Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain

Background: Evidence associating exposure to water disinfection by-products with reduced birth weight and altered duration of gestation remains inconclusive. Objective: We assessed exposure to trihalomethanes (THMs) during pregnancy through different water uses and evaluated the association with bir...

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Authors: Villanueva Belmonte, Cristina, Gracia Lavedan, Esther, Ibarluzea, Jesús, Marina, Loreto Santa, Ballester Díez, Ferran, Llop, Sabrina, Tardón, Adonina, Fernandez, Mariana F., Freire, Carmen, Goñi, Fernando, Basagaña Flores, Xavier, Kogevinas, Manolis, Grimalt Obrador, Joan, Sunyer Deu, Jordi
Format: article
Status:Published version
Publication Date:2011
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/23358
Online Access:http://hdl.handle.net/10230/23358
http://dx.doi.org/10.1289/ehp.1002425
Access Level:Open access
Keyword:Infeccions respiratòries -- Epidemiologia
Aigua -- Depuració
Fetus -- Creixement
Embaràs -- Aspectes nutricionals
Epidemiologia
Birth weight
Cohort study
Disinfection by-products
Epidemiology
Low birth weight
Newborn
Premature birth
Small for gestational age
Trihalomethanes
Water pollution
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repository_id_str
spelling Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in SpainVillanueva Belmonte, CristinaGracia Lavedan, EstherIbarluzea, JesúsMarina, Loreto SantaBallester Díez, FerranLlop, SabrinaTardón, AdoninaFernandez, Mariana F.Freire, CarmenGoñi, FernandoBasagaña Flores, XavierKogevinas, ManolisGrimalt Obrador, JoanSunyer Deu, JordiInfeccions respiratòries -- EpidemiologiaAigua -- DepuracióFetus -- CreixementEmbaràs -- Aspectes nutricionalsEpidemiologiaBirth weightCohort studyDisinfection by-productsEpidemiologyLow birth weightNewbornPremature birthSmall for gestational ageTrihalomethanesWater pollutionBackground: Evidence associating exposure to water disinfection by-products with reduced birth weight and altered duration of gestation remains inconclusive. Objective: We assessed exposure to trihalomethanes (THMs) during pregnancy through different water uses and evaluated the association with birth weight, small for gestational age (SGA), low birth weight (LBW), and preterm delivery. Methods: Mother–child cohorts set up in five Spanish areas during the years 2000–2008 contributed data on water ingestion, showering, bathing, and swimming in pools. We ascertained residential THM levels during pregnancy periods through ad hoc sampling campaigns (828 measurements) and regulatory data (264 measurements), which were modeled and combined with personal water use and uptake factors to estimate personal uptake. We defined outcomes following standard definitions and included 2,158 newborns in the analysis. Results: Median residential THM ranged from 5.9 μg/L (Valencia) to 114.7 μg/L (Sabadell), and speciation differed across areas. We estimated that 89% of residential chloroform and 96% of brominated THM uptakes were from showering/bathing. The estimated change of birth weight for a 10% increase in residential uptake was –0.45 g (95% confidence interval: –1.36, 0.45 g) for chloroform and 0.16 g (–1.38, 1.70 g) for brominated THMs. Overall, THMs were not associated with SGA, LBW, or preterm delivery. Conclusions: Despite the high THM levels in some areas and the extensive exposure assessment, results suggest that residential THM exposure during pregnancy driven by inhalation and dermal contact routes is not associated with birth weight, SGA, LBW, or preterm delivery in Spain.This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041; from Fondo de Investigación Sanitaria (FIS): FIS-FEDER (Fondo Europeo de Desarrollo Regional) 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, PI080533, FIS-PI041436, FIS-PI06/0867, FIS-PI081151, FIS-S09-PS09/02311); CIBER (AA08_012); Generalitat de Catalunya-CIRIT (1999SGR 00241); Departamento de Sanidad del Gobierno Vasco (BIOEF06/002); Diputación Foral de Gipuzkoa (DFG06/004); Consejería de Salud, Junta de Andalucía (PI-0183/2007); Conselleria de Sanitat Generalitat Valenciana; Fundació Roger Torné; and HI-WATE (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water) project (FP6-2005-FOOD-4B, reg. 036224)National Institute of Environmental Health Sciences (NIEHS)201520152011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/23358http://dx.doi.org/10.1289/ehp.1002425reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEnvironmental Health Perspectives. 2011;119(12):1824-30Reproduced with permission from Environmental Health Perspectivesinfo:eu-repo/semantics/openAccessoai:recercat.cat:10230/233582026-05-29T05:05:01Z
