Application of IPSET-Thrombosis in 1366 Patients Prospectively Followed from the Spanish Registry of Essential Thrombocythemia

The International Prognostic Score of thrombosis in Essential Thrombocythemia (IPSET-Thrombosis) and its revised version have been proposed to guide thrombosis prevention strategies. We evaluated both classifications to prognosticate thrombosis in 1366 contemporary essential thrombocythemia (ET) pat...

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Detalhes bibliográficos
Autores: Alvarez-Larrán, A., Cuevas, B., Velez, P., Noya Pereira, María Soledad, Caballero-Navarro, G., Ferrer-Marín, F., Carbonell, S., Pérez Encinas, Manuel Mateo, Gómez-Casares, M.T., Pérez-López, R., Magro, E., Moretó, A., Pastor-Galán, I., Angona, A., Mata-Vázquez, M.I., Guerrero-Fernández, L., Guerra, J.M., Carreño-Tarragona, G., Fox, L., Murillo, I., García-Gutiérrez, V., Mora, E., Stuckey, R., Arellano-Rodrigo, E., Hernández-Boluda, J.C., Pereira, A.
Tipo de documento: artigo
Data de publicação:2023
País:España
Recursos:Servizo Galego de Saúde (SERGAS)
Repositório:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21094
Acesso em linha:https://portalcientifico.sergas.gal//documentos/64e2a6824a4f093d56e74951
http://hdl.handle.net/20.500.11940/21094
Access Level:Acceso aberto
Palavra-chave:AS A Coruña
CHUAC
AS Santiago
CHUS
Descrição
Resumo:The International Prognostic Score of thrombosis in Essential Thrombocythemia (IPSET-Thrombosis) and its revised version have been proposed to guide thrombosis prevention strategies. We evaluated both classifications to prognosticate thrombosis in 1366 contemporary essential thrombocythemia (ET) patients prospectively followed from the Spanish Registry of ET. The cumulative incidence of thrombosis at 10 years, taking death as a competing risk, was 11.4%. The risk of thrombosis was significantly higher in the high-risk IPSET-Thrombosis and high-risk revised IPSET-Thrombosis, but no differences were observed among the lower risk categories. Patients allocated in high-risk IPSET-Thrombosis (subdistribution hazard ratios [SHR], 3.7 [95% confidence interval, CI, 1.6-8.7]) and high-risk revised IPSET-Thrombosis (SHR, 3.2 [95% CI, 1.4-7.45]) showed an increased risk of arterial thrombosis, whereas both scoring systems failed to predict venous thrombosis. The incidence rate of thrombosis in intermediate risk revised IPSET-Thrombosis (aged >60 years, JAK2-negative, and no history of thrombosis) was very low regardless of the treatment administered (0.9% and 0% per year with and without cytoreduction, respectively). Dynamic application of the revised IPSET-Thrombosis showed a low rate of thrombosis when patients without history of prior thrombosis switched to a higher risk category after reaching 60 years of age. In conclusion, IPSET-Thrombosis scores are useful for identifying patients at high risk of arterial thrombosis, whereas they fail to predict venous thrombosis. Controlled studies are needed to determine the appropriate treatment of ET patients assigned to the non-high-risk categories.

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