Distinct mutational pattern of myelodysplastic syndromes with and without 5q– treated with lenalidomide

Myelodysplastic syndromes (MDS) are a heterogeneousgroup of clonal stem cell disorders characterised by ineffec-tive haematopoiesis leading to peripheral blood cytopeniasand an increased risk of transformation to acute myeloid leu-kaemia (AML) (Haferlachet al., 2014; Makishimaet al.,2017). One of th...

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Detalles Bibliográficos
Autores: Adema, Vera, Palomo, Laura, Toma, Andrea, Kosmider, Olivier, Fuster Tormo, Francisco, Benito, Rocio, Salgado, Rocío, Such, Esperanza, Larráyoz, María José, Xicoy, Blanca, Hernández Sánchez, Jesús M., Maietta, Paolo, Fontenay, Michaela, Ibáñez, Mariam, Díez Campelo, María, Álvarez de Andrés, Sara, Maciejewski, Jaroslaw, Fenaux, Pierre, Solé, Francesc, Neef, Alexander
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/3899
Acceso en línea:http://hdl.handle.net/20.500.12466/3899
Access Level:acceso abierto
Palabra clave:Myelodysplastic syndromes
del(5q)
non‐del(5q)
Mutations
Lenalidomide
3205.04 Hematología
Descripción
Sumario:Myelodysplastic syndromes (MDS) are a heterogeneousgroup of clonal stem cell disorders characterised by ineffec-tive haematopoiesis leading to peripheral blood cytopeniasand an increased risk of transformation to acute myeloid leu-kaemia (AML) (Haferlachet al., 2014; Makishimaet al.,2017). One of the most common cytogenetic alterations isthe deletion of the long arm of chromosome 5q [del(5q)],which can be found isolated or with other alterations (10–30% of patients with MDS). Lenalidomide (LEN) has beenapproved for the treatment of patients with del(5q) low‐riskMDS and transfusion dependence. Almost 50% of patientswith del(5q) will show a complete cytogenetic remission and70% of them will reach transfusion independence (Listet al.,2006)...

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