TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations

This is an open access article distributed under the Creative Commons Attribution License.

Bibliographic Details
Authors: Hernández-Sánchez, María, Rodríguez-Vicente, Ana Eugenia, Kohlmann, Alexander, Benito, Rocío, García, Juan L., Risueño, A., Fermiñán, Encarnación, De Las Rivas, Javier, González, Marcos, Hernández, Jesús M.
Format: article
Status:Published version
Publication Date:2014
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/134575
Online Access:http://hdl.handle.net/10261/134575
Access Level:Open access
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spelling TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variationsHernández-Sánchez, MaríaRodríguez-Vicente, Ana EugeniaKohlmann, AlexanderBenito, RocíoGarcía, Juan L.Risueño, A.Fermiñán, EncarnaciónDe Las Rivas, JavierGonzález, MarcosHernández, Jesús M.This is an open access article distributed under the Creative Commons Attribution License.TET2 is involved in a variety of hematopoietic malignancies, mainly in myeloid malignancies. Most mutations of TET2 have been identified in myeloid disorders, but some have also recently been described in mature lymphoid neoplasms. In contrast to the large amount of data about mutations of TET2, some data are available for gene expression. Moreover, the role of TET2 in chronic lymphocytic leukemia (CLL) is unknown. This study analyzes both TET2 expression and mutations in 48 CLL patients. TET2 expression was analyzed by exon arrays and quantitative real-time polymerase chain reaction (qRT-PCR). Next-generation sequencing (NGS) technology was applied to investigate the presence of TET2 variations. Overexpression of TET2 was observed in B-cell lymphocytes from CLL patients compared with healthy donors (P = 0.004). In addition, in CLL patients, an overexpression of TET2 was also observed in the clonal B cells compared with the nontumoral cells (P = 0.002). However, no novel mutations were observed. Therefore, overexpression of TET2 in CLL seems to be unrelated to the presence of genomic TET2 variations.This work was partially supported by Grants from the Spanish Fondo de Investigaciones Sanitarias FIS 09/01543, PI12/00281, Proyectos de Investigacion del SACYL 355/A/09, COST Action “EuGESMA” (BM0801), Fundación “Manuel Solorzano,” Obra Social Banca Cívica (Caja Burgos), Fundacion Española de Hematología y Hemoterapia (FEHH), and by a Grant (RD12/0036/0069) from Red Temática de Investigación Cooperativa en Cáncer (RTICC), Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness and European Regional Development Fund (ERDF) “Una manera de hacer Europa”, and NGS-PTL no. 306242. Maríıa Hernandez-Sánchez is fully suported by an “Ayuda predoctoral de la Junta de Castilla y Leon” by the “Fondo Social Europeo.”Peer ReviewedHindawi Publishing CorporationFundación Memoria de D. Samuel Solorzano BarrusoFundación Caja de BurgosRed Temática de Investigación Cooperativa en Cáncer (España)Instituto de Salud Carlos IIIInstituto de Salud Carlos IIIMinisterio de Economía y Competitividad (España)Sociedad Española de Hematología y HemoterapiaJunta de Castilla y LeónEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2016201620142016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/134575reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1155/2014/814294Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1345752026-05-22T06:33:51Z
dc.title.none.fl_str_mv TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations
title TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations
spellingShingle TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations
Hernández-Sánchez, María
title_short TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations
title_full TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations
title_fullStr TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations
title_full_unstemmed TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations
title_sort TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations
dc.creator.none.fl_str_mv Hernández-Sánchez, María
Rodríguez-Vicente, Ana Eugenia
Kohlmann, Alexander
Benito, Rocío
García, Juan L.
Risueño, A.
Fermiñán, Encarnación
De Las Rivas, Javier
González, Marcos
Hernández, Jesús M.
author Hernández-Sánchez, María
author_facet Hernández-Sánchez, María
Rodríguez-Vicente, Ana Eugenia
Kohlmann, Alexander
Benito, Rocío
García, Juan L.
Risueño, A.
Fermiñán, Encarnación
De Las Rivas, Javier
González, Marcos
Hernández, Jesús M.
author_role author
author2 Rodríguez-Vicente, Ana Eugenia
Kohlmann, Alexander
Benito, Rocío
García, Juan L.
Risueño, A.
Fermiñán, Encarnación
De Las Rivas, Javier
González, Marcos
Hernández, Jesús M.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundación Memoria de D. Samuel Solorzano Barruso
Fundación Caja de Burgos
Red Temática de Investigación Cooperativa en Cáncer (España)
Instituto de Salud Carlos III
Instituto de Salud Carlos III
Ministerio de Economía y Competitividad (España)
Sociedad Española de Hematología y Hemoterapia
Junta de Castilla y León
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description This is an open access article distributed under the Creative Commons Attribution License.
publishDate 2014
dc.date.none.fl_str_mv 2014
2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/134575
url http://hdl.handle.net/10261/134575
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1155/2014/814294
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.228081

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