -omics': on segmentation, re-segmentation, and vertebrae formation in amphibians and other vertebrates

Background: The axial skeleton is one of the defining evolutionary landmarks of vertebrates. How this structure develops and how it has evolved in the different vertebrate lineages is, however, a matter of debate. Vertebrae and vertebral structures are derived from the embryonic somites, although th...

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Autores: Buckley, David, Molnár, Viktor, Németh, Gábor, Petneházy, Örs, Vörös, Judit
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2013
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/75159
Acesso em linha:http://hdl.handle.net/10261/75159
Access Level:Acceso aberto
Palavra-chave:Development
Evo-devo
Morphology
Osteology
Vertebrae
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spelling 'Monster... -omics': on segmentation, re-segmentation, and vertebrae formation in amphibians and other vertebratesBuckley, DavidMolnár, ViktorNémeth, GáborPetneházy, ÖrsVörös, JuditDevelopmentEvo-devoMorphologyOsteologyVertebraeBackground: The axial skeleton is one of the defining evolutionary landmarks of vertebrates. How this structure develops and how it has evolved in the different vertebrate lineages is, however, a matter of debate. Vertebrae and vertebral structures are derived from the embryonic somites, although the mechanisms of development are different between lineages. Discussion: Using the anecdotal description of a teratological newt (Triturus dobrogicus) with an unusual malformation in its axial skeleton, we review, compare, and discuss the development of vertebral structures and, in particular, the development of centra from somitic cellular domains in different vertebrate groups. Vertebrae development through re-segmentation of the somitic sclerotomal cells is considered the general mechanism among vertebrates, which has been generalized from studies in amniotic model organisms. The prevalence of this mechanism among anamniotes is, however, controversial. We propose alternative developmental mechanisms for vertebrae formation that should be experimentally tested. Summary: Research in model organisms, especially amniotes, is laying the foundations for a thorough understanding of the mechanisms of development of the axial skeleton in vertebrates, foundations that should expand the extent of future comparative studies. Although immersed in the ‘-omics’ era, we emphasize the need for an integrative and organismal approach in evolutionary developmental biology for a better understanding of the causal role of development in the evolution of morphological diversity in nature.JV was supported by the NKFP project (Faunagenezis 3B-02304) from the National Office for Research and Technology, Hungary, and the Hungarian Scientific Research Fund (OTKA K84071). DB was partially supported by the National Science Foundation EF-0334939 project (USA) and a JAE-DOC fellowship from the CSIC (Spain) under the program “Junta para la Ampliación de Estudios” co-financed by the European Social Fund (ESF). The authors also thank the Unit of Information Resources for Research (URICI-CSIC) for the co-financing of this publication in Open Access.We also acknowledge institutional support from the Unit of Information Resources for Research at the “Consejo Superior de Investigaciones Científicas” (CSIC) for the article-processing charges contribution.SIBioMed Central2013201320132013info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/75159reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://www.frontiersinzoology.com/content/10/1/17SIinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/751592026-05-22T06:33:51Z
dc.title.none.fl_str_mv 'Monster... -omics': on segmentation, re-segmentation, and vertebrae formation in amphibians and other vertebrates
title 'Monster... -omics': on segmentation, re-segmentation, and vertebrae formation in amphibians and other vertebrates
spellingShingle 'Monster... -omics': on segmentation, re-segmentation, and vertebrae formation in amphibians and other vertebrates
Buckley, David
Development
Evo-devo
Morphology
Osteology
Vertebrae
title_short 'Monster... -omics': on segmentation, re-segmentation, and vertebrae formation in amphibians and other vertebrates
title_full 'Monster... -omics': on segmentation, re-segmentation, and vertebrae formation in amphibians and other vertebrates
title_fullStr 'Monster... -omics': on segmentation, re-segmentation, and vertebrae formation in amphibians and other vertebrates
title_full_unstemmed 'Monster... -omics': on segmentation, re-segmentation, and vertebrae formation in amphibians and other vertebrates
title_sort 'Monster... -omics': on segmentation, re-segmentation, and vertebrae formation in amphibians and other vertebrates
dc.creator.none.fl_str_mv Buckley, David
Molnár, Viktor
Németh, Gábor
Petneházy, Örs
Vörös, Judit
author Buckley, David
author_facet Buckley, David
Molnár, Viktor
Németh, Gábor
Petneházy, Örs
Vörös, Judit
author_role author
author2 Molnár, Viktor
Németh, Gábor
Petneházy, Örs
Vörös, Judit
author2_role author
author
author
author
dc.subject.none.fl_str_mv Development
Evo-devo
Morphology
Osteology
Vertebrae
topic Development
Evo-devo
Morphology
Osteology
Vertebrae
description Background: The axial skeleton is one of the defining evolutionary landmarks of vertebrates. How this structure develops and how it has evolved in the different vertebrate lineages is, however, a matter of debate. Vertebrae and vertebral structures are derived from the embryonic somites, although the mechanisms of development are different between lineages. Discussion: Using the anecdotal description of a teratological newt (Triturus dobrogicus) with an unusual malformation in its axial skeleton, we review, compare, and discuss the development of vertebral structures and, in particular, the development of centra from somitic cellular domains in different vertebrate groups. Vertebrae development through re-segmentation of the somitic sclerotomal cells is considered the general mechanism among vertebrates, which has been generalized from studies in amniotic model organisms. The prevalence of this mechanism among anamniotes is, however, controversial. We propose alternative developmental mechanisms for vertebrae formation that should be experimentally tested. Summary: Research in model organisms, especially amniotes, is laying the foundations for a thorough understanding of the mechanisms of development of the axial skeleton in vertebrates, foundations that should expand the extent of future comparative studies. Although immersed in the ‘-omics’ era, we emphasize the need for an integrative and organismal approach in evolutionary developmental biology for a better understanding of the causal role of development in the evolution of morphological diversity in nature.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013
2013
2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/75159
url http://hdl.handle.net/10261/75159
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://www.frontiersinzoology.com/content/10/1/17
SI
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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