Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout development

Understanding the neural mechanisms that regulate the stress response is critical to know how animals adapt to a changing world and is one of the key factors to be considered for improving animal welfare. Corticotropin-releasing factor (CRF) is crucial for regulating physiological and endocrine resp...

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Autores: Hanafi-Metwalli, Alek, Pross, Alessandra, Desfilis, Ester, Abellán Ródenas, Antonio, Medina Hernández, Loreta Mª
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/464044
Acceso en línea:https://doi.org/10.1002/cne.25517
https://hdl.handle.net/10459.1/464044
Access Level:acceso abierto
Palabra clave:Amygdala
Auditory pallium
Hippocampus
Hypothalamo–pituitary–adrenal axis
Stress
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spelling Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout developmentHanafi-Metwalli, Alek Pross, AlessandraDesfilis, EsterAbellán Ródenas, AntonioMedina Hernández, Loreta MªAmygdalaAuditory palliumHippocampusHypothalamo–pituitary–adrenal axisStressUnderstanding the neural mechanisms that regulate the stress response is critical to know how animals adapt to a changing world and is one of the key factors to be considered for improving animal welfare. Corticotropin-releasing factor (CRF) is crucial for regulating physiological and endocrine responses, triggering the activation of the sympathetic nervous system and the hypothalamo–pituitary–adrenal axis (HPA) during stress. In mammals, several telencephalic areas, such as the amygdala and the hippocampus, regulate the autonomic system and the HPA responses. These centers include subpopulations of CRF containing neurons that, by way of CRF receptors, play modulatory roles in the emotional and cognitive aspects of stress. CRF binding protein also plays a role, buffering extracellular CRF and regulating its availability. CRF role in activation of the HPA is evolutionary conserved in vertebrates, highlighting the relevance of this system to help animals cope with adversity. However, knowledge on CRF systems in the avian telencephalon is very limited, and no information exists on detailed expression of CRF receptors and binding protein. Knowing that the stress response changes with age, with important variations during the first week posthatching, the aim of this study was to analyze mRNA expression of CRF, CRF receptors 1 and 2, and CRF binding protein in chicken telencephalon throughout embryonic and early posthatching development, using in situ hybridization. Our results demonstrate an early expression of CRF and its receptors in pallial areas regulating sensory processing, sensorimotor integration and cognition, and a late expression in subpallial areas regulating the stress response. However, CRF buffering system develops earlier in the subpallium than in the pallium. These results help to understand the mechanisms underlying the negative effects of noise and light during prehatching stages in chicken, and suggest that stress regulation becomes more sophisticated with age.EuropeanCommission,Grant/AwardNumber:H2020-MSCA-ITN-2018-812777;AgenciaEstataldeInvestigación,Grant/AwardNumber:PID2019-108725RB-100Wiley2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1002/cne.25517https://hdl.handle.net/10459.1/464044reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)Inglésinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108725RB-I00Reproducció del document publicat a https://doi.org/10.1002/cne.25517Journal of Comparative Neurology, 2023, vol. 531, p. 1389-1424info:eu-repo/grantAgreement/EC/H2020/812777cc-by-nc-nd (c) Alek H. Metwalli et al., 2023Attribution-NonCommercial-NoDerivatives 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:repositori.udl.cat:10459.1/4640442026-06-24T12:42:17Z
dc.title.none.fl_str_mv Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout development
title Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout development
spellingShingle Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout development
Hanafi-Metwalli, Alek
Amygdala
Auditory pallium
Hippocampus
Hypothalamo–pituitary–adrenal axis
Stress
title_short Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout development
title_full Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout development
title_fullStr Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout development
title_full_unstemmed Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout development
title_sort Mapping of corticotropin-releasing factor, receptors, and binding protein mRNA in the chicken telencephalon throughout development
dc.creator.none.fl_str_mv Hanafi-Metwalli, Alek
Pross, Alessandra
Desfilis, Ester
Abellán Ródenas, Antonio
Medina Hernández, Loreta Mª
author Hanafi-Metwalli, Alek
author_facet Hanafi-Metwalli, Alek
Pross, Alessandra
Desfilis, Ester
Abellán Ródenas, Antonio
Medina Hernández, Loreta Mª
author_role author
author2 Pross, Alessandra
Desfilis, Ester
Abellán Ródenas, Antonio
Medina Hernández, Loreta Mª
author2_role author
author
author
author
dc.subject.none.fl_str_mv Amygdala
Auditory pallium
Hippocampus
Hypothalamo–pituitary–adrenal axis
Stress
topic Amygdala
Auditory pallium
Hippocampus
Hypothalamo–pituitary–adrenal axis
Stress
description Understanding the neural mechanisms that regulate the stress response is critical to know how animals adapt to a changing world and is one of the key factors to be considered for improving animal welfare. Corticotropin-releasing factor (CRF) is crucial for regulating physiological and endocrine responses, triggering the activation of the sympathetic nervous system and the hypothalamo–pituitary–adrenal axis (HPA) during stress. In mammals, several telencephalic areas, such as the amygdala and the hippocampus, regulate the autonomic system and the HPA responses. These centers include subpopulations of CRF containing neurons that, by way of CRF receptors, play modulatory roles in the emotional and cognitive aspects of stress. CRF binding protein also plays a role, buffering extracellular CRF and regulating its availability. CRF role in activation of the HPA is evolutionary conserved in vertebrates, highlighting the relevance of this system to help animals cope with adversity. However, knowledge on CRF systems in the avian telencephalon is very limited, and no information exists on detailed expression of CRF receptors and binding protein. Knowing that the stress response changes with age, with important variations during the first week posthatching, the aim of this study was to analyze mRNA expression of CRF, CRF receptors 1 and 2, and CRF binding protein in chicken telencephalon throughout embryonic and early posthatching development, using in situ hybridization. Our results demonstrate an early expression of CRF and its receptors in pallial areas regulating sensory processing, sensorimotor integration and cognition, and a late expression in subpallial areas regulating the stress response. However, CRF buffering system develops earlier in the subpallium than in the pallium. These results help to understand the mechanisms underlying the negative effects of noise and light during prehatching stages in chicken, and suggest that stress regulation becomes more sophisticated with age.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1002/cne.25517
https://hdl.handle.net/10459.1/464044
url https://doi.org/10.1002/cne.25517
https://hdl.handle.net/10459.1/464044
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108725RB-I00
Reproducció del document publicat a https://doi.org/10.1002/cne.25517
Journal of Comparative Neurology, 2023, vol. 531, p. 1389-1424
info:eu-repo/grantAgreement/EC/H2020/812777
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Alek H. Metwalli et al., 2023
Attribution-NonCommercial-NoDerivatives 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv cc-by-nc-nd (c) Alek H. Metwalli et al., 2023
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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