Analysis of Whole Genome Resequencing Datasets from a Worldwide Sample of Sheep Breeds to Identify Potential Causal Mutations Influencing Milk Composition Traits

[EN] Different studies have shown that polymorphisms in the sequence of genes coding for the milk proteins and milk fatty acids are associated with milk composition traits as well as with cheese-making traits. However, the lack of coincident results across sheep populations has prevented the use of...

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Autores: Marina García, Héctor, Gutiérrez Gil, Beatriz, Esteban Blanco, Cristina, Suárez Vega, Aroa, Pelayo García, Rocío, Arranz Santos, Juan José
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Universidad de León
Repositorio:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/24294
Acesso em linha:https://www.mdpi.com/2076-2615/10/9/1542
https://hdl.handle.net/10612/24294
Access Level:acceso abierto
Palavra-chave:Producción animal
Veterinaria
Dairy sheep
Milk production
Genetic polymorphism
Ruminants
Whole genome sequence
3109 Ciencias Veterinarias
3104 Producción Animal
2401.08 Genética Animal
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spelling Analysis of Whole Genome Resequencing Datasets from a Worldwide Sample of Sheep Breeds to Identify Potential Causal Mutations Influencing Milk Composition TraitsMarina García, HéctorGutiérrez Gil, BeatrizEsteban Blanco, CristinaSuárez Vega, AroaPelayo García, RocíoArranz Santos, Juan JoséProducción animalVeterinariaDairy sheepMilk productionGenetic polymorphismRuminantsWhole genome sequence3109 Ciencias Veterinarias3104 Producción Animal2401.08 Genética Animal[EN] Different studies have shown that polymorphisms in the sequence of genes coding for the milk proteins and milk fatty acids are associated with milk composition traits as well as with cheese-making traits. However, the lack of coincident results across sheep populations has prevented the use of this information in sheep breeding programs. The main objective of this study was to exploit the information derived from a total of 175 whole genome resequencing (WGR) datasets from 43 domestic sheep breeds and three wild sheep to evaluate the genetic diversity of 24 candidate genes for milk composition and identify genetic variants with a potential phenotypic effect. The functional annotation of the identified variants highlighted five single nucleotide polymorphisms (SNPs) predicted to have a high impact on the protein function and 42 missense SNPs with a putative deleterious effect. When comparing the allelic frequencies at these 47 polymorphisms with relevant functional effects between the genomes of Assaf and Churra sheep breeds, two missense deleterious variants were identified as potential markers associated to the milk composition differences found between the Churra and Assaf: XDH:92215727C>T and LALBA:137390760T>C. Future research is required to confirm the effect of the potential functionally relevant variants identified in the present study on milk composition and cheese-making traitsSIThis research work was financially supported by the RTI2018-093535-B-I00 project of the Spanish Ministry of Science and Innovation (Madrid, Spain) co-funded by the European Regional Development Fund. H. Marina is funded by an FPU from Ministry of Science, Innovation and Universities (MICIU, Ref. FPU16/01161)MDPIProducción AnimalFacultad de Veterinaria2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://www.mdpi.com/2076-2615/10/9/1542https://hdl.handle.net/10612/24294reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad de LeónInglésinfo:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/RTI2018-093535-B-I00info:eu-repo/grantAgreement/MECD/ Programa Estatal de Promoción del Talento y su Empleabilidad/ FPU16http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/242942026-06-24T12:43:27Z
dc.title.none.fl_str_mv Analysis of Whole Genome Resequencing Datasets from a Worldwide Sample of Sheep Breeds to Identify Potential Causal Mutations Influencing Milk Composition Traits
title Analysis of Whole Genome Resequencing Datasets from a Worldwide Sample of Sheep Breeds to Identify Potential Causal Mutations Influencing Milk Composition Traits
spellingShingle Analysis of Whole Genome Resequencing Datasets from a Worldwide Sample of Sheep Breeds to Identify Potential Causal Mutations Influencing Milk Composition Traits
