Inhibition of HIV-1 replication by RNA-based strategies

The major etiologic agent of the acquired immunodeficiency syndrome (AIDS) is the human immunodeficiency virus type 1 (HIV-1), which belongs to the family of human retroviruses. This pandemic infection affects millions of people worldwide. The most efficient current treatment regimen for HIV-infecte...

Full description

Bibliographic Details
Authors: Reyes-Darias, José Antonio, Sánchez-Luque, Francisco J., Berzal-Herranz, Alfredo
Format: article
Status:Versión enviada para evaluación y publicación
Publication Date:1988
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/143221
Online Access:http://hdl.handle.net/10261/143221
Access Level:Open access
Keyword:HIV-1
RNA therapies
ribozymes
Antisense RNAs
RNA aptamers
small interference RNAs
id ES_5ad9d1db2bfb5403dbb4916099e88d4b
oai_identifier_str oai:digital.csic.es:10261/143221
network_acronym_str ES
network_name_str España
repository_id_str
spelling Inhibition of HIV-1 replication by RNA-based strategiesReyes-Darias, José AntonioSánchez-Luque, Francisco J.Berzal-Herranz, AlfredoHIV-1RNA therapiesribozymesAntisense RNAsRNA aptamerssmall interference RNAsThe major etiologic agent of the acquired immunodeficiency syndrome (AIDS) is the human immunodeficiency virus type 1 (HIV-1), which belongs to the family of human retroviruses. This pandemic infection affects millions of people worldwide. The most efficient current treatment regimen for HIV-infected individuals combines two or more drugs targeting different HIV-specific enzymes. However, the emergence of multiple drug-resistant HIV-1 strains and the side effects of drug-based therapies make alternative approaches for the treatment of HIV infection and AIDS necessary. RNA-based antiviral approaches are among the most promising for developing long-term anti-HIV therapies. Anti-HIV-1 RNA-based strategies include ribozymes, antisense RNAs, RNA aptamers, RNA decoys, external guide sequences (EGS) for site-specific cleavage of RNA molecules with human ribonuclease P (RNase P), modified small nuclear RNA (RNAu) and small interfering RNAs (siRNAs). This review describes the main features and functions of viral and cellular targets as well as the different classes of RNA molecules that have been explored in developing therapeutic strategies against HIV infection. Many RNA-based strategies are already being tested in human clinical trials or are currently being developed for future trials.This work was supported by grants 34672/05 from FIPSE and BIO-265 from the Junta de Andalucía to AB-HPeer reviewedBentham Science PublishersConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201720171988info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Preprintinfo:eu-repo/semantics/submittedVersionhttp://hdl.handle.net/10261/143221reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://www.eurekaselect.com/92944/article#Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1432212026-05-22T06:33:51Z
dc.title.none.fl_str_mv Inhibition of HIV-1 replication by RNA-based strategies
title Inhibition of HIV-1 replication by RNA-based strategies
spellingShingle Inhibition of HIV-1 replication by RNA-based strategies
Reyes-Darias, José Antonio
HIV-1
RNA therapies
ribozymes
Antisense RNAs
RNA aptamers
small interference RNAs
title_short Inhibition of HIV-1 replication by RNA-based strategies
title_full Inhibition of HIV-1 replication by RNA-based strategies
title_fullStr Inhibition of HIV-1 replication by RNA-based strategies
title_full_unstemmed Inhibition of HIV-1 replication by RNA-based strategies
title_sort Inhibition of HIV-1 replication by RNA-based strategies
dc.creator.none.fl_str_mv Reyes-Darias, José Antonio
Sánchez-Luque, Francisco J.
Berzal-Herranz, Alfredo
author Reyes-Darias, José Antonio
author_facet Reyes-Darias, José Antonio
Sánchez-Luque, Francisco J.
Berzal-Herranz, Alfredo
author_role author
author2 Sánchez-Luque, Francisco J.
Berzal-Herranz, Alfredo
author2_role author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv HIV-1
RNA therapies
ribozymes
Antisense RNAs
RNA aptamers
small interference RNAs
topic HIV-1
RNA therapies
ribozymes
Antisense RNAs
RNA aptamers
small interference RNAs
description The major etiologic agent of the acquired immunodeficiency syndrome (AIDS) is the human immunodeficiency virus type 1 (HIV-1), which belongs to the family of human retroviruses. This pandemic infection affects millions of people worldwide. The most efficient current treatment regimen for HIV-infected individuals combines two or more drugs targeting different HIV-specific enzymes. However, the emergence of multiple drug-resistant HIV-1 strains and the side effects of drug-based therapies make alternative approaches for the treatment of HIV infection and AIDS necessary. RNA-based antiviral approaches are among the most promising for developing long-term anti-HIV therapies. Anti-HIV-1 RNA-based strategies include ribozymes, antisense RNAs, RNA aptamers, RNA decoys, external guide sequences (EGS) for site-specific cleavage of RNA molecules with human ribonuclease P (RNase P), modified small nuclear RNA (RNAu) and small interfering RNAs (siRNAs). This review describes the main features and functions of viral and cellular targets as well as the different classes of RNA molecules that have been explored in developing therapeutic strategies against HIV infection. Many RNA-based strategies are already being tested in human clinical trials or are currently being developed for future trials.
publishDate 1988
dc.date.none.fl_str_mv 1988
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Preprint
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/143221
url http://hdl.handle.net/10261/143221
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://www.eurekaselect.com/92944/article#
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408750244200448
score 15.812455

Similar Items