Impact of systemic sclerosis on foot skin hydration: A case-control study

Introduction: Systemic sclerosis (SSc), or scleroderma, is a connective tissue disease characterized by excessive collagen production, leading to microvascular damage, fibrosis, and dysfunction of the skin and internal organs. The skin of the foot, due to its weight-bearing function and exposure to...

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Autores: Gracia Sánchez, Alba, García Cano, Laura, Ramos-Petersen, Laura, Gijon-Nogueron, Gabriel, Zúnica García, Sara, Chicharro-Luna, Esther
Tipo de documento: artigo
Data de publicação:2025
País:España
Recursos:Universidad Miguel Hernández de Elche
Repositório:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/37559
Acesso em linha:https://hdl.handle.net/11000/37559
Access Level:Acceso aberto
Palavra-chave:Systemic sclerosis
Skin hydration
Foot, corneometer
Stratum corneum hydration
Scleroderma
CDU::6 - Ciencias aplicadas::61 - Medicina
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spelling Impact of systemic sclerosis on foot skin hydration: A case-control studyGracia Sánchez, AlbaGarcía Cano, LauraRamos-Petersen, LauraGijon-Nogueron, GabrielZúnica García, SaraChicharro-Luna, EstherSystemic sclerosisSkin hydrationFoot, corneometerStratum corneum hydrationSclerodermaCDU::6 - Ciencias aplicadas::61 - MedicinaIntroduction: Systemic sclerosis (SSc), or scleroderma, is a connective tissue disease characterized by excessive collagen production, leading to microvascular damage, fibrosis, and dysfunction of the skin and internal organs. The skin of the foot, due to its weight-bearing function and exposure to mechanical forces, may undergo alterations, contributing to the development of ulcers and other podiatric complications. However, little is known about foot skin hydration in patients with SSc. This study aims to assess the hydration level of the stratum corneum in the foot skin of patients with SSc. Materials and methods: A case-control study was conducted at the Clinical Rheumatology Unit of the Regional University Hospital of M´alaga (Spain). Participants included 47 patients diagnosed with SSc and 52 age- and sexmatched controls. Hydration measurements were performed at ten points on the foot using the Corneometer 825® device. Sociodemographic and clinical data, including smoking habits, were also collected. Results: No significant differences were found in total foot hydration between the SSc and control groups (p = 0.254 for the right foot, p = 0.835 for the left foot), although a trend towards lower hydration was observed in the feet of affected patients. Differences were identified in specific areas of the foot, with lower hydration levels in the arch and the medial and lateral heel regions. In the medial arch of the right foot, the SSc group showed significantly lower hydration (p = 0.006). No significant associations were found with age, body mass index (BMI), physical activity, or water intake, but an association with smoking habits was observed in SSc patients; non-smokers had higher foot hydration levels compared to former and current smokers (p = 0.06). Conclusion: Patients with systemic sclerosis present reduced hydration in specific areas of the foot, particularly in the medial arch. Smoking may negatively influence foot skin hydration. Further research is needed to explore these findings and their implications for podiatric care in patients with SSc.ElsevierDepartamentos de la UMH::Ciencias del Comportamiento y salud202520252025info:eu-repo/semantics/articleapplication/pdf5application/pdfhttps://hdl.handle.net/11000/37559reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheIngléshttps://doi.org/10.1016/j.jtv.2025.100929info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/375592026-05-27T13:36:21Z
dc.title.none.fl_str_mv Impact of systemic sclerosis on foot skin hydration: A case-control study
title Impact of systemic sclerosis on foot skin hydration: A case-control study
spellingShingle Impact of systemic sclerosis on foot skin hydration: A case-control study
Gracia Sánchez, Alba
Systemic sclerosis
Skin hydration
Foot, corneometer
Stratum corneum hydration
Scleroderma
CDU::6 - Ciencias aplicadas::61 - Medicina
title_short Impact of systemic sclerosis on foot skin hydration: A case-control study
title_full Impact of systemic sclerosis on foot skin hydration: A case-control study
title_fullStr Impact of systemic sclerosis on foot skin hydration: A case-control study
title_full_unstemmed Impact of systemic sclerosis on foot skin hydration: A case-control study
title_sort Impact of systemic sclerosis on foot skin hydration: A case-control study
dc.creator.none.fl_str_mv Gracia Sánchez, Alba
García Cano, Laura
Ramos-Petersen, Laura
Gijon-Nogueron, Gabriel
Zúnica García, Sara
Chicharro-Luna, Esther
author Gracia Sánchez, Alba
author_facet Gracia Sánchez, Alba
García Cano, Laura
Ramos-Petersen, Laura
Gijon-Nogueron, Gabriel
Zúnica García, Sara
Chicharro-Luna, Esther
author_role author
author2 García Cano, Laura
Ramos-Petersen, Laura
Gijon-Nogueron, Gabriel
Zúnica García, Sara
Chicharro-Luna, Esther
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Ciencias del Comportamiento y salud
dc.subject.none.fl_str_mv Systemic sclerosis
Skin hydration
Foot, corneometer
Stratum corneum hydration
Scleroderma
CDU::6 - Ciencias aplicadas::61 - Medicina
topic Systemic sclerosis
Skin hydration
Foot, corneometer
Stratum corneum hydration
Scleroderma
CDU::6 - Ciencias aplicadas::61 - Medicina
description Introduction: Systemic sclerosis (SSc), or scleroderma, is a connective tissue disease characterized by excessive collagen production, leading to microvascular damage, fibrosis, and dysfunction of the skin and internal organs. The skin of the foot, due to its weight-bearing function and exposure to mechanical forces, may undergo alterations, contributing to the development of ulcers and other podiatric complications. However, little is known about foot skin hydration in patients with SSc. This study aims to assess the hydration level of the stratum corneum in the foot skin of patients with SSc. Materials and methods: A case-control study was conducted at the Clinical Rheumatology Unit of the Regional University Hospital of M´alaga (Spain). Participants included 47 patients diagnosed with SSc and 52 age- and sexmatched controls. Hydration measurements were performed at ten points on the foot using the Corneometer 825® device. Sociodemographic and clinical data, including smoking habits, were also collected. Results: No significant differences were found in total foot hydration between the SSc and control groups (p = 0.254 for the right foot, p = 0.835 for the left foot), although a trend towards lower hydration was observed in the feet of affected patients. Differences were identified in specific areas of the foot, with lower hydration levels in the arch and the medial and lateral heel regions. In the medial arch of the right foot, the SSc group showed significantly lower hydration (p = 0.006). No significant associations were found with age, body mass index (BMI), physical activity, or water intake, but an association with smoking habits was observed in SSc patients; non-smokers had higher foot hydration levels compared to former and current smokers (p = 0.06). Conclusion: Patients with systemic sclerosis present reduced hydration in specific areas of the foot, particularly in the medial arch. Smoking may negatively influence foot skin hydration. Further research is needed to explore these findings and their implications for podiatric care in patients with SSc.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/37559
url https://hdl.handle.net/11000/37559
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.jtv.2025.100929
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
5
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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