Marina García, Héctor
Producción animal
Veterinaria
Dairy sheep
Milk production
Genetic polymorphism
Ruminants
Whole genome sequence
3109 Ciencias Veterinarias
3104 Producción Animal
2401.08 Genética Animal
title_short Analysis of Whole Genome Resequencing Datasets from a Worldwide Sample of Sheep Breeds to Identify Potential Causal Mutations Influencing Milk Composition Traits
title_full Analysis of Whole Genome Resequencing Datasets from a Worldwide Sample of Sheep Breeds to Identify Potential Causal Mutations Influencing Milk Composition Traits
title_fullStr Analysis of Whole Genome Resequencing Datasets from a Worldwide Sample of Sheep Breeds to Identify Potential Causal Mutations Influencing Milk Composition Traits
title_full_unstemmed Analysis of Whole Genome Resequencing Datasets from a Worldwide Sample of Sheep Breeds to Identify Potential Causal Mutations Influencing Milk Composition Traits
title_sort Analysis of Whole Genome Resequencing Datasets from a Worldwide Sample of Sheep Breeds to Identify Potential Causal Mutations Influencing Milk Composition Traits
dc.creator.none.fl_str_mv Marina García, Héctor
Gutiérrez Gil, Beatriz
Esteban Blanco, Cristina
Suárez Vega, Aroa
Pelayo García, Rocío
Arranz Santos, Juan José
author Marina García, Héctor
author_facet Marina García, Héctor
Gutiérrez Gil, Beatriz
Esteban Blanco, Cristina
Suárez Vega, Aroa
Pelayo García, Rocío
Arranz Santos, Juan José
author_role author
author2 Gutiérrez Gil, Beatriz
Esteban Blanco, Cristina
Suárez Vega, Aroa
Pelayo García, Rocío
Arranz Santos, Juan José
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Producción Animal
Facultad de Veterinaria
dc.subject.none.fl_str_mv Producción animal
Veterinaria
Dairy sheep
Milk production
Genetic polymorphism
Ruminants
Whole genome sequence
3109 Ciencias Veterinarias
3104 Producción Animal
2401.08 Genética Animal
topic Producción animal
Veterinaria
Dairy sheep
Milk production
Genetic polymorphism
Ruminants
Whole genome sequence
3109 Ciencias Veterinarias
3104 Producción Animal
2401.08 Genética Animal
description [EN] Different studies have shown that polymorphisms in the sequence of genes coding for the milk proteins and milk fatty acids are associated with milk composition traits as well as with cheese-making traits. However, the lack of coincident results across sheep populations has prevented the use of this information in sheep breeding programs. The main objective of this study was to exploit the information derived from a total of 175 whole genome resequencing (WGR) datasets from 43 domestic sheep breeds and three wild sheep to evaluate the genetic diversity of 24 candidate genes for milk composition and identify genetic variants with a potential phenotypic effect. The functional annotation of the identified variants highlighted five single nucleotide polymorphisms (SNPs) predicted to have a high impact on the protein function and 42 missense SNPs with a putative deleterious effect. When comparing the allelic frequencies at these 47 polymorphisms with relevant functional effects between the genomes of Assaf and Churra sheep breeds, two missense deleterious variants were identified as potential markers associated to the milk composition differences found between the Churra and Assaf: XDH:92215727C>T and LALBA:137390760T>C. Future research is required to confirm the effect of the potential functionally relevant variants identified in the present study on milk composition and cheese-making traits
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.mdpi.com/2076-2615/10/9/1542
https://hdl.handle.net/10612/24294
url https://www.mdpi.com/2076-2615/10/9/1542
https://hdl.handle.net/10612/24294
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/RTI2018-093535-B-I00
info:eu-repo/grantAgreement/MECD/ Programa Estatal de Promoción del Talento y su Empleabilidad/ FPU16
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:BULERIA. Repositorio Institucional de la Universidad de León
instname:Universidad de León
instname_str Universidad de León
reponame_str BULERIA. Repositorio Institucional de la Universidad de León
collection BULERIA. Repositorio Institucional de la Universidad de León
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.223283

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