LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics

Psychedelics are serotonergic drugs that profoundly alter consciousness, yet their neural mechanisms are not fully understood. A popular theory, RElaxed Beliefs Under pSychedelics (REBUS), posits that psychedelics flatten the hierarchy of information flow in the brain. Here, we investigate hierarchy...

ver descrição completa

Detalhes bibliográficos
Autores: Shinozuka, Kenneth, Tewarie, Prejaas, Luppi, Andrea I., Lynn, Christopher, Roseman, Leor, Muthukumaraswamy, Suresh, Nutt, David J., Carhart-Harris, Robin L., Deco, Gustavo, Kringelbach, Morten L.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/72696
Acesso em linha:https://hdl.handle.net/10230/72696
http://dx.doi.org/10.1162/imag_a_00420
Access Level:acceso abierto
Palavra-chave:Psychedelics
LSD
Hierarchy
Entropy
MEG
Functional connectivity
id ES_5bcbcad38a326981e660b4a5df48fa6a
oai_identifier_str oai:repositori.upf.edu:10230/72696
network_acronym_str ES
network_name_str España
repository_id_str
spelling LSD flattens the hierarchy of directed information flow in fast whole-brain dynamicsShinozuka, KennethTewarie, PrejaasLuppi, Andrea I.Lynn, ChristopherRoseman, LeorMuthukumaraswamy, SureshNutt, David J.Carhart-Harris, Robin L.Deco, GustavoKringelbach, Morten L.PsychedelicsLSDHierarchyEntropyMEGFunctional connectivityPsychedelics are serotonergic drugs that profoundly alter consciousness, yet their neural mechanisms are not fully understood. A popular theory, RElaxed Beliefs Under pSychedelics (REBUS), posits that psychedelics flatten the hierarchy of information flow in the brain. Here, we investigate hierarchy based on the imbalance between sending and receiving brain signals, as determined by directed functional connectivity. We measure properties of directed functional hierarchy in a magnetoencephalography (MEG) dataset of 16 healthy human participants who were administered a psychedelic dose (75 micrograms, intravenous) of lysergic acid diethylamide (LSD) under four different conditions: eyes-closed with or without music and eyes-open with or without a video stimulus. Across the whole brain, LSD diminishes the asymmetry of directed connectivity when averaged across time. Additionally, we demonstrate that machine learning classifiers distinguish between LSD and placebo more accurately when trained on one of our hierarchy metrics than when trained on traditional measures of functional connectivity. Taken together, these results indicate that LSD weakens the hierarchy of directed connectivity in the brain by increasing the balance between senders and receivers of neural signals.MIT Press2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/72696http://dx.doi.org/10.1162/imag_a_00420reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésImaging Neuroscience. 2025;3:imag_a_00420© 2024 The Authors. Published under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For a full description of the license, please visit https://creativecommons.org/licenses/by/4.0/legalcode.https://creativecommons.org/licenses/by/4.0/legalcodeinfo:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/726962026-06-12T07:21:37Z
dc.title.none.fl_str_mv LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics
title LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics
spellingShingle LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics
Shinozuka, Kenneth
Psychedelics
LSD
Hierarchy
Entropy
MEG
Functional connectivity
title_short LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics
title_full LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics
title_fullStr LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics
title_full_unstemmed LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics
title_sort LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics
dc.creator.none.fl_str_mv Shinozuka, Kenneth
Tewarie, Prejaas
Luppi, Andrea I.
Lynn, Christopher
Roseman, Leor
Muthukumaraswamy, Suresh
Nutt, David J.
Carhart-Harris, Robin L.
Deco, Gustavo
Kringelbach, Morten L.
author Shinozuka, Kenneth
author_facet Shinozuka, Kenneth
Tewarie, Prejaas
Luppi, Andrea I.
Lynn, Christopher
Roseman, Leor
Muthukumaraswamy, Suresh
Nutt, David J.
Carhart-Harris, Robin L.
Deco, Gustavo
Kringelbach, Morten L.
author_role author
author2 Tewarie, Prejaas
Luppi, Andrea I.
Lynn, Christopher
Roseman, Leor
Muthukumaraswamy, Suresh
Nutt, David J.
Carhart-Harris, Robin L.
Deco, Gustavo
Kringelbach, Morten L.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Psychedelics
LSD
Hierarchy
Entropy
MEG
Functional connectivity
topic Psychedelics
LSD
Hierarchy
Entropy
MEG
Functional connectivity
description Psychedelics are serotonergic drugs that profoundly alter consciousness, yet their neural mechanisms are not fully understood. A popular theory, RElaxed Beliefs Under pSychedelics (REBUS), posits that psychedelics flatten the hierarchy of information flow in the brain. Here, we investigate hierarchy based on the imbalance between sending and receiving brain signals, as determined by directed functional connectivity. We measure properties of directed functional hierarchy in a magnetoencephalography (MEG) dataset of 16 healthy human participants who were administered a psychedelic dose (75 micrograms, intravenous) of lysergic acid diethylamide (LSD) under four different conditions: eyes-closed with or without music and eyes-open with or without a video stimulus. Across the whole brain, LSD diminishes the asymmetry of directed connectivity when averaged across time. Additionally, we demonstrate that machine learning classifiers distinguish between LSD and placebo more accurately when trained on one of our hierarchy metrics than when trained on traditional measures of functional connectivity. Taken together, these results indicate that LSD weakens the hierarchy of directed connectivity in the brain by increasing the balance between senders and receivers of neural signals.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10230/72696
http://dx.doi.org/10.1162/imag_a_00420
url https://hdl.handle.net/10230/72696
http://dx.doi.org/10.1162/imag_a_00420
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Imaging Neuroscience. 2025;3:imag_a_00420
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/legalcode
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/legalcode
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MIT Press
publisher.none.fl_str_mv MIT Press
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408839325974528
score 15,198674

Registos relacionados