Antiviral Activity of Self‐Assembled Glycodendro[60]fullerene Monoadducts

A series of amphiphilic glycodendro[60]fullerene monoadducts were efficiently synthesized using the CuAAC “click chemistry” approach. These glycodendrofullerenes can self‐assemble in aqueous media, in a process favoured through π‐ π interactions between the [60]fullerene moieties. This aggregation p...

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Detalles Bibliográficos
Autores: Muñoz, Antonio, Illescas Martínez, Beatriz María, Luczkowiak, Joanna, Lasala, Fátima, Ribeiro Viana, Renato, Rojo, Javier, Delgado Vázquez, Rafael, Martín León, Nazario
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/18415
Acceso en línea:https://hdl.handle.net/20.500.14352/18415
Access Level:acceso abierto
Palabra clave:547
Química orgánica (Química)
2306 Química Orgánica
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spelling Antiviral Activity of Self‐Assembled Glycodendro[60]fullerene MonoadductsMuñoz, AntonioIllescas Martínez, Beatriz MaríaLuczkowiak, JoannaLasala, FátimaRibeiro Viana, RenatoRojo, JavierDelgado Vázquez, RafaelMartín León, Nazario547Química orgánica (Química)2306 Química OrgánicaA series of amphiphilic glycodendro[60]fullerene monoadducts were efficiently synthesized using the CuAAC “click chemistry” approach. These glycodendrofullerenes can self‐assemble in aqueous media, in a process favoured through π‐ π interactions between the [60]fullerene moieties. This aggregation process leads to big and well‐defined compact micelles with a uniform size and spherical‐shape. The supramolecular aggregate was characterized using electronic microscopy (SEM and TEM), light scattering methods (DLS) and X‐ray methodologies (SAXS and XRD). The antiviral efficiency of these aggregates has been tested in an experimental infection assay using Ebola virus glycoprotein (EboGP) pseudotyped viral particles on Jurkat cells overexpressing DC‐SIGN and it is observed an improvement of the IC50 value with respect to other systems endowed with a higher number of carbohydrate ligands.RSCUniversidad Complutense de Madrid20172017-06-1220172017-06-12journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/18415reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/184152026-06-02T12:44:21Z
dc.title.none.fl_str_mv Antiviral Activity of Self‐Assembled Glycodendro[60]fullerene Monoadducts
title Antiviral Activity of Self‐Assembled Glycodendro[60]fullerene Monoadducts
spellingShingle Antiviral Activity of Self‐Assembled Glycodendro[60]fullerene Monoadducts
Muñoz, Antonio
547
Química orgánica (Química)
2306 Química Orgánica
title_short Antiviral Activity of Self‐Assembled Glycodendro[60]fullerene Monoadducts
title_full Antiviral Activity of Self‐Assembled Glycodendro[60]fullerene Monoadducts
title_fullStr Antiviral Activity of Self‐Assembled Glycodendro[60]fullerene Monoadducts
title_full_unstemmed Antiviral Activity of Self‐Assembled Glycodendro[60]fullerene Monoadducts
title_sort Antiviral Activity of Self‐Assembled Glycodendro[60]fullerene Monoadducts
dc.creator.none.fl_str_mv Muñoz, Antonio
Illescas Martínez, Beatriz María
Luczkowiak, Joanna
Lasala, Fátima
Ribeiro Viana, Renato
Rojo, Javier
Delgado Vázquez, Rafael
Martín León, Nazario
author Muñoz, Antonio
author_facet Muñoz, Antonio
Illescas Martínez, Beatriz María
Luczkowiak, Joanna
Lasala, Fátima
Ribeiro Viana, Renato
Rojo, Javier
Delgado Vázquez, Rafael
Martín León, Nazario
author_role author
author2 Illescas Martínez, Beatriz María
Luczkowiak, Joanna
Lasala, Fátima
Ribeiro Viana, Renato
Rojo, Javier
Delgado Vázquez, Rafael
Martín León, Nazario
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 547
Química orgánica (Química)
2306 Química Orgánica
topic 547
Química orgánica (Química)
2306 Química Orgánica
description A series of amphiphilic glycodendro[60]fullerene monoadducts were efficiently synthesized using the CuAAC “click chemistry” approach. These glycodendrofullerenes can self‐assemble in aqueous media, in a process favoured through π‐ π interactions between the [60]fullerene moieties. This aggregation process leads to big and well‐defined compact micelles with a uniform size and spherical‐shape. The supramolecular aggregate was characterized using electronic microscopy (SEM and TEM), light scattering methods (DLS) and X‐ray methodologies (SAXS and XRD). The antiviral efficiency of these aggregates has been tested in an experimental infection assay using Ebola virus glycoprotein (EboGP) pseudotyped viral particles on Jurkat cells overexpressing DC‐SIGN and it is observed an improvement of the IC50 value with respect to other systems endowed with a higher number of carbohydrate ligands.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-06-12
2017
2017-06-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/18415
url https://hdl.handle.net/20.500.14352/18415
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv RSC
publisher.none.fl_str_mv RSC
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409184759414784
score 15.198674

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