Non-coding Rnas In Saliva: Emerging Biomarkers For Molecular Diagnostics

Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, which are extensively supplied by blood. Therefore, molecules such as proteins, DNA, RNA, etc., present in plasma could be also present in saliva. Many studies have reported that saliva body fluid can...

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Detalles Bibliográficos
Autores: Majem, Blanca, Rigau, Marina, Reventós Puigjaner, Jaume, Wong, David T.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126102
Acceso en línea:https://hdl.handle.net/2445/126102
Access Level:acceso abierto
Palabra clave:Saliva
Marcadors bioquímics
Micro RNAs
Biochemical markers
MicroRNAs
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spelling Non-coding Rnas In Saliva: Emerging Biomarkers For Molecular DiagnosticsMajem, BlancaRigau, MarinaReventós Puigjaner, JaumeWong, David T.SalivaMarcadors bioquímicsMicro RNAsBiochemical markersMicroRNAsSaliva is a complex body fluid that comprises secretions from the major and minor salivary glands, which are extensively supplied by blood. Therefore, molecules such as proteins, DNA, RNA, etc., present in plasma could be also present in saliva. Many studies have reported that saliva body fluid can be useful for discriminating several oral diseases, but also systemic diseases including cancer. Most of these studies revealed messenger RNA (mRNA) and proteomic biomarker signatures rather than specific non-coding RNA (ncRNA) profiles. NcRNAs are emerging as new regulators of diverse biological functions, playing an important role in oncogenesis and tumor progression. Indeed, the small size of these molecules makes them very stable in different body fluids and not as susceptible as mRNAs to degradation by ribonucleases (RNases). Therefore, the development of a non-invasive salivary test, based on ncRNAs profiles, could have a significant applicability to clinical practice, not only by reducing the cost of the health system, but also by benefitting the patient. Here, we summarize the current status and clinical implications of the ncRNAs present in human saliva as a source of biological information.MDPI2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/126102Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/ijms16048676International Journal of Molecular Sciences, 2015, Vol. 16, Issue 4, P. 8676-8698https://doi.org/10.3390/ijms16048676cc by (c) Majem, Blanca et al., 2015http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1261022026-05-27T06:46:51Z
dc.title.none.fl_str_mv Non-coding Rnas In Saliva: Emerging Biomarkers For Molecular Diagnostics
title Non-coding Rnas In Saliva: Emerging Biomarkers For Molecular Diagnostics
spellingShingle Non-coding Rnas In Saliva: Emerging Biomarkers For Molecular Diagnostics
Majem, Blanca
Saliva
Marcadors bioquímics
Micro RNAs
Biochemical markers
MicroRNAs
title_short Non-coding Rnas In Saliva: Emerging Biomarkers For Molecular Diagnostics
title_full Non-coding Rnas In Saliva: Emerging Biomarkers For Molecular Diagnostics
title_fullStr Non-coding Rnas In Saliva: Emerging Biomarkers For Molecular Diagnostics
title_full_unstemmed Non-coding Rnas In Saliva: Emerging Biomarkers For Molecular Diagnostics
title_sort Non-coding Rnas In Saliva: Emerging Biomarkers For Molecular Diagnostics
dc.creator.none.fl_str_mv Majem, Blanca
Rigau, Marina
Reventós Puigjaner, Jaume
Wong, David T.
author Majem, Blanca
author_facet Majem, Blanca
Rigau, Marina
Reventós Puigjaner, Jaume
Wong, David T.
author_role author
author2 Rigau, Marina
Reventós Puigjaner, Jaume
Wong, David T.
author2_role author
author
author
dc.subject.none.fl_str_mv Saliva
Marcadors bioquímics
Micro RNAs
Biochemical markers
MicroRNAs
topic Saliva
Marcadors bioquímics
Micro RNAs
Biochemical markers
MicroRNAs
description Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, which are extensively supplied by blood. Therefore, molecules such as proteins, DNA, RNA, etc., present in plasma could be also present in saliva. Many studies have reported that saliva body fluid can be useful for discriminating several oral diseases, but also systemic diseases including cancer. Most of these studies revealed messenger RNA (mRNA) and proteomic biomarker signatures rather than specific non-coding RNA (ncRNA) profiles. NcRNAs are emerging as new regulators of diverse biological functions, playing an important role in oncogenesis and tumor progression. Indeed, the small size of these molecules makes them very stable in different body fluids and not as susceptible as mRNAs to degradation by ribonucleases (RNases). Therefore, the development of a non-invasive salivary test, based on ncRNAs profiles, could have a significant applicability to clinical practice, not only by reducing the cost of the health system, but also by benefitting the patient. Here, we summarize the current status and clinical implications of the ncRNAs present in human saliva as a source of biological information.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126102
url https://hdl.handle.net/2445/126102
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms16048676
International Journal of Molecular Sciences, 2015, Vol. 16, Issue 4, P. 8676-8698
https://doi.org/10.3390/ijms16048676
dc.rights.none.fl_str_mv cc by (c) Majem, Blanca et al., 2015
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Majem, Blanca et al., 2015
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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