dc.title.none.fl_str_mv Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain
title Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain
spellingShingle Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain
Villanueva Belmonte, Cristina
Infeccions respiratòries -- Epidemiologia
Aigua -- Depuració
Fetus -- Creixement
Embaràs -- Aspectes nutricionals
Epidemiologia
Birth weight
Cohort study
Disinfection by-products
Epidemiology
Low birth weight
Newborn
Premature birth
Small for gestational age
Trihalomethanes
Water pollution
title_short Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain
title_full Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain
title_fullStr Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain
title_full_unstemmed Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain
title_sort Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain
dc.creator.none.fl_str_mv Villanueva Belmonte, Cristina
Gracia Lavedan, Esther
Ibarluzea, Jesús
Marina, Loreto Santa
Ballester Díez, Ferran
Llop, Sabrina
Tardón, Adonina
Fernandez, Mariana F.
Freire, Carmen
Goñi, Fernando
Basagaña Flores, Xavier
Kogevinas, Manolis
Grimalt Obrador, Joan
Sunyer Deu, Jordi
author Villanueva Belmonte, Cristina
author_facet Villanueva Belmonte, Cristina
Gracia Lavedan, Esther
Ibarluzea, Jesús
Marina, Loreto Santa
Ballester Díez, Ferran
Llop, Sabrina
Tardón, Adonina
Fernandez, Mariana F.
Freire, Carmen
Goñi, Fernando
Basagaña Flores, Xavier
Kogevinas, Manolis
Grimalt Obrador, Joan
Sunyer Deu, Jordi
author_role author
author2 Gracia Lavedan, Esther
Ibarluzea, Jesús
Marina, Loreto Santa
Ballester Díez, Ferran
Llop, Sabrina
Tardón, Adonina
Fernandez, Mariana F.
Freire, Carmen
Goñi, Fernando
Basagaña Flores, Xavier
Kogevinas, Manolis
Grimalt Obrador, Joan
Sunyer Deu, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Infeccions respiratòries -- Epidemiologia
Aigua -- Depuració
Fetus -- Creixement
Embaràs -- Aspectes nutricionals
Epidemiologia
Birth weight
Cohort study
Disinfection by-products
Epidemiology
Low birth weight
Newborn
Premature birth
Small for gestational age
Trihalomethanes
Water pollution
topic Infeccions respiratòries -- Epidemiologia
Aigua -- Depuració
Fetus -- Creixement
Embaràs -- Aspectes nutricionals
Epidemiologia
Birth weight
Cohort study
Disinfection by-products
Epidemiology
Low birth weight
Newborn
Premature birth
Small for gestational age
Trihalomethanes
Water pollution
description Background: Evidence associating exposure to water disinfection by-products with reduced birth weight and altered duration of gestation remains inconclusive. Objective: We assessed exposure to trihalomethanes (THMs) during pregnancy through different water uses and evaluated the association with birth weight, small for gestational age (SGA), low birth weight (LBW), and preterm delivery. Methods: Mother–child cohorts set up in five Spanish areas during the years 2000–2008 contributed data on water ingestion, showering, bathing, and swimming in pools. We ascertained residential THM levels during pregnancy periods through ad hoc sampling campaigns (828 measurements) and regulatory data (264 measurements), which were modeled and combined with personal water use and uptake factors to estimate personal uptake. We defined outcomes following standard definitions and included 2,158 newborns in the analysis. Results: Median residential THM ranged from 5.9 μg/L (Valencia) to 114.7 μg/L (Sabadell), and speciation differed across areas. We estimated that 89% of residential chloroform and 96% of brominated THM uptakes were from showering/bathing. The estimated change of birth weight for a 10% increase in residential uptake was –0.45 g (95% confidence interval: –1.36, 0.45 g) for chloroform and 0.16 g (–1.38, 1.70 g) for brominated THMs. Overall, THMs were not associated with SGA, LBW, or preterm delivery. Conclusions: Despite the high THM levels in some areas and the extensive exposure assessment, results suggest that residential THM exposure during pregnancy driven by inhalation and dermal contact routes is not associated with birth weight, SGA, LBW, or preterm delivery in Spain.
publishDate 2011
dc.date.none.fl_str_mv 2011
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/23358
http://dx.doi.org/10.1289/ehp.1002425
url http://hdl.handle.net/10230/23358
http://dx.doi.org/10.1289/ehp.1002425
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environmental Health Perspectives. 2011;119(12):1824-30
dc.rights.none.fl_str_mv Reproduced with permission from Environmental Health Perspectives
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reproduced with permission from Environmental Health Perspectives
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409731230040064
score 15.228081

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